phenotypic – Page 17 – Communicable Diseases Research

Functional diversification accompanies gene family expansion of MED2 homologs in Candida albicans

기능적 다양화는 칸디다 알비칸스에서 MED2 상동체의 유전자 패밀리 확장을 수반합니다

Research Article

Published on 2018-04-092022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Genome-wide detection of conservative site-specific recombination in bacteria

박테리아에서 보존적 부위 특이적 재조합의 게놈 전체 검출

Research Article

Published on 2018-04-052022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] addition adopted Altering Analysis appear applicability applied approach archaeal Bacteria Bacterial bacterial specy characterization classical Clostridium difficile components condition conserved contributing to dataset dependent on described detect DNA ecological niche ecological niches Effectiveness Epidemic expand expressed Features fluctuations fluorescent Frequency Gene Expression generate genomes genomic Genomic DNA growth heterogeneity identify in some in vitro inversion lack lineages mechanism nucleotide occur opens pathogen pathogenic bacteria phenotypic platform Population population level Prevalence proliferation provide Rapid Recombination referred to responsible robust Sequencing single-nucleotide stationary strain subpopulation survival thought undergo Variation
[DOI] 10.1371/journal.pgen.1007332 PMC 바로가기 [Article Type] Research Article

Next generation sequencing of HIV-1 protease in the PIVOT trial of protease inhibitor monotherapy

프로테아제 억제제 단독 요법의 PIVOT 시험에서 HIV-1 프로테아제의 차세대 시퀀싱

Article

Published on 2018-04-012022-09-06
Journal: Journal of Clinical Virology [Category] Communicable Disease,

[키워드] Algorithm Antiretroviral therapy clinically Combination combination therapy Coverage described drug drug susceptibility Evidence examined frequencies Frequency frozen plasma Highlights HIV HIV-1 Laboratory leads Local low frequency median time Median viral load methodology monotherapy Mutation mutations next generation sequencing NGS objective Patient patients performed phenotypic plasma sample predict predicted Primary outcome protease Protease inhibitor Public Health England randomisation randomised reported resistance Result Ritonavir Sanger sequencing selected Sequencing Stanford Study design study drug suppressed susceptibility tested the median threshold Trial variant Viral Viral load was performed
[DOI] 10.1016/j.jcv.2018.02.003 PMC 바로가기 [Article Type] Article

Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania

심각한 말라리아 및 탄자니아 북동부의 선택적 압력과 관련된 새로운 유전적 다형성

Research Article

Published on 2018-01-302022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 말라리아,

[키워드] acquisition African allele frequencies allele frequency analyses approach association caused Cell characterisation chromosome chromosome 4 Cohort country dataset Endemic Evidence evidence of expected extended haplotype Factors Frequency GCLC gene mutation gene target Genetic genetic factors genetic mutation genetic mutations Genetic polymorphism Genome Genome-wide association studies Genome-wide association study genomes genotyping GWAS haplotypes HbS High-resolution histocompatibility Host Human genome human population human populations identification identify immunological pathways imputation independent Intervention joint KLHL3 linkage loci Major major histocompatibility complex malaria malarial disease mechanism MHC molecular morbidity Mortality natural selection novel parasites performed Phenotypes phenotypic phenotypic variation Plasmodium falciparum Plasmodium falciparum infection polymorphism Population Positive selection Protective Protein Rare variants receptor reduced risk Region Research resulting risk factor selection pressure selective Sequencing severe malaria sickle cell sickle cell trait Significant significant effect SNPs Structural variant structural variants sub-Saharan Africa susceptibility susceptibility loci SYNJ2BP target variant Variation whole genome Whole genome sequencing
[DOI] 10.1371/journal.pgen.1007172 PMC 바로가기 [Article Type] Research Article

Wor1 establishes opaque cell fate through inhibition of the general co-repressor Tup1 in Candida albicans

Wor1은 Candida albicans에서 일반적인 공동 억제 인자 Tup1의 억제를 통해 불투명한 세포 운명을 설정합니다.

Research Article

Published on 2018-01-162022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence Affect Affinity purification analyses Analysis approach Author bypass Candida Candida albican Candida albicans carbon carbon source carbon sources Cell cell fate cells colonization colonize commensal complex protein explain expressed facilitate Factor function functions fungal Genetic gut microbiota Host identify individuals induce Loss maintain mass spectrometry mass spectroscopy master regulator mechanism molecular Morphological occur pathogen pathogenic phenotypic plasticity positive feedback promoter Proteins provide Region regulated Regulation regulatory circuit repression repressor serious infection serious infections stability starting switching temperature transcriptional transcriptional repressor undergo white Wor1
[DOI] 10.1371/journal.pgen.1007176 PMC 바로가기 [Article Type] Research Article

The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases

인간 질병에 대한 단백질 바이오마커에 대한 DNA 메틸화 및 유전적 변이의 상대적 기여도

Research Article

Published on 2017-09-152022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] adjusted Affect allele alteration analyses analyzed association Biomarker Biomarkers Cancer cardiovascular disease cardiovascular diseases caused copy CXCL11 CXCL9 disease disease pathogenesis disease status disease-associated Diseases DNA methylation DNA methylation level DNA methylation levels driven by Effect effect size effect sizes effective environmental factor environmental factors Epigenetic Evidence expression expression patterns Factor Genes Genetic Genetic variant genetic variants Genetic variation Genome Genome-wide association study genomic position GWAS Human human disease human diseases IL-12 IL-18 Inflammation loci locus Modification MOST NLRC5 overlapped Pathogenesis performed phenotypic Protein risk smoking SNP SNPs trans unique Variation were measured while
[DOI] 10.1371/journal.pgen.1007005 PMC 바로가기 [Article Type] Research Article

A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides

비정규 RNA 분해 경로는 인간 곰팡이 병원체 Mucor circinelloides에서 RNAi 의존성 후성 돌연변이를 억제합니다

Research Article

Published on 2017-03-242022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activate Activation animal hosts Antifungal treatment Community component Compound conditions Degradation described determined by Dicer drug target drug-resistant effective Efficacy emerging disease ENhance environmental condition environmental conditions expression FK506 fungal Fungal infection fungal pathogen fungal pathogens fungi generate genetic analysis growth Helicase Host host-pathogen interaction host-pathogen interactions Human include inhibitory inhibitory effect involved isolate isolates lack mechanism molecular mechanism mRNA degradation Mucor Mucorale Mucorales Mucormycosis Mutation non-canonical RNA pathogen Pathogens pathway performed phenotype phenotypic plasticity prevented previous study Prognosis Protein provided RdRP recent Regulation represse Research RNAi RNAi pathway strain Strains stress conditions suppresse Target genes underlie
[DOI] 10.1371/journal.pgen.1006686 PMC 바로가기 [Article Type] Research Article

Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS

Retrotransposon 활성화는 ALS의 Drosophila TDP-43 모델에서 신경 퇴행에 기여합니다

Research Article

Published on 2017-03-162022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] abnormality accompanied Activation aggregation ALS Amyotrophic lateral sclerosis Author cascade cause cell death cell types cells Characteristics contribute cytoplasmic de-repression death degeneration degenerative disease DNA DNA binding protein DNA damage Drosophila Effect Effects element event Evidence expressed expression Familial Genetic Genome Glia glial cells hallmark human disease impair impairment Inclusion incurable inhibiting Lateral Sclerosis lobar locomotor LTR majority mechanism Mutation neurodegeneration neurodegenerative disorder neurodegenerative disorders Neuron neuronal neurons nuclear protein pathology pathophysiological phenotype phenotypic Premature programmed cell death PROTECT Protein repression retrotransposon retrotransposons retrovirus reverse transcriptase RNA RNA silencing siRNA Small interfering RNA storm subset the disease tissue Toxicity transcriptase
[DOI] 10.1371/journal.pgen.1006635 PMC 바로가기 [Article Type] Research Article

Allelic Variation in CXCL16 Determines CD3 + T Lymphocyte Susceptibility to Equine Arteritis Virus Infection and Establishment of Long-Term Carrier State in the Stallion

CXCL16의 대립형질 변이는 말 동맥염 바이러스 감염에 대한 CD3 + T 림프구 감수성과 종마의 장기 보균자 상태 확립을 결정합니다

Research Article

Published on 2016-12-082022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] acute infection allele allelic variant Amino acid amino acid change arteritis association carrier carrier state carriers causative agent CD3 cellular receptor cellular receptors chromosome 11 correlated correlated strongly CXCL16 demonstrated determine disease dominant equine ExoN exon 1 exposure to Genetic Genome Genome wide association study GWAS higher risk Ile Illumina implicated in vitro In vitro infection infect Infection inheritance Laboratory lack less life lymphocyte Lymphocytes maintenance male MOST Mutation natural infection Non-synonymous nucleotide nucleotide substitution nucleotide substitutions orthologue outcome persistence phenotype Phenotypes phenotypic phenotypic trait Previous studies previous study Probability proportion Protein protein isoform Proteins receptor reported reproductive required respiratory responsible risk scavenger receptor Semen shown significantly higher significantly lower Stallion susceptibility susceptible T lymphocyte T lymphocytes Two alleles Viral viral persistence virus virus carriers were used
[DOI] 10.1371/journal.pgen.1006467 PMC 바로가기 [Article Type] Research Article

Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp .

TLO 중재자 소단위 유전자의 증폭은 칸디다 종에서 필라멘트 성장을 촉진합니다.

Research Article

Published on 2016-10-142022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Activation amplification amplitude ascomycete ascomycetes binding domain bloodstream infection Bloodstream infections Candida Candida albican Candida albicans candidiasis cause cell physiology complex death DNA domain Engineering ENhance environmental cues eukaryotic exhibit facilitated Filamentous fungal fungi gene family Genome genomes genomic growth hallmark individual Infection infections Interaction less mediator mortality rate multitude murine mutant Nuclear localization nuclear localization signal nucleus ortholog overexpressed overexpression pathogenicity phenotype Phenotypes phenotypic plasticity Protein provide reduced regulate subunit Support systemic Candidiasis systemic infection target targets The United States Transcription transcription factor transcription factors transcriptional transcriptional activation unique United States virulence
[DOI] 10.1371/journal.pgen.1006373 PMC 바로가기 [Article Type] Research Article