Characteristics, clinical and laboratory data and outcomes of pregnant women with confirmed SARS-CoV-2 infection admitted to Al-Zahra tertiary referral maternity center in Iran: a case series of 24 patients이란 Al-Zahra 3차 의뢰 산부인과 센터에 입원한 SARS-CoV-2 감염 확인된 임산부의 특성, 임상 및 실험실 데이터 및 결과: 24명의 환자에 대한 일련의 사례Case Report Published on 2021-05-172022-09-01 Journal: BMC Pregnancy and Childbirth [Category] 진단, [키워드] abortion age Anosmia approved Asymptomatic case Asymptomatic cases Blood Group Blood pH Caesarean section Case series case sery change clinical clinical record clinical records clinical symptom Clinical symptoms complications cough COVID-19 COVID-19 complications diagnosis of COVID-19 diarrhea during pregnancy Dyspnea ethics committee evaluate Evidence evidence of Fever finding form gestational age greater healthy HELLP syndrome higher risk hospital Hospitalized hypertension immaturity indication Infection Iran Laboratory laboratory characteristics laboratory data lymphopenia maternity hospital morbidity and mortality myalgia Neonatal Neonate Newborn NICU NICU admission no evidence of no increase normal range nulliparous Obstetric outcome oxygen oxygen saturation Patient Pharyngeal swab Placenta pregnancies Pregnancy pregnancy complications pregnancy-induced hypertension pregnant patient pregnant patients pregnant women Premature premature labor Prevalence referred to Result risk SARS-COV-2 infection SpO2 Symptom Tabriz term tested Transmission university vertical vertical transmission was performed women [DOI] 10.1186/s12884-021-03764-y PMC 바로가기 [Article Type] Case Report
SARS-CoV-2 colonization of maternal and fetal cells of the human placenta promotes alteration of local renin-angiotensin systemArticle Published on 2021-05-142022-10-06 Journal: Med (New York, N.Y.) [Category] SARS, 진단, [키워드] ACE2 acute respiratory syndrome Alter angiotensin-converting enzyme 2 appear AT1-AA AT1R autoantibody backbone bind blood pressure Cell cells cellular colonize concomitant increase Control coronavirus decidua elevated expressing extravillous trophoblasts Factors fetal growth factor Hematoxylin and eosin hemodynamic highest immunohistochemistry Infection investigated Local marker occur outcomes pathophysiology Placenta placental PlGF positive pre-eclampsia Pregnancy pregnant women promote RAS receptor Recombinant spike protein reduced regulate renin-angiotensin system risk RNA SARS-CoV-2 SARS-COV-2 infection sFlt1. significantly Spike protein staining stomatitis tested treated tyrosine viral infection Viral RNA virus [DOI] 10.1016/j.medj.2021.04.009 PMC 바로가기 [Article Type] Article
Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface임신 중 산모 호흡기 SARS-CoV-2 감염은 산모-태아 경계면에서 강력한 염증 반응과 관련이 있습니다Article Published on 2021-05-142022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] absence ACE2 ACE2 expression Activation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed Cell cells center Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detectable early pregnancy exhibited full term Genes had no healthy histology Hofbauer cells immortalized cell line immortalized cell lines immune immune activation immune mechanism immune responses immunohistochemistry in vitro in vivo increased expression increased risk Infection Inflammatory response Local majority marker Maternal morbidity natural killer NIH outcome pathophysiology performed Placenta placental Placentas precursor precursors preeclampsia Pregnancy pregnancy complications pregnant women PROTECT respiratory robust SARS-CoV-2 SARS-COV-2 infection shielding single-cell stem cell stem cells Support T cells transcriptomics Viral viral infection viral invasion Viral RNA women [DOI] 10.1016/j.medj.2021.04.016 PMC 바로가기 [Article Type] Article
Placenta histopathology in SARS-CoV-2 infection: analysis of a consecutive series and comparison with control cohortsOriginal Article Published on 2021-05-012022-10-29 Journal: Virchows Archiv [Category] COVID-19, MERS, SARS, [키워드] accelerated alteration Analysis change chronic clinical conditions Cohort confounder COVID-19 diagnosed etiology expected Frequency Gynecology histopathological Histopathology Infarction Inflammation investigated maturation Microvascular thrombosis obstetrics organ pathological finding Placenta Placentas Pregnancy remained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis shown statistically significant subset thrombosis tissues with COVID-19 women [DOI] 10.1007/s00428-021-03097-3 PMC 바로가기 [Article Type] Original Article
Pathological findings in organs and tissues of patients with COVID-19: A systematic reviewResearch Article Published on 2021-04-282022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] addition Autopsy bronchopneumonia Case report case sery caused Cell chain change CNS Coagulopathy COVID-19 COVID-19 case COVID-19 infection DAD database death demonstrated described Diffuse alveolar damage disease edema Endothelial cell GI Tract hemodynamic Hepatitis immunofluorescence immunohistochemistry inclusion criteria intestine kidney liver lung medRxiv Microscopy myocarditis Necrosis nervous organ organ damage organ-specific organs pandemic pathologic pathological Patient PCR performed Placenta positive reaction reported resulting SARS-CoV-2 SARS-CoV-2 viral particle screened skin biopsy System systematic review tissue was performed [DOI] 10.1371/journal.pone.0250708 PMC 바로가기 [Article Type] Research Article
Maternal natural killer cells at the intersection between reproduction and mucosal immunityReview Article Published on 2021-04-262022-10-31 Journal: Mucosal Immunology [Category] COVID-19, MERS, [키워드] Cell Contact COVID-19 fetal fetoplacental functions growth help homeostatic Immune cell immune cells Immunity Infection Influenza Intersection Local Macrophage malaria Maternal maternal tissue microenvironment mucosal natural killer natural killer cell NK cell NK-cell pathogen Placenta Pregnancy respond response systemically toxoplasmosis uterine vasculature [DOI] 10.1038/s41385-020-00374-3 PMC 바로가기 [Article Type] Review Article
Vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A scoping reviewResearch Article Published on 2021-04-222022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] addressed amniotic Blood blood sample Breast feeding breast milk chest imaging CINAHL Community conducted coronavirus 2 country COVID-19 COVID-19 infection Effect elevated eligibility Evidence FIVE for inclusion hospital IgG and IgM inclusion criteria medRxiv mother Neonate Newborn newborn baby PCR Placenta Pneumonia positive Pregnancy pregnant women Research respiratory Result RT-PCR Sample size SARS-CoV-2 screened square Support tested throat swab tissue transfer Transmission transmission of SARS-CoV-2 vertical transmission Web of Science [DOI] 10.1371/journal.pone.0250196 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 and Placenta: New Insights and PerspectivesArticle Published on 2021-04-212022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] alteration arteriopathy conducted Control COVID COVID-19 disease fetal highlight histological histopathological Inflammation insight mechanism Microscopy New not significantly different outcomes pandemic Pathogenesis Placenta positive pregnancies Pregnancy pregnant women Prevalence SARS-CoV-2 significant difference Transmission two groups Vascular vessel virus viruses women [DOI] 10.3390/v13050723 PMC 바로가기 [Article Type] Article
Molecular Pathology Analysis of SARS-CoV-2 in Syncytiotrophoblast and Hofbauer Cells in Placenta from a Pregnant Woman and Fetus with COVID-19Article Published on 2021-04-152022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] abnormality ACE2 antibody CD163 Cell cells coronavirus Coronavirus disease 2019 COVID-19 determine double staining evaluate Evidence fetal infection fetus heterogeneous group Hofbauer cell Human immunodeficiency virus immunologically include infected with SARS-CoV-2 Infection intervillositis involved Macrophage macrophage marker maternal-fetal transmission membrane Molecular pathology Necrosis Neonate pathology Placenta placental Placental infection positive Protein RNA SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 nucleocapsid severe acute respiratory syndrome coronavirus 2 staining syncytiotrophoblast these cell TMPRSS2 Transmission transplacental transmission villous macrophages virus viruses with COVID-19 woman women Zika virus zone [DOI] 10.3390/pathogens10040479 PMC 바로가기 [Article Type] Article
Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin용어 인간 태반 영양막은 SARS-CoV-2 진입 인자 ACE2, TMPRSS2 및 푸린을 발현합니다Research Article Published on 2021-04-142022-09-10 Journal: mSphere [Category] MERS, SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affected angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Blood bloodstream caused cell type cell types cells Combination coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Defense demonstrated entry of SARS-CoV-2 enzyme Express expresse expressed expression expression of SARS-CoV-2 Factor Factors furin highest Human immunofluorescence In situ hybridization Infection Intervention Lungs maternal blood organ pandemic Particles Placenta placental Placental infection pregnant women protease pseudovirus quantitative PCR respiratory risk risk of COVID-19 RNA-Seq RT-qPCR SARS-CoV-2 SARS-CoV-2 entry factor SARS-CoV-2 entry factors SARS-COV-2 infection SARS-CoV-2 pseudovirus Serine serine 2 severe acute respiratory syndrome Coronavirus spread to term tested TMPRSS2 Transcriptome transcriptome sequencing transmembrane transmembrane protease serine 2 Transmission trophoblast Viremia virus while women [DOI] 10.1128/mSphere.00250-21 PMC 바로가기 [Article Type] Research Article