Impact of pre-existing immunity on the induction of functional cross-reactive anti-hemagglutinin stalk antibodies following vaccination with an AS03 adjuvanted pandemic H1N1 vaccineArticle Published on 2018-04-122023-06-24 Journal: Vaccine [Category] 신종인플루엔자, [키워드] cross-reactive Immunity Influenza pandemic vaccination priming Stalk antibodies. [DOI] 10.1016/j.vaccine.2018.02.022
Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production용해성 편모단백질 공동 면역화는 수지상세포 활성화 및 사이토카인 생산 조절을 통해 살모넬라에 대한 Th1 프라이밍과 제거를 약화시킨다.Article Published on 2015-08-242024-08-19 Journal: European Journal of Immunology [Category] 살모넬라증, [키워드] Dendritic cell activation flagellin priming Salmonella Typhimurium Th1 cells [DOI] 10.1002/eji.201545564 PMC 바로가기
Coronavirus virulence genes with main focus on SARS-CoV envelope geneArticle Published on 2014-08-022022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] activated activated T cell activating Activation acute respiratory distress Adaptive immune response addressed Affect animal model antagonist Apoptosis ARDS attenuate B cell binding cause cellular cellular pathway coronavirus CoV CoV genome CoV infection CoV protein cytokine death deleted deletion mutant described disease disease severity domain driver E protein edema elicit elicited envelope gene envelope protein exacerbated Host Host immune response humans IFN immune response immunopathological induce Infection inflammasome activation Inflammation Inflammatory response influence inhibiting innate immune responses innate immune system Innate immunity Interaction interferon interferon regulatory factor involved lung parenchyma manuscript MERS-CoV MHV mice Modification motif NF-κB NF-κB pathway nuclear Pathogenesis pathogenic pathogenicity pathway patients priming proinflammatory Proinflammatory cytokine promote proportion Protein Regulation Replication responses responsible SARS-CoV SARS-CoV E sequence shown Signaling signaling pathway Stress subgenomic mRNA synthesis syndrome TGEV transcription factor transmembrane transmembrane domain triggered vaccine candidates viral infections Viral protein virulence virulence gene virus virus infection [DOI] 10.1016/j.virusres.2014.07.024 PMC 바로가기 [Article Type] Article
Dendritic Cell-Specific Delivery of Flt3L by Coronavirus Vectors Secures Induction of Therapeutic Antitumor ImmunityResearch Article Published on 2013-11-282022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Antigen CD8 Combination compared coronavirus cytokine DC DCs delivery dendritic cell Efficacy epitope exhibited Express Host IL-15 IL-2 Immunity in vivo induce induction Ligand lymphocyte maturation microenvironment priming Prophylactic PROTECT provided T cell T cells therapeutic transduced Tumor tumor immunity tyrosine vaccination vector [DOI] 10.1371/journal.pone.0081442 PMC 바로가기 [Article Type] Research Article
Interferon Regulatory Factor 8 Regulates Pathways for Antigen Presentation in Myeloid Cells and during Tuberculosis인터페론 조절 인자 8은 골수 세포 및 결핵 기간 동안 항원 제시 경로를 조절합니다Research Article Published on 2011-06-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (major histocompatibility complex activate Activation allele Analysis Antigen presentation antigen processing Author binding binding site cellular pathway cellular pathways chromatin chromatin immunoprecipitation class Combination component Critical cytokine Defense dendritic cell dendritic cells differentiation early response endomembrane eQTLs expressed expression F2 Factor fixed functional Gene gene transcription GTPase GTPases histocompatibility complex Host–pathogen interaction identify IFNγ IL-12 IL12 immune response Infected Infection interferon gamma interferon regulatory factor interleukin intracellular pathogens intrinsic investigated IRF8 lipopolysaccharide LPS lung tissue lung tissues Lungs Macrophage macrophages major histocompatibility complex maturation member MHC mice Microarray Microarrays microbial motif mutant Mycobacterium tuberculosis myeloid myeloid cell myeloid cells ontogeny Pathogens pathway Pathways presentation priming progenitor cells promoter promoters Proteins pulmonary tuberculosis regulated Regulation represse required resistance to infection resistance to infections significantly Stimulation susceptible target transcript Transcription transcriptional treated Tuberculosis wild-type [DOI] 10.1371/journal.pgen.1002097 PMC 바로가기 [Article Type] Research Article