Complexities in Case Definition of SARS-CoV-2 Reinfection: Clinical Evidence and Implications in COVID-19 Surveillance and DiagnosisReview Published on 2021-09-292022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] addition clade clinical Clinical diagnosis clinical implication clinical symptom complexity Control country COVID-19 COVID-19 transmission Definition disease Evidence Infection Mild Mutation new SARS-CoV-2 offer Phylogenetic analysis prevention protective immunity Re-infection Reinfection reported SARS-CoV-2 sequence specimen Surveillance Transmissibility variant virus genome while [DOI] 10.3390/pathogens10101262 PMC 바로가기 [Article Type] Review
Fast and long-lasting immune response to S-trimer COVID-19 vaccine adjuvanted by PIKAResearch Published on 2021-09-272022-10-30 Journal: Molecular Biomedicine [Category] COVID-19, [키워드] addition B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 cellular COVID-19 COVID-19 vaccine develop effective humoral immune responses immune response induce long-lasting lung neutralize neutralizing antibody Neutralizing antibody response non-human primates P.1 PIKA protective immunity Protein robust S-trimer SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralization SARS-CoV-2 S protein SARS-CoV-2 variant supplementary material Support the vaccine trimeric utility Vaccine vaccine candidate variants variants of interest variants of SARS-CoV-2 virus replication [DOI] 10.1186/s43556-021-00054-z PMC 바로가기 [Article Type] Research
SARS-COV-2 recombinant Receptor-Binding-Domain (RBD) induces neutralizing antibodies against variant strains of SARS-CoV-2 and SARS-CoV-1SARS-COV-2 재조합 수용체 결합 도메인(RBD)은 SARS-CoV-2 및 SARS-CoV-1의 변이주에 대한 중화 항체를 유도합니다Article Published on 2021-09-242022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 진단, [키워드] activate adjuvants alum antibody approved B.1.1.7 B.1.351 booster cellular immune responses COVID19 cross-neutralization etiological agent evade Evidence Formulation immune responses in vitro induce less MPLA neutralization Neutralizing antibodies neutralizing antibody protective immunity RBD SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 Spike RBD Spike protein Spread strain tested the spike protein Vaccine vaccine antigen variant variants virion VoC [DOI] 10.1016/j.vaccine.2021.08.081 PMC 바로가기 [Article Type] Article
Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamstersVaccinia 바이러스 기반 백신은 시리아 햄스터에서 SARS-COV-2 바이러스에 대한 보호 면역을 부여합니다.Research Article Published on 2021-09-092022-09-10 Journal: PLoS ONE [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adenovirus-based Beta C57BL/6 candidate Candidates cause caused cold chain Coronavirus-2 Coronaviruses COVID-19 disease effective Express full-length SARS-CoV-2 full-length SARS-CoV-2 spike protein hamster hamsters Human immune response immune responses induce infected individual infected individuals Infection mammalian cells mice Mortality MOST mRNA Neutralizing antibodies neutralizing antibody Prevent protective immunity recombinant vaccine recombinant vaccines regimen regimens respiratory Respiratory illness SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe respiratory illness Spike protein vaccination Vaccine vaccine platform vaccinia vaccinia virus variant Viral viral spread viral strain viral strains virus [DOI] 10.1371/journal.pone.0257191 PMC 바로가기 [Article Type] Research Article
The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice자가 조립 나노 입자 기반 삼량체 RBD mRNA 백신은 마우스에서 SARS-CoV-2에 대한 강력하고 내구성 있는 보호 면역을 유도합니다Article Published on 2021-09-092022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, [키워드] addition Alpha B.1.1.7 B.1.351 Beta cellular response COVID-19 domain effective vaccine elicit elicited ferritin fused hACE2 Humoral immunity immunization Infectious diseases intramuscularly live SARS-CoV-2 low-dose mice mRNA mRNA vaccine mRNA vaccines multivalent vaccine neutralizing antibody produced protective immunity Protein provide provided RBD regimen robust Safe SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 spike Spread the RBD the SARS-CoV-2 trimer trimeric trimeric RBD Vaccine Vaccines variant variants [DOI] 10.1038/s41392-021-00750-w PMC 바로가기 [Article Type] Article
Degenerate CD8 Epitopes Mapping to Structurally Constrained Regions of the Spike Protein: A T Cell-Based Way-Out From the SARS-CoV-2 Variants Storm스파이크 단백질의 구조적으로 제한된 영역에 매핑되는 CD8 에피토프 변성: SARS-CoV-2 변이체 폭풍으로부터의 T 세포 기반 탈출구Review Published on 2021-09-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] Analysis analyzed arising B cell responses can not candidate CD8 CD8 T cell CD8 T cell epitopes CD8 T cell responses CD8 T cells CD8 T-cell Cell-mediated immunity compensated conserved COVID-19 vaccines cross-neutralization degenerate Efficacy ENhance epitope Epitopes Evolution expected HLA HLA class I HLA class I molecules immune response immune responses immunization immunodominant impairing inactivation limit maintain mapping mutate mutations Neutralizing antibodies Perspective Population Protective protective immunity Region response S-protein SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variants spike region stimulatory storm T cell T cell epitopes T cells the SARS-CoV-2 the Spike translational vaccination Vaccination strategies Vaccination strategy Vaccine Vaccines variant variants variants of concern Viral viral escape viral variant Viral variants [DOI] 10.3389/fimmu.2021.730051 PMC 바로가기 [Article Type] Review
Synthetic SARS-CoV-2 Spike-Based DNA Vaccine Elicits Robust and Long-Lasting Th1 Humoral and Cellular Immunity in MiceMicrobiology Published on 2021-09-072022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] BALB/c BALB/c mice binding candidate vaccine CD4 CD8 Cell cellular immunity clinical testing coding sequence Consensus coronavirus disease COVID-19 cytokine production demonstrated DNA DNA vaccine dose effective elicit elicited ENhance full-length S global pandemic glycoprotein humoral IFN-γ IgG IgG antibodies IgG antibody IL-2 immune response immune responses immunization immunogenic in viral induce injection intramuscular long-lasting Measures memory memory T mice mouse model NAb neutralizing antibody Pathogenesis plasmid DNA preclinical (in vivo) studies Prophylactic Protective protective immunity Protein response robust Safe SARS-CoV-2 significant level significantly spike (S) glycoprotein synthetic T cell Th1 the vaccine therapeutic TNF Vaccine was tested [DOI] 10.3389/fmicb.2021.727455 PMC 바로가기 [Article Type] Microbiology
Late reinfection with a different severe acute respiratory syndrome coronavirus-2 clade in a patient with refractory arterial hypertension: a case reportCase Report Published on 2021-09-062022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Antibody Response Arterial hypertension cardiometabolic Case report clade Comorbidities Comorbidity Complete coronavirus coronavirus disease Coronavirus-2 COVID-19 dataset described determinant diagnosed Evidence First wave Frequency Genome sequencing genomic Immunity Infection infections information initial male occurred pandemic Patient polymerase chain Primary infection protective immunity raise Reinfection reported risk risk factor SARS-CoV-2 serology Spain the patient viral shedding [DOI] 10.1186/s13256-021-03071-2 PMC 바로가기 [Article Type] Case Report
Assessment of avidity related to IgG subclasses in SARS-CoV-2 Brazilian infected patientsSARS-COV-2 브라질 감염 환자의 IgG 서브 클래스와 관련된 열성 평가Clinical Trial Published on 2021-09-032022-08-13 Journal: Scientific Reports [Category] SARS, 임상, 진단, 치료기술, [키워드] analyzed anti-RBD Anti-RBD IgG anti-RBD IgG4 antibody Antibody avidity antibody levels Antibody Response Applied immunology assessment association avidity avidity range Brazil COVID-19 detectable Diagnostic markers died disease effort elicit ELISA exacerbated Follow-up form Health highlighting hospitalized patient hospitalized patients house IgG IgG antibody IgG subclasse IgG1 IgG3 IgG4 Immunological response Immunological techniques indicate infected patient Laboratory less life-threatening Mild Mild disease Most patients outcome Patient predict protective immunity RBD RBD IgG RBD IgG-ELISA RBD protein resulting reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD sensibility sera severe COVID-19 specificity study period symptomatic patient Symptomatic patients symptoms onset the disease Vaccine development with COVID-19 with mild disease [DOI] 10.1038/s41598-021-95045-z PMC 바로가기 [Article Type] Clinical Trial
Persistence assessment of SARS-CoV-2-specific IgG antibody in recovered COVID-19 individuals and its association with clinical symptoms and disease severity: A prospective longitudinal cohort study회복된 COVID-19 개인에서 SARS-CoV-2-특이적 IgG 항체의 지속성 평가 및 임상 증상 및 질병 중증도와의 연관성: 전향적 종단 코호트 연구Article Published on 2021-09-012022-09-11 Journal: International immunopharmacology [Category] MERS, SARS, 바이오마커, 진단, [키워드] addition antibody antibody persistence Antibody titer association clinical symptom Clinical symptoms correlated COVID-19 COVID-19 infection demonstrated diagnosing diagnostic diagnostic test disease disease severity Evidence examined help helping Host humoral immune response humoral immune responses IgG antibody immune responses individual invading pathogen longitudinal cohort study marker Mild moderate MONITOR Neutralizing no decrease pandemic pathogen Pathogens persistence protective immunity provide PSO raise Re-infection real-time RT-PCR recruited robust SARS-CoV-2 SARS-CoV-2-specific IgG serological test Serological tests serum severity Spread subject Support Symptom symptom onset tested vaccination Vaccine development were measured [DOI] 10.1016/j.intimp.2021.107893 PMC 바로가기 [Article Type] Article