SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself중증 COVID-19의 SARS-CoV-2는 자신을 표적으로 삼지 않는 TGF-β가 우세한 만성 면역 반응을 유도합니다Article Published on 2021-03-302022-09-12 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, 치료법, [키워드] Adaptive immune response antibodies Antimicrobial responses B cell response B cell responses bind Blood COVID-19 patient COVID-19 patients Deceased dominant dominant antigen Express expression Gene Expression gene signature gene signatures Humoral immunity IFN IgA antibodies IgA antibody IgA2 IgG1 IL-21 immune reaction immune response induce inefficient instruction intensive care interferon lung Lungs Next-generation sequencing Pathogenesis Patient plasmablast plasmablasts reflect SARS-CoV-2 SARS-CoV-2 antigens SARS-CoV-2 spike protein Seroconversion severe COVID-19 severe COVID-19 patients single cell level Spike protein sustained TGF-β TGFβ Trigger viral infection [DOI] 10.1038/s41467-021-22210-3 PMC 바로가기 [Article Type] Article
Human milk banks in the response to COVID-19: a statement of the regional human milk bank network for Southeast Asia and beyondCommentary Published on 2021-03-292022-10-30 Journal: International Breastfeeding Journal [Category] COVID-19, [키워드] aligned Asia Bank Breastfeeding breastmilk Care Clinical management Community Contact country COVID-19 COVID-19 pandemic Donor donor human milk Evidence Guidance highlight Human human milk Human milk bank implementation Insufficient lack management milk National national guideline network Newborn Obstetric pandemic pasteurization recommendation reflect Regional Regional network Safe Seven supplementary material sustained Transmission WHO World Health Organization [DOI] 10.1186/s13006-021-00376-2 PMC 바로가기 [Article Type] Commentary
Masks, mechanisms and Covid-19: the limitations of randomized trials in pandemic policymaking마스크, 메커니즘 및 Covid-19: 전염병 정책 결정에서 무작위 시험의 한계Article Published on 2021-03-252022-09-11 Journal: History and philosophy of the life sciences [Category] SARS, 임상, [키워드] approach contrary COVID-19 Evidence expected Factor failure limitation Mask Masks mechanism offset pandemic Pandemics positive randomized control trial Randomized control trials Randomized control trials. randomized trial RCT RCTs reduce reflect required Transmission trials [DOI] 10.1007/s40656-021-00403-9 PMC 바로가기 [Article Type] Article
Political Identity Over Personal Impact: Early U.S. Reactions to the COVID-19 PandemicPsychology Published on 2021-03-232022-10-31 Journal: Frontiers in Psychology [Category] COVID-19, [키워드] Affect American analyzed Attitude belief carried COVID COVID-19 COVID-19 pandemic distress Effect emotional Factor Government identity implication individual management over pandemic personal impact Pew polarization political identity reaction reflect reported Research response responses Result suffered Support turn W64 [DOI] 10.3389/fpsyg.2021.607639 PMC 바로가기 [Article Type] Psychology
Should policy makers trust composite indices? A commentary on the pitfalls of inappropriate indices for policy formationResearch Published on 2021-03-222022-10-31 Journal: Health Research Policy and Systems [Category] COVID-19, SARS, [키워드] analyses Analysis build Community comparison Composite indicators coronavirus disease country data sets death rate Decision tools evidenced expected global health Heuristics identify index management methodological network observation pandemic pandemic preparedness Pandemics predict predicted provide question raised reflect Result Science Science-for-policy Scientific uncertainty security selected Spread suggested [DOI] 10.1186/s12961-021-00702-4 PMC 바로가기 [Article Type] Research
Assessing Interventions against Coronavirus Disease 2019 (COVID-19) in Osaka, Japan: A Modeling StudyArticle Published on 2021-03-182022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] applied Assessing Control coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 pandemic effective Epidemic Epidemiology estimation First wave illness onset implementation indicated Infection Intervention mathematical model Measures modeling multiple intervention outcome public health reduce reducing reductions in reflect Reproduction number second wave severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the epidemic [DOI] 10.3390/jcm10061256 PMC 바로가기 [Article Type] Article
A Commentary on Realities of Developing COVID-19 Vaccines Discussed through the Global Health Safety PerspectiveCommentary Published on 2021-03-182022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] addition addressed Affect affecting clinical trial COVID-19 COVID-19 vaccine develop Developing disease effective Efficiency effort explain global health global pandemic globe Health health safety perspective Health status Infection measure Perspective possible concerns potential risk realities REALITY reflect Safety SARS-CoV-2 Scientific community scientist Side effect Treatment vaccination Vaccine virus [DOI] 10.3390/vaccines9030274 PMC 바로가기 [Article Type] Commentary
SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19인간 iPSC 유래 심장 세포의 SARS-CoV-2 감염은 COVID-19 환자의 심장에서 세포변성 특징을 반영합니다Reports Published on 2021-03-152022-09-10 Journal: Science Translational Medicine [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alterations Asymptomatic Autopsy autopsy specimens cardiac damage cause Cell consequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytopathic damage dysfunction exposure feature heart Human Infection leads morphologic features Morphological nuclear offer Pathogenesis Patient patients patients with COVID-19 platform raise reflect reflected respiratory robust SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe cases specimen stem cell transcriptomic [DOI] 10.1126/scitranslmed.abf7872 PMC 바로가기 [Article Type] Reports
The Good Treatment, the Bad Virus, and the Ugly Inflammation: Pathophysiology of Kidney Involvement During COVID-19Physiology Published on 2021-03-112022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] ACE2 AKI (acute kidney injury) antiviral drug association Autopsy biopsies cells COVID COVID-19 COVID–19 critically ill patients cytopathogenic effect described direct viral infection endothelial cells ENhance event Good help highlight immunomodulators Infection Inflammation Involvement kidney kidneys mechanism Multi-organ damage observational studies organ dysfunction outcomes pathophysiological hypotheses Perspective raise reflect renal renal damage responsible SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection sequence Spread Structure synergy systemic inflammation target Therapeutic strategies tissue TMPRSS2 viral invasion viral pathogenicity viral sepsis virus while [DOI] 10.3389/fphys.2021.613019 PMC 바로가기 [Article Type] Physiology
An Overview on the Development of mRNA-Based Vaccines and Their Formulation Strategies for Improved Antigen Expression In VivoReview Published on 2021-03-112022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] administration animal models approach current development Electroporation form Formulation Human Improved improvement in vivo IVT mRNA LNPs malignancy mRNA mRNA vaccine mRNA-based vaccine outcome overcome platform protamine reflect reported secure Strategy therapeutic use Vaccine [DOI] 10.3390/vaccines9030244 PMC 바로가기 [Article Type] Review