Therapeutic strategies – Page 17 – Communicable Diseases Research

SARS-Cov-2 Interactome with Human Ghost Proteome: A Neglected World Encompassing a Wealth of Biological Data

Communication

Published on 2020-12-192022-10-29
Journal: Microorganisms [Category] COVID-19,

Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

지질 방울은 SARS-CoV-2 복제 및 염증 매개체 생성을 촉진합니다

Research Article

Published on 2020-12-162022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 치료법,

[키워드] addition Analysis Antiviral biosynthetic CD36 Cell cell death cellular metabolism complex component contribute COVID-19 COVID-19 pandemic COVID-19 patient demonstrated described develop disease donors double-stranded droplet effort electron microscopy energy homeostasis ENhance enzyme expression function homeostasis Host host cell host cells host immunity human cell lines infected cells Infection Inflammation inflammatory mediator inhibited LDs Lipid lipid droplet lipid droplets lipid metabolism mechanism mediator mediators metabolism modulate modulation monocyte Monocytes organelle parasite Pathogenesis pathway Pathways Perspective pharmacological platform PPARγ pro-inflammatory response Protein recruit recruited reduce reduced Regulation Replication RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 replication SARS-CoV2 SARS-CoV2 infection significantly Support target therapeutic intervention Therapeutic strategies therapeutic strategy Transport triggered Vero Cell Vero cells Viral viral particle Viral particles viral replication virus virus replication viruses
[DOI] 10.1371/journal.ppat.1009127 PMC 바로가기 [Article Type] Research Article

Detection of SARS-CoV-2 pneumonia: two case reports

SARS-CoV-2 폐렴 진단: 2건의 사례 보고

Case Reports

Published on 2020-12-112022-09-10
Journal: Journal of Medical Case Reports [Category] MERS, SARS, 진단, 치료기술,

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

비교 호스트 코로나 바이러스 단백질 상호 작용 네트워크는 범 바이러스 질병 메커니즘을 나타냅니다

Comparative Study

Published on 2020-12-042022-09-10
Journal: Science (New York, N.y.) [Category] MERS, SARS, 유전자 메커니즘, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed Antisera approach approaches asked Atypical carried caused Celecoxib cellular chaperone Characteristics characterized clinical outcomes clinical study clinically Cohort Comparative Comparative analysis complex conducted conserved coronavirus COVID-19 COVID-19 hospitalization COVID-19 pandemic COVID-19 patient curated dataset determine develop disease drug drug target drug treatment Effectiveness effort Endoplasmic reticulum engage ENhance Evidence Factor functional Genetic genetic data genetic screening genetic screens Genome-wide association study Genotype genotypes Hospitalization Host Host immune response host protein hosts human cells human coronaviruses human protein Hypothesis Hypothesis testing identify IL17RA independent individual indomethacin Infection infectious agent infectious agents inhibit inhibit SARS-CoV-2 inhibitor interact Interaction investigated left less life cycle Localization mapped mechanism MERS MERS-CoV Microscopy Middle East Middle East respiratory syndrome Coronavirus mitochondrial modulate molecular molecular mechanism molecular mechanisms NSP open Open reading frame ORF Orf9b Outbreaks pathogenic coronavirus pathogenic human coronavirus pathogenic human coronaviruses pathway patient data patients treated plasma proliferation Protein protein-protein interaction provide public health raised receptor receptors respiratory respiratory syndrome coronavirus right risk risk of COVID-19 SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 ORF9b SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 replication Science selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shedding SIGMAR1 significant changes in strain Strains Structure subset target targets tested Therapeutic strategies Therapeutics therapy urgency utility Viral viral infection Viral protein Viral proteins virus Virus life cycle virus strain viruses
[DOI] 10.1126/science.abe9403 PMC 바로가기 [Article Type] Comparative Study

Complications and Pathophysiology of COVID-19 in the Nervous System

Neurology

Published on 2020-12-042022-11-01
Journal: Frontiers in Neurology [Category] COVID-19,

SARS-CoV-2 receptor networks in diabetic and COVID-19-associated kidney disease

당뇨병 및 COVID-19 관련 신장 질환의 SARS-CoV-2 수용체 네트워크

Article

Published on 2020-12-012022-09-11
Journal: Kidney international [Category] SARS, 유전자 메커니즘,

[키워드] ACE ACE inhibitors ACE2 ACE2 expression ACE2 receptor acute kidney Acute kidney injury aldosterone Alter angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bayesian biopsy Cell cellular COVID-19 dataset diabetes Diabetic diabetic kidney diabetic nephropathy Donor endomembrane epithelial epithelial cell epithelial cells expression expression pattern expression patterns healthy hospitalized patient host cells immune activation In situ hybridization infected cells Infection inhibitor Integrative analysis investigated kidney kidney damage Kidney disease kidneys living donors mechanism medication medications molecular molecular networks morbidity morbidity and mortality overlapped Patient patients with diabete proximal proximal tubules Renin renin-angiotensin-aldosterone system Research risk stratification RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2-infected cells scRNAseq susceptibility the SARS-CoV-2 Therapeutic strategies therapeutic strategy Urine Viral viral entry with COVID-19
[DOI] 10.1016/j.kint.2020.09.015 PMC 바로가기 [Article Type] Article

COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes

COVID-19 심각도는 CD1c+ DC 및 염증성 이행 및 비고전 단핵구의 폐 재분포와 관련이 있습니다.

Clinical Trial

Published on 2020-12-012022-08-31
Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 바이오마커, 임상,

[키워드] Activation acute respiratory distress acute respiratory distress syndrome addition Antiviral ARDS association Blood CD1c CD8+ T cell CD8+ T cells characterized Clinical severity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient COVID-19 severity critical COVID-19 patients dendritic cell dendritic cells disease dysregulated immune response dysregulated immune responses frequencies Frequency healthy individuals immune responses immunology increase infected individuals Inflammation Inflammatory involved knowledge life-threatening lung lung infiltrate lung infiltrates Lungs Mild symptom mild symptoms monocyte Monocytes myeloid cell occur Pathogenesis pathogenesis of COVID-19 Patient profile progression respiratory distress Respiratory distress syndrome responsible SARS-CoV-2 SARS-COV-2 infection severe COVID-19 subpopulation subset syndrome T cell T cells Therapeutic strategies therapeutic strategy Viral viral control
[DOI] 10.1172/JCI140335 PMC 바로가기 [Article Type] Clinical Trial

Modeling the Molecular Impact of SARS-CoV-2 Infection on the Renin-Angiotensin System

레닌-안지오텐신 시스템에 대한 SARS-CoV-2 감염의 분자 영향 모델링

Article

Published on 2020-11-302022-09-01
Journal: Viruses [Category] SARS, 진단,

[키워드] ACE2 acute respiratory distress syndrome angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding Clinical data Clinical outcome coronavirus coronavirus disease COVID-19 COVID-19 patients downregulation drug drugs dysregulation effective healthy hypertensive hypothese hypotheses Impact in silico individuals mathematical mathematical model mathematical modeling modeling normotensive pathogenic mechanism pathogenic mechanisms peptide predict predicted Protein RAS RAS-blockers recombinant ACE2 Renin renin angiotensin system renin-angiotensin system risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection Spike protein System Therapeutic strategies Viral Viral load was tested with COVID-19 worsening
[DOI] 10.3390/v12121367 PMC 바로가기 [Article Type] Article

Human induced pluripotent stem cells as a tool for disease modeling and drug screening for COVID-19

Articles

Published on 2020-11-162022-10-31
Journal: Genetics and Molecular Biology [Category] COVID-19,

Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2

Article

Published on 2020-11-162022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19,

[키워드] Activation acute respiratory syndrome addition Analysis approach arachidonic acid AUC Biomarkers characterized circulating control groups coronavirus correlated COVID-19 COVID-19 patient death Degradation Effect Evidence fatty acids free fatty acids Host host response Infection key factor Lipid mechanism metabolism metabolomic metabolomics molecule New Pathogenesis pathogenesis of COVID-19 Phosphatidylcholine Phospholipase A2 plasma porphyrins potential biomarkers provide provided response Revealed SARS-CoV-2 SARS-COV-2 infection severity spread to target the disease Therapeutic strategies therapeutic target therapeutic targets Triglyceride tyrosine
[DOI] 10.3390/ijms21228623 PMC 바로가기 [Article Type] Article