Programmed Death (PD)-1-Deficient Mice Are Extremely Sensitive to Murine Hepatitis Virus Strain-3 (MHV-3) Infection
Research Article
[키워드] activate
anti-IFN-γ
anti-TNF-α
Author
blockade
cascades
CD4
CD8
cells
characteristic
co-expressed
Coagulation
Combination
Control
damaged
demonstrated
described
determined
exhibited
expression
Fgl2
FH
fibrinogen
Fluorescence
fulminant viral hepatitis
functional
hepatocellular
IFN-γ
immunopathological
immunopathological damage
Immunotherapy
in vivo
Infection
inhibitory receptor
initiate
injection
investigated
led to
limit
liver
Liver damage
Lymph node
lymph nodes
mAb
Macrophage
maintain
mechanism
mice
Mortality
mortality rate
mRNA
multiple organs
murine hepatitis virus
Necrosis
NK cell
occurred
organ
Pathogenesis
peripheral tolerance
produced
promote
Protein
Quantitative
reduced
related
RT-PCR
sensitive
Signaling
significantly higher
spleen
T cells
tissue
tissue damage
tissue lesion
tissue lesions
TNF-α
Transcription
was determined
wild type
wild-type
[DOI] 10.1371/journal.ppat.1001347 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1001347 PMC 바로가기 [Article Type] Research Article