An assessment of the level of concern among hospital-based health-care workers regarding MERS outbreaks in Saudi ArabiaResearch Article Published on 2017-01-032022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, [키워드] addition addressed Affect affected age Attitude average calculated Care caused concern covariates disease distinct domains Effectiveness effort evaluated FIVE Government HCW HCWs health-care health-care worker hospital hospitals identify majority management MERS MERS coronavirus MERS-CoV MERS-CoV infection Middle East Mortality Multiple National Nurses occurred outbreak outcome participant Patient precautions predictor questionnaire regression analysis reported respiratory Result risk Safe Saudi Arabia severity significantly the disease Travel virus were assessed were used [DOI] 10.1186/s12879-016-2096-8 PMC 바로가기 [Article Type] Research Article
Predicting the international spread of Middle East respiratory syndrome (MERS)Research Article Published on 2016-07-222022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, [키워드] AIC Airline transportation network Akaike information criterion Analysis analyzed Area assumed AUC calculated coronavirus country covariate distribution effective estimate facilitated help highest importation IMPROVE incidence Infectious disease Intensive International majority MERS MERS coronavirus Middle East Middle East respiratory syndrome Muslim predict Predictive reported Result risk Risk assessment Saudi Arabia sensitivity skewed specificity Spread statistical model Support syndrome Transmissibility Transmission model were used [DOI] 10.1186/s12879-016-1675-z PMC 바로가기 [Article Type] Research Article
Development of an indirect ELISA, blocking ELISA, fluorescent microsphere immunoassay and fluorescent focus neutralization assay for serologic evaluation of exposure to North American strains of Porcine Epidemic Diarrhea VirusMethodology Article Published on 2015-08-012022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] addition Analysis antibody Asia asked assays biotinylated calculated colostrum Coronaviruses correlation country cross-reactivity demonstrated described develop development diagnostic test Disadvantages ELISA epidemic diarrhea expressed fluorescent Fluorescent Focus Neutralization (FFN) Fluorescent microsphere immunoassay (FMIA) functional gastroenteritis highlight IFA Immune status immunoassay immunohistochemistry Interpretation kappa value Laboratory mAb mAbs magnetic bead measurement microsphere MONITOR monoclonal monoclonal antibody multiple antigen naïve Neutralization assay Neutralizing antibodies neutralizing antibody Neutralizing antibody response North North America outbreak pathogen PEDV porcine epidemic diarrhea virus (PEDV) protective immunity quantitation question receiver operating characteristic recent Respiratory Coronavirus Result ROC ROC analysis Sensitivity and specificity Seroconversion Serological assay serology serum serum sample significant level Spread staining strain TGEV vaccine candidate virus virus neutralizing antibodies was performed were used [DOI] 10.1186/s12917-015-0500-z PMC 바로가기 [Article Type] Methodology Article
Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry비만의 유전자 × 신체 활동 상호 작용: 유럽 조상 111,421명의 통합 분석Research Article Published on 2013-07-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity Adult Adults age aggregate effect allele analyses analysis Analysis ancestry attenuate Author BMI calculated Characteristics Cohort cohorts Combined cumulative cumulative effect detected diminishe environmental exposure European Europeans Evidence evidence of examined FTO gene × environment interactions genetic risk genetic risk score Genetic variant Genome-wide association studies genotyped GRS heterogeneity Inclusion indicated individual inefficient inhibit Interaction interaction effect interactions knowledge Li linear loci locus logistic regression model meta-analyses meta-analysis Meta-analysis multicenter Multiplicative interaction Multiplicative interactions North North America nucleotide Numerous obesity Participants physical activity provide Questionnaires replicated Replication reported Sample size SEC16B Secondary analyses Sex single nucleotide polymorphisms SNP SNP × physical activity interactions statistically significant Support tested treated variant [DOI] 10.1371/journal.pgen.1003607 PMC 바로가기 [Article Type] Research Article
SWIFT: Prospective 48-Week Study to Evaluate Efficacy and Safety of Switching to Emtricitabine/Tenofovir From Lamivudine/Abacavir in Virologically Suppressed HIV-1 Infected Patients on a Boosted Protease Inhibitor Containing Antiretroviral RegimenSWIFT: 항레트로바이러스 요법을 포함하는 강화된 프로테아제 억제제를 사용하는 바이러스학적으로 억제된 HIV-1 감염 환자에서 라미부딘/아바카비르에서 엠트리시타빈/테노포비어로 전환하는 것의 효능 및 안전성을 평가하기 위한 전향적 48주 연구HIV/AIDS Published on 2013-06-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] 3TC/ABC 95% confidence interval abacavir addition Arm ARMS backbone baseline characteristics calculated CD4 Characteristics cholesterol compared Containing Decline decrease Decreased defined Efficacy and safety EGFR emtricitabine emtricitabine/tenofovir epidermal epidermal growth factor evaluate FTC/TDF fumarate GFR greater growth factor HIV patient HIV patients HIV-1 Human immunodeficiency virus immunodeficiency virus improvement Improvements Infected inhibitor lamivudine LDL Lipid lipids Lipoproteins Low-density lipoprotein low-density lipoproteins male median median age nucleoside Open-label parameter Patient PI primary endpoint Prospective Protease inhibitor Randomized rebound receiving receptor regimen reverse transcriptase risk score Ritonavir RNA RTV Safety study drug subject suppressed switch switching tenofovir disoproxil fumarate TG The United States threshold Total cholesterol transcriptase treated treatment difference Triglyceride triglycerides United States virologic failure Virologic suppression [DOI] 10.1093/cid/cis1203 PMC 바로가기 [Article Type] HIV/AIDS
Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals공통 변이체는 매우 작은 개체를 제외하고 분포 꼬리의 키에 대한 예측된 다유전자 효과를 보여줍니다Research Article Published on 2011-12-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major allele Author average calculated chance classic cohorts common common disease common variants complex decrease determine discrepancy distribution Effect effect size Effects effort expectation expected explain explained extreme Factor found fraction Frequency Genetic Genetic variant Genetic variation Height Human genome implication include individual individuals less loci low frequency Odds ratio Odds ratios phenotype Phenotypes population-based cohort Predictive quantitative traits short stature show shown significantly stature tail trait traits variant variants Variation whole-exome sequencing whole-genome [DOI] 10.1371/journal.pgen.1002439 PMC 바로가기 [Article Type] Research Article
Spatial patterns of Bovine Corona Virus and Bovine Respiratory Syncytial Virus in the Swedish beef cattle populationResearch Published on 2010-05-212022-10-28 Journal: Acta Veterinaria Scandinavica [Category] Coronavirus, [키워드] an area analyzed animal antibody Area autocorrelation BCV blood sample bovine Bovine coronavirus calculated carried Cluster Clusters collected Corona cross-sectional detected effective expected found geographical distribution indicated Infection infections performed positive presence of antibody Prevalence regions respiratory respiratory syncytial virus Result risk risk factor serological survey shown significantly higher survey Swedish Variation was performed [DOI] 10.1186/1751-0147-52-33 PMC 바로가기 [Article Type] Research
Factors associated with nosocomial SARS-CoV transmission among healthcare workers in Hanoi, Vietnam, 2003Research Article Published on 2006-08-142022-10-28 Journal: BMC Public Health [Category] Coronavirus, [키워드] 2003 95% confidence interval activity Analysis antibody assigned attack rate calculated Care Case-control category collected Community coronavirus cough detected disease Evidence Factor Fever group healthcare worker help highest highlight Hong Kong hospital implication increased risk individuals Infection Influenza lowest nosocomial Nurse occurred other respiratory infection outbreak Patient recommendation reported respiratory Result risk risk factor SARS-CoV SARS-CoV infection serologic serum severe specimen Spread subsequent Symptom the patient Transmission Univariate analysis was performed [DOI] 10.1186/1471-2458-6-207 PMC 바로가기 [Article Type] Research Article
Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003Research Article Published on 2004-09-062022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] 2003 3CLpro adjusted Analysis antigenic antigenic protein appear arising calculated Cell culture China Co-infection Complete Contact Culture cultured isolate Deletion different estimate FIVE found functional Gene Genes Genetic Genome greater group growth hotel human population human populations human tissue human-to-human transmission in vitro in vivo isolate isolates molecular Mutation mutation rate Non-synonymous mutation North nucleotide substitution ORF ORFs passage pathogen Patient per day polymerase Proteins related respiratory Result RNA virus SARS Coronavirus SARS-CoV selection pressure sequence sequenced severe Singapore Taiwan the epidemic the SARS epidemic tissue sample Transmission transmission patterns undergo Vero Cell viral genome was used whole genome sequence [DOI] 10.1186/1471-2334-4-32 PMC 바로가기 [Article Type] Research Article