Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial항레트로바이러스 요법(REALITY)을 시작하는 아프리카의 심각한 면역 저하 HIV 감염 개인의 사망률에 대한 즉시 사용 가능한 보충 식품의 효과: 공개, 병렬 그룹, 무작위 대조 시험Article Published on 2018-04-102022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 1:1 95% CI adverse event adverse events age analysed anti-infection Antiretroviral therapy ART assigned block size BMI body-mass body-mass index both groups CD4 cell Cell changes in children clinic visit Clinic visits computer-generated database Department development died Dispensing Effect eight Eligible participants Evidence evidence of finding funding global health GRADE greater hazard ratio high risk HIV infection hospital hypothesise Immunocompromised in both group individual individuals infected individuals infections Intention intention to treat Interaction ISRCTN ISRCTN registry Kenya log-rank Medical Research Council medication micronutrients Mortality no evidence of nutritional status Older Open-label outcome parallel-group participant Participants peanut per day Policy present Primary outcome Prophylaxis raltegravir randomisation randomised controlled trial Randomly ready-to-use therapeutic food reducing Registered reported Safety secondary Secondary outcomes Serious Adverse Event Serious Adverse Events significantly stratified sub-Saharan Africa Symptom Trial Uganda vital status weight weight gain Wellcome Trust would increase Z score Zimbabwe [DOI] 10.1016/S2352-3018(18)30038-9 PMC 바로가기 [Article Type] Article
Causes and Timing of Mortality and Morbidity Among Late Presenters Starting Antiretroviral Therapy in the REALITY TrialREALITY 임상시험에서 항레트로바이러스 치료를 시작한 후기 발표자의 사망률과 이환율의 원인과 시기Advanced HIV Disease Published on 2018-04-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] advanced disease Africa albendazole anti-infection Antiretroviral therapy ART Azithromycin Bacterial infection blinded cause causes CD4 clinical cotrimoxazole cryptococcosis death declined died enhanced event events fluconazole highlight HIV incidence Infection infections isoniazid median morbidity Mortality occurred participant Participants pre-ART CD4 presenter Prophylaxis randomized trial REALITY reduced Registration Result severe immunosuppression starting sub-Saharan Africa Tuberculosis unknown causes [DOI] 10.1093/cid/cix1141 PMC 바로가기 [Article Type] Advanced HIV Disease
Late Presentation With HIV in Africa: Phenotypes, Risk, and Risk Stratification in the REALITY Trial아프리카에서 HIV에 대한 늦은 발표: REALITY 시험의 표현형, 위험 및 위험 계층화Advanced HIV Disease Published on 2018-04-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] Africa age albumin Antiretroviral therapy ART baseline CD4 CD4 count CD4 counts children clinical Cox regression died enrolled Fat mass Fever FIVE Follow-up grip strength group Health Organization hemoglobin high mortality highest HIV Human immunodeficiency virus identify Immunocompromised Immunosuppression individual infected individuals Intensive investigated Kenya laboratory feature median Mobility Mortality neutrophil neutrophil count neutrophil counts Older Older age Participants Patient Phenotypes Platelet poor mobility predictor presentation problem problems Prophylaxis reduced Registration remaining group Result self-care symptom burden Trial Uganda vomiting weight loss white cell World Health Organization Zimbabwe [DOI] 10.1093/cid/cix1142 PMC 바로가기 [Article Type] Advanced HIV Disease
Detection of viral respiratory pathogens in mild and severe acute respiratory infections in SingaporeArticle Published on 2017-02-202022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Acute respiratory infection added analysed ARI chain clinical Cohort Community declined decrease detection Diagnosis evaluate excluded faster hospital Influenza Inpatient Inpatients Laboratory Mild multiplex Nasopharyngeal swab Older Participants pathogen PCR performed presenting Prospective Study reaction respiratory virus Respiratory virus infections RT-PCR Severe case Singapore Surveillance tested viral pathogen viral respiratory virus [DOI] 10.1038/srep42963 PMC 바로가기 [Article Type] Article
Cross‐sectional survey and surveillance for influenza viruses and MERS ‐CoV among Egyptian pilgrims returning from Hajj during 2012‐2015Short Article Published on 2016-11-112022-10-30 Journal: Influenza and Other Respiratory Viruses [Category] Coronavirus, MERS, [키워드] collected conducted cough Coverage Egypt Egyptian Hajj help identify ILI IMPROVE Influenza influenza virus Influenza virus influenza viruses MERS MERS‐Coronavirus Ministry of Health Oropharyngeal participant Participants Population positive Prevalence reported respiratory symptom risk specimen Surveillance Swab tested vaccination Vaccine was tested [DOI] 10.1111/irv.12429 PMC 바로가기 [Article Type] Short Article
A cluster randomized controlled trial to increase the availability and acceptability of voluntary medical male circumcision in Zambia: The Spear and Shield Project잠비아에서 자발적인 의료 남성 할례의 가용성과 수용 가능성을 높이기 위한 클러스터 무작위 대조 시험: The Spear and Shield ProjectArticle Published on 2015-06-172022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 95% CI adjusted odds ratio adverse event adverse events assigned baseline Care center Cluster community health Community health centers conditions conducted Control Controlled trial counseling death expressed female finding funding Health Health care HIV HIV infection HIV prevention Intervention likelihood male men MOST Odds ratio participant Participants Participation Patient performed post-intervention Prevalence prevention programs Primary outcome randomization Randomized controlled trial Randomly reported Result Shield significant increase Spear statistician stratified study participation supply Support tested Trial registration [DOI] 10.1016/S2352-3018(15)00042-9 PMC 바로가기 [Article Type] Article
Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry비만의 유전자 × 신체 활동 상호 작용: 유럽 조상 111,421명의 통합 분석Research Article Published on 2013-07-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity Adult Adults age aggregate effect allele analyses analysis Analysis ancestry attenuate Author BMI calculated Characteristics Cohort cohorts Combined cumulative cumulative effect detected diminishe environmental exposure European Europeans Evidence evidence of examined FTO gene × environment interactions genetic risk genetic risk score Genetic variant Genome-wide association studies genotyped GRS heterogeneity Inclusion indicated individual inefficient inhibit Interaction interaction effect interactions knowledge Li linear loci locus logistic regression model meta-analyses meta-analysis Meta-analysis multicenter Multiplicative interaction Multiplicative interactions North North America nucleotide Numerous obesity Participants physical activity provide Questionnaires replicated Replication reported Sample size SEC16B Secondary analyses Sex single nucleotide polymorphisms SNP SNP × physical activity interactions statistically significant Support tested treated variant [DOI] 10.1371/journal.pgen.1003607 PMC 바로가기 [Article Type] Research Article
Equivalence of Self- and Staff-Collected Nasal Swabs for the Detection of Viral Respiratory PathogensResearch Article Published on 2012-11-142022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Acute respiratory infection approaches ARI collected compared Concentration conducted detected detection diagnostic DNA DNA concentration Epidemiology equivalence finding Germany Human human coronavirus OC43 multiplex nasal swab nasal swabs nostril participant Participants pathogen pathogen detection Pathogens Prospective Study Quality control reported respiratory respiratory pathogen respiratory viral rhinovirus RT-PCR self Self-swab subsequent Swab swabbing swabs symptomatic Symptoms viral respiratory was determined Weekly β-actin [DOI] 10.1371/journal.pone.0048508 PMC 바로가기 [Article Type] Research Article
SARS Molecular Detection External Quality AssuranceDispatch Published on 2004-12-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] coronavirus detected detection dispatch External NAT network outcome Participants PCR Quality Quality assurance reference RNA copy SARS significantly verification virus were used WHO World Health Organization [DOI] 10.3201/eid1012.040416 PMC 바로가기 [Article Type] Dispatch