MERS-CoV geography and ecology in the Middle East: analyses of reported camel exposures and a preliminary risk mapResearch Article Published on 2015-12-182022-10-27 Journal: BMC Research Notes [Category] Coronavirus, [키워드] Analysis analysis approach breadth Camel condition Contact dimension distribution ecological ecological niche environmental condition Host human infections indicated less MERS MERS-CoV MERS-CoV transmission middle Middle East occur occurred Occurrence offer Quantitative reported Reservoir host respiratory syndrome coronavirus Result risk Risk map Spread the disease Transmission virus [DOI] 10.1186/s13104-015-1789-1 PMC 바로가기 [Article Type] Research Article
Infectious Bronchitis Virus as a Vector for the Expression of Heterologous GenesResearch Article Published on 2013-06-262022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] analysed assays avian coronavirus bronchitis cells chick compared demonstrated eGFP expressed expressing expression fluorescence microscopy fluorescent Gene generate Genetic genetics Genome Heterologous IBV increase in Infection infectious Infectious Bronchitis Virus intergenic region kidney luciferase activity MOI offer ORF Pathogens Protein recombinant Renilla luciferase replaced replacing reporter reporter gene rescued Respiratory disease stability utilised vaccination Vaccine vector [DOI] 10.1371/journal.pone.0067875 PMC 바로가기 [Article Type] Research Article
Immunoreactivity characterisation of the three structural regions of the human coronavirus OC43 nucleocapsid protein by Western blot: Implications for the diagnosis of coronavirus infectionArticle Published on 2012-11-192022-11-01 Journal: Journal of virological methods [Category] Coronavirus, MERS, [키워드] Adults antibody Antigen antigenicity Betacoronavirus Blood blood sample C-terminal domain characterisation Coronavirus infection cross-react demonstrated detected antibody Diagnosis diagnostic different E, Envelope Elderly patient epidemiological evaluated greater HCoV-229E HCoV-OC43 HCoV-OC43, human coronavirus OC43 Human coronavirus human coronavirus OC43 human CoV human serum humans identify immune response immunoreactivity Infection IPTG, β-d-1-thiogalactopyranoside M, matrix N-terminal domain NP, nucleocapsid protein nucleocapsid protein OC43 strain occur offer patients polyclonal polyclonal antibody previous study produced Protein purified rabbit polyclonal antibody reactivity Region reported respiratory infection RNP, ribonucleoprotein S, spike SARS-CoV serum serum sample specificity SPR, surface plasmon resonance Strong tested Variability virus infection [DOI] 10.1016/j.jviromet.2012.11.009 PMC 바로가기 [Article Type] Article
Stimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection작은 분자에 의한 숙주 면역 방어의 자극은 세균 감염으로부터 C. elegans를 보호합니다Research Article Published on 2012-06-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect analysis antibiotic Antibiotics ATF-7 Author Bacterial Bacterial infection Bacterial infections bacterial pathogen Bacterial pathogens Caenorhabditis elegan Caenorhabditis elegans cellular processe cellular processes Compound conserved effector molecule Efficacy elegan expression Gene Genes growth Host immune response host immunity identify immune immune regulators immunostimulatory Infection Interaction low molecular weight mechanism mechanism of action mode molecule molecules mutants nematode offer Pathogens pathway promote PROTECT Pseudomonas aeruginosa required small molecule Small molecules stimulate Stimulation tested therapy These data Transcription transcription factor Transcriptome Treatment variety [DOI] 10.1371/journal.pgen.1002733 PMC 바로가기 [Article Type] Research Article
Development of a recombinant truncated nucleocapsid protein based immunoassay for detection of antibodies against human coronavirus OC43 ☆Article Published on 2011-07-212022-11-01 Journal: Journal of virological methods [Category] Coronavirus, MERS, [키워드] Adults antibody Antigen cause clinical utility collected coronavirus coronavirus demonstrated detect development Diagnosis diagnostic ELISA enzyme evaluate evaluated HCoV-OC43 healthy Hospitalization Human human coronavirus OC43 human coronaviruses humans illness immunoassay immunosorbent Infection mild illness nucleocapsid nucleocapsid protein OC43 offer outbreak Patient patients positive Protein Respiratory virus infections responsible Result resulting screened Sensitivity and specificity serology serum serum sample specificity The diagnostic sensitivity upper respiratory tract while [DOI] 10.1016/j.jviromet.2011.07.005 PMC 바로가기 [Article Type] Article
A Novel Replication-Competent Vaccinia Vector MVTT Is Superior to MVA for Inducing High Levels of Neutralizing Antibody via Mucosal VaccinationResearch Article Published on 2009-01-132022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Antigen Chinese dissemination doses Efficacy experiments generate genomic location Head-to-head comparison implication Inducing inoculated intramuscular intranasal Level maintain mice mucosal neutralizing antibody novel offer Prevent protective immune response response S gene SARS-CoV SARS-CoV neutralizing antibody spike glycoprotein Superior Tian vaccination Vaccine vaccine candidate vaccinia variant vector Viral transmission Viral vector was used wild-type [DOI] 10.1371/journal.pone.0004180 PMC 바로가기 [Article Type] Research Article
DetectiV: visualization, normalization and significance testing for pathogen-detection microarray dataSoftware Published on 2007-09-142022-11-01 Journal: Genome Biology [Category] Coronavirus, [키워드] Analysis bioinformatics dataset DNA microarray experiment lack Microarray Normalisation offer statistical software R Visualisation [DOI] 10.1186/gb-2007-8-9-r190 PMC 바로가기 [Article Type] Software
Molecular mechanisms of severe acute respiratory syndrome (SARS)Review Published on 2005-01-202022-10-28 Journal: Respiratory Research [Category] Coronavirus, [키워드] acute respiratory syndrome approach caused contribute coronavirus Deleterious Effect effort Epidemics Features Genome Health immune immune system indirect effect infections Infectious disease Interaction Laboratory mechanism molecular mechanisms morbidity and mortality mutability Novel coronavirus Occurrence offer Open reading frame outbreak Pathogenesis Prevent pulmonary pathological Region required Research Respiratory disease SARS SARS-CoV severe Severe acute respiratory syndrome target cell the disease therapy vaccination Vaccine viral genome virulence virus widespread [DOI] 10.1186/1465-9921-6-8 PMC 바로가기 [Article Type] Review
Atypical SARS and Escherichia coli BacteremiaDispatch Published on 2004-02-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome Atypical atypical severe acute respiratory syndrome Bacteremia Chest clinical symptom Cluster Contact diagnosed dispatch Escherichia coli healthcare worker highlight Hospitalized infection control offer Patient problem Respiratory failure SARS [DOI] 10.3201/eid1002.030501 PMC 바로가기 [Article Type] Dispatch