treat – Page 178 – Communicable Diseases Research

Sambucus nigra extracts inhibit infectious bronchitis virus at an early point during replication

Research Article

Published on 2014-01-162022-10-28
Journal: BMC veterinary research
[Category] Coronavirus,

Global Analysis of the Sporulation Pathway of Clostridium difficile

Clostridium difficile의 포자 형성 경로에 대한 글로벌 분석

Research Article

Published on 2013-08-082022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] activated activating Activation Analysis Antibiotics Author B. subtilis Bacillus subtilis Clostridia Clostridium Clostridium difficile Colitis Complication determine determined diagnostic biomarker Diagnostic biomarkers diarrhea expression Factor firmicutes framework function Gene gene product Genes genes encoding gram highlight identify Infection infectious infectious diarrhea lead life-threatening loss-of-function mutation loss-of-function mutations mechanism mutant organism pathogen Pathogenesis performed predicted provide pseudomembranous colitis question recurrence regulate regulated Regulatory regulatory pathway related required responsible Sequencing sigma spore spores sporulation Spread the United State Transcription transcriptional Transmission treat United States whole-genome
[DOI] 10.1371/journal.pgen.1003660 PMC 바로가기 [Article Type] Research Article

Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway

류마티스 관절염의 인간 유전학은 CD40 신호 전달 경로의 고처리량 약물 검사를 안내합니다

Research Article

Published on 2013-05-162022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] activated After allele Analysis approved drug Arthritis association Author B cells B lymphocyte B lymphocytes Biology can be used CD19+ CD40 CD40 ligand CD40 signaling Cell cell line chemical compounds clinical care coding Combination complex Compound consequence controls correlation counter deep sequencing develop disease drug Drug discovery drugs effort eQTL ExoN exonic explain expression finding Follow-up gain-of-function Genetic genetic findings Genome-wide association studies Genome-wide association study genotyping guide GWAS healthy control homozygous Human Human genetics identify implicated increase individuals Infection Inflammation inhibit inhibitor loci locus lymphocyte Lymphocytes mononuclear cell mononuclear cells mouse NF-kB NF-κB NF-κB signaling non-risk allele observé p65 pathway Patient Peripheral blood Peripheral blood mononuclear cells Phosphorylation Protein Quantitative RA RELA reporter retroviral Rheumatoid rheumatoid arthritis risk risk allele Screen second Sequencing seropositive Signaling single SNP small molecule Small molecules small-molecule screen subject subunit therapy trait traits transcription factor treat variant while
[DOI] 10.1371/journal.pgen.1003487 PMC 바로가기 [Article Type] Research Article

miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1

miR-199a-5p는 조직 손상에 대한 섬유성 반응 동안 상향 조절되고 카베올린-1을 표적으로 하여 TGF베타 유도 폐 섬유아세포 활성화를 매개합니다

Research Article

Published on 2013-02-142022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] a major Activation addition Author best Bile duct Biology Bleomycin CAV1 Cell cell type cellular cellular processes characterized chronic class complex diseases contributing to controls Critical current therapy demonstrated deregulation develop different differentiation disease Disease progression Diseases disorder driving dysregulation ectopic expression Effect expression failure fibroblast fibroblasts fibrosis final common pathway foci form found histologic identify idiopathic Invasion investigated IPF kidney led to life liver Liver fibrosis lung Lung diseases Lung fibrosis Lungs mechanism mediator MicroRNAs Migration miRNA miRNA expression miRNAs morbidity morbidity and mortality mouse model Myofibroblast non-coding RNA Organ failure organ function pathogenic pathogenic mechanism pathogenic mechanisms Patient patients performed poor prognosis proliferation promote pulmonary fibrosis reducing response response rate responsible scar scar tissue Signaling significantly increased strain susceptibility targeting TGFβ therapeutic potency therapeutic strategy thought tissue treat ureteral obstruction
[DOI] 10.1371/journal.pgen.1003291 PMC 바로가기 [Article Type] Research Article

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

Clinical Trial

Published on 2010-05-112022-10-06
Journal: Proceedings of the National Academy of Sciences of
[Category] 진단,

[키워드] acquisition Administered Adult Adults Analysis antibody antiviral activity Antiviral effect assays clinical evidence concentrations decrease different double-blind Effectiveness enrolled exhibiting Factors healthy subject Human increase in independent Infected infected children Infection intranasal mechanism mRNA multiple logistic regression murine model nasal nasal washe nucleocapsid number of infected PCR Placebo placebo-controlled study placebo-controlled trial Proinflammatory cytokine proportion Protein protein expression Randomized recipient recipients representing respiratory syncytial virus RNA RSV RSV infection safety profile saline placebo significantly lower siRNA subjects tested therapeutic Therapeutic approach therapy treat uninfected unique viral culture was measured wild-type
[DOI] 10.1073/pnas.0912186107 PMC 바로가기 [Article Type] Clinical Trial

Long-term Psychological and Occupational Effects of Providing Hospital Healthcare during SARS Outbreak

Research

Published on 2006-12-012022-10-31
Journal: Emerging Infectious Diseases
[Category] Coronavirus,

SARS: Systematic Review of Treatment Effects

Research Article

Published on 2006-09-122022-10-29
Journal: PLoS Medicine
[Category] Coronavirus,

[키워드] 2003 active against acute respiratory distress acute respiratory syndrome adverse effect affected antiviral drug ARDS Author be applied Blood carried caused CENTRAL China clinical clinical trial clinician conducted Controlled convalescent plasma Corticosteroids cough criteria Culture database death death rate determine disease dosage drug Effect effective Effectiveness Evidence example Fever finding found group had no Health care help helping HIV/AIDS identify IFN IFN type I immune system immunoglobulins In vitro studies in vitro study include inclusion criteria Inconclusive Inflammation information Intravenous immunoglobulin Laboratory life-threatening Lungs MedlinePlus MONITOR NO occurred outbreak Outbreaks Patient patients patients with SARS Pneumonia Potential treatment Protein protocol real time recommendation reduce reduced reported Research researcher review ribavirin Ritonavir SARS patients SARS-CoV SARS-infected patient SARS-infected patients searched severe sneeze Source specific symptom steroid Steroids Symptom syndrome systematic review the WHO tissue treat Treatment Trial Type I IFN type I interferon viral disease virus viruses Web while WHO Wikipedia World Health Organization
[DOI] 10.1371/journal.pmed.0030343 PMC 바로가기 [Article Type] Research Article

Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants

Research Article

Published on 2006-07-042022-10-29
Journal: PLoS Medicine
[Category] Coronavirus,

[키워드] 2003 acute respiratory syndrome Administered affected against SARS-CoV Alter Amino acid anti-SARS-CoV antibody antibody antibody concentration Antigen antigens approach arising Bacteria binding blocked Blood breadth carried caused center China close contact close person-to-person contact Combination complementary Concentration Control convalescent SARS patient coronavirus Coverage CR3014 CR3022 died different disease disease severity dose Effect effective Epidemic Epidemics epitope escape experiment feasible ferret ferrets finding generate glycoprotein Guangdong Health healthy Hong Kong Human human cell human cells human macrophage Human monoclonal antibody humans immune Immune escape immunization immunize in vitro individual effects Infected infecting Infection infectious Infectious disease information interact Interaction International killing Laboratory less limit lung damage Lung pathology mAb mAbs measure monoclonal monoclonal antibody Mutation neutralization neutralized NO organism Patient pharyngeal Prevent prevented prevention producing Prophylaxis provided quarantine recognize recognizing reduce reduction repeated replicated required Research researcher residue responsible SARS epidemic SARS-CoV SARS-CoV infection screened shown sick Spread strain suppress synergistic synergistic fashion synergy tested the disease the receptor-binding domain Travel treat variant variants viral escape viral spread virus virus Virus neutralization virus strain virus-neutralizing viruses website Wikipedia World Health Organization
[DOI] 10.1371/journal.pmed.0030237 PMC 바로가기 [Article Type] Research Article

Generation of human antibody fragments recognizing distinct epitopes of the nucleocapsid (N) SARS-CoV protein using a phage display approach

Research Article

Published on 2005-09-192022-10-28
Journal: BMC Infectious Diseases
[Category] Coronavirus,

Inhibition of SARS Coronavirus Infection In Vitro with Clinically Approved Antiviral Drugs

Research

Published on 2004-04-012022-10-31
Journal: Emerging Infectious Diseases
[Category] Coronavirus,