Neutralizing Antibody Activity Against the B.1.617.2 (delta) Variant Before and After a Third BNT162b2 Vaccine Dose in Hemodialysis Patients혈액 투석 환자에서 세 번째 BNT162b2 백신 접종 전후의 B.1.617.2(델타) 변이체에 대한 중화 항체 활성Article Published on 2022-03-042022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] activity addition Against Anti-RBD antibodies Anti-RBD antibody B.1.617.2 BNT162b2 correlation COVID-19 COVID-19 vaccination delta variant demonstrated determined by dialysis Epitopes Hemodialysis high risk Humoral immunity IgG IgG antibodies IgG antibody Immune escape Immunity immunocompromised individuals IQR Live virus median neutralization Neutralizing Neutralizing activity Patient SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes second vaccination seroconversion rate seroconverted Seropositivity severe COVID-19 significantly higher the strongest vaccination vaccine dose variant variants variants of concern was performed [DOI] 10.3389/fimmu.2022.840136 PMC 바로가기 [Article Type] Article
Submillisievert CT chest for COVID-19 patients in a rural hospital with limited resourcesResearch Published on 2022-03-042022-10-31 Journal: The Egyptian Journal of Radiology and Nuclear Medicine [Category] COVID-19, [키워드] Analysis approved As low as reasonably achievable (ALARA) both group Chest CT COVID-19 COVID-19 infection COVID-19 patient CT chest CT scan detect dose dose length product hospital IQR likelihood Likert scale Mann–Whitney U test median Nasopharyngeal swab parenchymal Patient performed Probability protocol pulmonary involvement Radiation dose reducing reduction in resource resources Result retrospective sensitivity Sensitivity and specificity Submillisievert the median two-tailed Ultra-low dose CT scan [DOI] 10.1186/s43055-022-00737-9 PMC 바로가기 [Article Type] Research
Assessment of Clinical Effectiveness of BNT162b2 COVID-19 Vaccine in US Adolescents미국 청소년에 대한 BNT162b2 COVID-19 백신의 임상 효과 평가Research Published on 2022-03-032022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 변종, [키워드] 95% CI Adolescent age assessment association asymptomatic infection B.1.617.2 black BNT162b2 BNT162b2 vaccine case-control study caused Chain Reaction clinical Clinical data Clinical symptoms clinical trial conducted Connecticut Control COVID-19 COVID-19 vaccine defined Delta delta variant dose doses effective Effectiveness elapsed estimate exposure female Final finding General population Hispanic Hospitalization hospitalizations immunization immunized Importance Increases increases in Infection IQR logistic regression models matched control measure median age median time medical record medical records negative test New objective Odds ratio of BNT162b2 participant Participants Point positive test result predominant Primary outcome receiving Relevance residence Result retrospective RT-PCR RT-PCR test SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 positivity SARS-CoV-2 test secondary setting single dose symptomatic and asymptomatic symptomatic infection symptomatic infections test result test results tested the SARS-CoV-2 the vaccine Vaccine vaccine dose vaccine doses variant of SARS-CoV-2 white [DOI] 10.1001/jamanetworkopen.2022.0935 PMC 바로가기 [Article Type] Research
Evaluation of a commercial ELISA as alternative to plaque reduction neutralization test to detect neutralizing antibodies against SARS-CoV-2Article Published on 2022-03-032022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] Antibody titer Antibody titers binding convalescent convalescent patient Cutoff detect diagnostic ELISA ELISAs evaluate exhibited FIVE Genscript individual IQR median Neutralizing antibodies neutralizing antibody plaque reduction neutralization population immunity pre-vaccination PRNT required SARS-CoV-2 Sensitivity and specificity serum samples sVNT vaccinated individuals vaccine trial Virology virus neutralization test [DOI] 10.1038/s41598-022-07597-3 PMC 바로가기 [Article Type] Article
Effects of a Lifestyle Intervention to Prevent Deterioration in Glycemic Status Among South Asian Women With Recent Gestational Diabetes A Randomized Clinical TrialResearch Published on 2022-03-022022-10-29 Journal: JAMA Network Open [Category] COVID-19, [키워드] age Analysis analyzed approach Asia baseline body mass index Can clinical Controlled trial COVID-19 COVID-19 pandemic Deterioration diabetes Diagnosis did not reduce Effect effective enrolled excluded exclusion criteria fasting glucose Final finding Follow-up gestational diabete Gestational diabetes glucose tolerance glycemia glycemic hazard ratio hospital impacted Importance IMPROVE increased risk India individuals ineligible Intervention intervention group investigated IQR Local lockdown measure median objective occurred outcome participant Patient physical activity Point Pregnancy Prevent primary analysis Primary outcome proportion Randomized randomized clinical trial recent reducing Registration registry Relevance resources Result secondary secondary outcome setting South South Asian status subsequent survival type 2 diabete type 2 diabetes usual care women worsening [DOI] 10.1001/jamanetworkopen.2022.0773 PMC 바로가기 [Article Type] Research
Mortality and associated risk factors in patients hospitalized due to COVID-19 in a Peruvian reference hospitalResearch Article Published on 2022-03-022022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95%CI Adjusted analysis adjusted hazard ratio Admission age alteration biochemical Clinical characteristics Cohort cohort study Comorbidity Corticosteroid COVID-19 Cox regression model determine dose evaluate Factors general condition hematological high mortality hospital Hospitalization Hospitalized hypertension in-hospital mortality independent variable IQR Ivermectin laboratory result leukocyte lower mortality lower oxygen saturation male median medical record moderate Mortality mortality rate National obesity objective outcomes oxygen saturation patients patients hospitalized patients with COVID-19 Physical examination Result risk factor Sociodemographic Treatment type 2 diabete use of corticosteroid use of hydroxychloroquine was used [DOI] 10.1371/journal.pone.0264789 PMC 바로가기 [Article Type] Research Article
Effect of the third dose of BNT162b2 vaccine on quantitative SARS-CoV-2 spike 1–2 IgG antibody titers in healthcare personnelResearch Article Published on 2022-03-022022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] administration adverse event Antibody titer Antibody titers applied arthralgia BNT162b2 BNT162b2 vaccine booster booster dose caused Cohort decrease dose Effect fatigue female Fever healthcare personnel healthcare worker IgG antibody titer IgG antibody titers immunization increase in injection IQR Local longitudinal cohort study material Mild myalgia of BNT162b2 Pain participant positive proportion protocol Quantitative regimen Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike second dose severity specific symptom the median Vaccine Vaccines [DOI] 10.1371/journal.pone.0263942 PMC 바로가기 [Article Type] Research Article
Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial중등도 COVID-19 감염으로 입원한 환자를 위한 글리시리진 및 보스웰산 병용 치료: 무작위 임상 시험Randomized Controlled Trial Published on 2022-03-012022-09-10 Journal: Inflammopharmacology [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] Advancing Adverse adverse events age Anti-inflammatory Antiviral assigned Boswellic aids clinical clinical status Clinical status score Combination combination treatment COVID-19 death diagnosed double-blind drugs Efficacy eligibility eligible Enrollment evaluated event Evidence FIVE glycyrrhizin hospital hospitalized patient hospitalized patients Identifier immunomodulating Infection institutional protocol IQR matching placebo median median age Mild mild to moderate moderate Moderate COVID-19 moderate infection moderate symptoms Mortality mortality rate outcome Patient PCR test Placebo placebo group placebo-controlled Primary outcome Randomized randomized clinical trial randomized trial Randomly receive receiving recent Recovery time Registered required Safe SARS-CoV-2 secondary secondary outcome significant decrease significant difference significantly shorter single-center small sample size study drug Symptoms the placebo group therapeutic Time to recovery Treatment treatment of COVID-19 Trial university variant variants [DOI] 10.1007/s10787-022-00939-7 PMC 바로가기 [Article Type] Randomized Controlled Trial
A sigh of relief: vaccine-associated hypermetabolic lymphadenopathy following the third COVID-19 vaccine dose is short in duration and uncommonly interferes with the interpretation of [ 18 F]FDG PET-CT studies performed in oncologic patients안도의 한숨: 세 번째 COVID-19 백신 접종 후 백신 관련 대사과다 림프절병증은 지속 기간이 짧고 드물게 종양 환자에서 수행된 [ 18 F]FDG PET-CT 연구의 해석을 방해합니다Article Published on 2022-03-012022-09-11 Journal: European Journal of Nuclear Medicine and Molecular [Category] SARS, 치료기술, [키워드] administration age BMI BNT162b2 BNT162b2 vaccine correlation COVID-19 COVID-19 vaccine dose dose administration doses GRADE High-grade Humoral immunity immune response incidence incidence of COVID-19 independent predictor independent predictors interfere Interpretation IQR less Lymphadenopathy median time multivariable logistic regression obese obese patients Older Oncologic imaging Patient patients performed PET-CT reported separation time interval unlikely vaccination vaccine dose were recorded [DOI] 10.1007/s00259-021-05579-7 PMC 바로가기 [Article Type] Article
Physiotherapy-assisted prone or modified prone positioning in ward-based patients with COVID-19: a retrospective cohort studyObservational Study Published on 2022-03-012022-10-05 Journal: Physiotherapy [Category] SARS, 임상, [키워드] 95%CI Acute respiratory failure age clinical COVID-19 Desaturation evaluate feasibility feasible Health hospital Hypoxemia improvements in oxygenation Intervention IQR mean difference measure median Observational cohort study occurred outcome oxygen oxygen flow rate Oxygen requirement Oxygenation participated Patient patients Physical therapy Physical therapy modalities prone prone positioning required Research resolved retrospective cohort study scale SpO2 therapy utilised ward-based patient with COVID-19 [DOI] 10.1016/j.physio.2021.09.001 PMC 바로가기 [Article Type] Observational Study