Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19COVID-19에 대해 DNA 나노백신을 보호하고 전달하는 분리형 마이크로니들 패치Article Published on 2021-09-282022-09-11 Journal: ACS Nano [Category] SARS, 치료법, [키워드] adaptive Adaptive immunity administration Against coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine decrease decreases DNA DNA vaccine DNA vaccines feature IFN-γ IgG IL-2 immune immune adjuvant Immune cell immune cells immune responses Immunity immunization in vivo Intramuscular injection lymph nodes Microneedle nucleic acid nucleic acid vaccine nucleocapsid pandemic patch Polymer Protein room temperature separable microneedle. significantly increased storage T cell T cells temperature tissue treated vaccination Vaccine Vaccines virus [DOI] 10.1021/acsnano.1c03252 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolismSARS-COV-2 감염은 B- 세포 대사를 강화함으로써 B 세포에서 CD19 발현을 하향 조절함으로써 회수 된 환자에서 면역 결핍을 유발한다.Article Published on 2021-09-222022-08-31 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 진단, [키워드] Adaptive immunity B cell B cells B-cell B-cell response BCR cause caused CD19 cell metabolism changed characterized COVID-19 downregulating dysregulation expression frequencies Frequency healthy control healthy controls immune Immune phenotype immune regulation immunodeficiency Immunological disorders Intervention memory B cell memory B cells metabolism Patient Population Recovered COVID-19 patients recovered patient recovered patients reduced SARS-COV-2 infection Signaling significantly significantly increased Stimulation subset [DOI] 10.1038/s41392-021-00749-3 PMC 바로가기 [Article Type] Article
CD8 + PD-L1 + CXCR3 + polyfunctional T cell abundances are associated with survival in critical SARS-CoV-2–infected patientsCD8 + PD-L1 + CXCR3 + 다항식 T 세포 풍부도는 중요한 SARS-COV-2에 감염된 환자의 생존과 관련이 있습니다.Research Article Published on 2021-09-222022-08-31 Journal: JCI Insight [Category] SARS, 바이오마커, 치료법, [키워드] adaptive Adaptive immunity CD4 CD8 Cell circulating control mechanisms COVID-19 Critical CXCR3 CXCR5 Cytometry death Deceased determine effector memory effector T cell effector T cells fatal disease Frequency functional granzyme B HLA-DR Imbalance immunology Increased Infectious disease intensive care involved life-threatening mechanism memory T cell memory T cells outcome patients patients with COVID-19 PD-L1 perforin phenotype phenotypic Population Principal component principal component analysis proportion proportions provide SARS-CoV-2–infected patient separation Stage stem cell survival T cell T cell response T cells Teff Vaccine design Viral viral control viral infection [DOI] 10.1172/jci.insight.151571 PMC 바로가기 [Article Type] Research Article
Serological assessment of SARS-CoV-2 infection during the first wave of the pandemic in Louisville Kentucky루이빌 켄터키에서 유행병의 첫 번째 물결 동안 SARS-COV-2 감염의 혈청 학적 평가Article Published on 2021-09-142022-09-01 Journal: Scientific Reports [Category] SARS, 진단, 치료법, [키워드] Adaptive immunity Analysis Antibody responses Antibody titer Biotechnology Characteristics defined Diagnosis Diseases ELISA enzyme enzyme-linked immunosorbent assay First wave healthcare worker Healthcare workers Humoral immunity IgA IgA antibodies IgA antibody IgG IgM response IgM responses immune response immunology individual Infection Infectious diseases lack Local microneutralization neutralization neutralization assays neutralize nucleocapsid pandemic performance plaque positive correlation Protective Protective antibody Proteins RBD Receptor binding domain SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 pandemic Sensitivity and specificity serological assays seropositive spike the antibody response the SARS-CoV-2 vaccination was used [DOI] 10.1038/s41598-021-97423-z PMC 바로가기 [Article Type] Article
Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 PatientsReview Published on 2021-09-092022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] accelerate accompanied Adaptive immune response Adaptive immunity age aging antioxidant antioxidants antiviral activity antiviral immunity Asymptomatic Comorbidities coronavirus disease COVID-19 COVID-19 symptom Cytokine storm deficiency dendritic cell determinant disease distress dysregulation Elderly patient Healthcare system heterogeneous Illness severity immune function Immunosuppression Infection Inflammation Inflammatory inflammatory immune response inhibiting viral replication Innate immunity interferon Macrophage Mild molecular mechanism outcomes oxidative oxidative stress pandemic pathophysiological progression response resulting resveratrol risk SARS-CoV-2 SARS-COV-2 infection Sex Symptoms the patient Treatment viral infections [DOI] 10.3390/antiox10091440 PMC 바로가기 [Article Type] Review
Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents무증상 또는 경증의 증상이 있는 SARS-CoV-2 감염은 소아 및 청소년에서 지속적인 중화 항체 반응을 유발합니다Research Article Published on 2021-09-082022-09-10 Journal: JCI Insight [Category] SARS, 진단, 치료기술, [키워드] acute infection Adaptive immunity All participants Antibody Response Antibody responses Asymptomatic children comparable contribute detectable elicit evaluated generate humoral immune response humoral immune responses IgA IgG IgM immune response immune responses immunology Infectious disease Mild Neutralizing activity Neutralizing antibody response Participants populations question Reinfection robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection sera Spread strength symptomatic infection symptomatic SARS-CoV-2 infection virus-neutralizing [DOI] 10.1172/jci.insight.150909 PMC 바로가기 [Article Type] Research Article
Adaptive immune responses to SARS-CoV-2 in recovered severe COVID-19 patients회복된 중증 COVID-19 환자의 SARS-CoV-2에 대한 적응 면역 반응Article Published on 2021-09-012022-09-11 Journal: Journal of Clinical Virology [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] 95% CI adaptive Adaptive immunity adjusted age bilateral pneumonia binding CD4 CD69 CD8 Clinical diagnosis clinical form Cohort Comorbidities Comorbidity concurrent COVID-19 detectable determine ELISA flow cytometry form Hospitalization Hospitalized ICS IFNγ IgG IgG antibodies IgG antibody IgGs immune response Immunity imperative in some increased the risk indicated M protein male median median age onset of symptom Patient patients Pneumonia RBD-specific IgG receptor Receptor binding domain Receptor binding domain-specific IgG antibodies recruited SARS-CoV-2 SARS-CoV-2 RBD serum IgG Serum level serum levels severe COVID-19 patient severe forms of COVID-19 Sex significantly specific IgG antibodies subject symptoms onset T cell T cells T-cell Response T-cell responses undetectable were measured Whole blood [DOI] 10.1016/j.jcv.2021.104943 PMC 바로가기 [Article Type] Article
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection급성 SARS-CoV-2 감염 시 뚜렷한 전신 및 점막 면역 반응Comparative Study Published on 2021-09-012022-09-12 Journal: Nature Immunology [Category] MERS, SARS, 바이오마커, 임상, 진단, 치료기술, 치료법, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute SARS-CoV-2 infection Adaptive immunity Analysis antibodies Bacteria bacterial communities Bacterial community clinical outcomes clinically Cohort coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 cytokine Cytokines Defense determine elevated highlight Humoral response immune response immune responses Immunity implicated Infection Inflammation Inflammatory cytokines interferon Local microbial Microbiome mucosal mucosal immune Mucosal immunology mucosal surfaces nasopharyngeal Nasopharyngeal swab nasopharyngeal viral load Neutralizing antibodies Paired analysis Pathogenic microorganisms Pathologies pathology patients with COVID-19 performed plasma sample plasma samples Potential PROTECT Protective respiratory infections respiratory tract response responses SARS-CoV-2 SARS-CoV-2 spike-specific SARS-CoV-2-infected patient SARS-CoV-2-infected patients secondary respiratory infections severe acute respiratory syndrome Coronavirus severe COVID-19 specific antibodies systemic immune response systemic inflammatory tissue viral infection Viral load [DOI] 10.1038/s41590-021-01028-7 PMC 바로가기 [Article Type] Comparative Study
Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8 + T Cells during Convalescence회복기 동안 수명이 긴 SARS-CoV-2-특이적 CD8 + T 세포의 장기간 조정된 분화Article Published on 2021-09-012022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] SARS, 변종, 치료법, [키워드] accompanied Activation adaptive Adaptive immunity CD4 CD8 characteristic conducted conserved convalescence convalescent coordination COVID-19 Cytometry decrease differentiation flight homeostatic human donor Immunity immunodominant increase in memory Mild Nuc nucleocapsid over participant peptide proliferation recognizing reported residue residues SARS-CoV-2 screened serological measurements Spike proteins T cell T cells tetramer variants of concern [DOI] 10.4049/jimmunol.2100465 PMC 바로가기 [Article Type] Article
Trans-ethnic genome-wide association study of severe COVID-19중증 COVID-19에 대한 인종 간 게놈 전체 연관성 연구Article Published on 2021-08-312022-09-10 Journal: Communications Biology [Category] MERS, 바이오마커, 변종, 유전자 메커니즘, 임상, 치료기술, [키워드] ABO adaptive adaptive immune system Adaptive immunity allele frequencies allele frequency Blood Group blood group system caused Chinese clinical development Clinical symptoms contributing to Control controls COVID-19 COVID-19 Host Genetics Initiative COVID-19 severity European followed by FOXP4 FOXP4-AS1 frameshift Genetic variant genome-wide association Genome-wide association studies Genome-wide association study genotyped highlight Hospitalized identify Immunity individuals Infection initiative insertion intronic variant loci MEF2B Meta-analysis Mild Odds ratio Patient rs8176719 sequenced Severe case severe COVID-19 severe disease Symptoms tested viral infection [DOI] 10.1038/s42003-021-02549-5 PMC 바로가기 [Article Type] Article