A Model Predicting Mortality of Hospitalized Covid-19 Patients Four Days After Admission: Development, Internal and Temporal-External Validation입원 4일 후 입원한 Covid-19 환자의 사망률을 예측하는 모델: 개발, 내부 및 시간-외부 검증Cellular and Infection Microbiology Published on 2022-01-242022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, [키워드] Admission age Alpha Alpha variant AUROC B.1.1.7 blood parameter C-reactive protein calibration slope Care characteristic clinical coronavirus COVID-19 creatinine cross Day develop development discharge explained Fever Final FIVE haematological parameter haematological parameters Health Health care Health care system Hospitalized hospitalized COVID-19 patients hospitalized patients hospitals Identifier in-hospital mortality internal Lactate lactate dehydrogenase linear mixed model Logistic regression Model Mortality mutations non-survivor Non-survivors objective Occurrence on admission parameter Patient Platelet Platelet count Prediction model prevalent prognostic model receiver operating characteristic receiver operating characteristic curve reduce Registration Result slope Support supported survival survivor validation variable variable selection variables Variation was done [DOI] 10.3389/fcimb.2021.795026 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Is the Alpha Variant of SARS-CoV-2 Associated with a Higher Viral Load than the Historical Strain in Saliva Samples in Patients with Mild to Moderate Symptoms?Article Published on 2022-01-212022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] Acute respiratory infection Alpha variant Analysis collected COVID-19 COVID-19 pandemic Evolution Follow-up load Mild moderate no significant difference observé onset of symptom Patient performed positive primary care Saliva salivary Sample SARS-CoV-2 SARS-CoV-2 strains strain Strains Symptoms the SARS-CoV-2 Transmissibility used data variant Viral load [DOI] 10.3390/life12020163 PMC 바로가기 [Article Type] Article
Local Emergence of a del HV69-70 SARS-CoV-2 Variant in Burgundy, FranceBrief Report Published on 2022-01-202022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Affect Alpha variant Deletion deletion variant elderly emergence Epidemic France in some nursing home outbreak Outbreaks public health risk SARS-CoV-2 short-lived spike gene Spread Vaccine development variant [DOI] 10.3390/pathogens11020124 PMC 바로가기 [Article Type] Brief Report
Measuring infectious SARS-CoV-2 in clinical samples reveals a higher viral titer:RNA ratio for Delta and Epsilon vs. Alpha variants임상 샘플에서 감염성 SARS-CoV-2를 측정하면 Delta 및 Epsilon 대 Alpha 변이체에 대해 더 높은 바이러스 역가:RNA 비율이 나타납니다.423 Published on 2022-01-202022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Alpha Alpha variant clinical sample clinical samples collected competent coronavirus COVID-19 pandemic Delta delta variant E gene Epsilon explain increase in individual Infectious virus Infectivity Live virus measure novel Prevent Previous studies previous study processed quantity Replication reported respiratory reveal RNA RT-PCR SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus significantly higher Spread swab kit variant variants Variation Viral viral genome Viral load Viral RNA viral titer viral titers Viral transmission virus [DOI] 10.1073/pnas.2116518119 PMC 바로가기 [Article Type] 423
Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitroPharmacology Published on 2022-01-192022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activity Against Alpha Alpha variant antidepressant antidepressants (AD) antipsychotic antipsychotic drug antiviral action B.1 B.1 lineage B.1.1.7 B.1.351 B.1.617.2 Beta variant Calu-1 Cell Cell culture Clinical practice clinical study clinically Compound consequence COVID-19 delta variant derivative doses drug E484K Effect effective embryonic kidney cell epithelial cell line expand First wave Fluoxetine human lung in vitro Infection information inhibited inhibitor investigated K417N Lineage mutations N501Y novel performed primary mechanism Pseudotyped virus pseudovirus pseudoviruses Receptor binding domain remained repurposing Rolipram SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike show tested these compound variants variants of concern variants of SARS-CoV-2 viability [DOI] 10.3389/fphar.2021.755600 PMC 바로가기 [Article Type] Pharmacology
Immunogenicity of SCB-2019 Coronavirus Disease 2019 Vaccine Compared With 4 Approved Vaccines4개의 승인된 백신과 비교한 SCB-2019 코로나바이러스 질병 2019 백신의 면역원성Comparative Study Published on 2022-01-182022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Alpha variant alum antibody approved authorization binding antibody comparable comparison coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 Efficacy elicited immune response immunogenicity Laboratory predicted reported respiratory response responses against SARS-CoV-2 SCB-2019 shown Spike protein Trial Vaccine vaccine efficacy Vaccines variants variants of concern [DOI] 10.1093/infdis/jiab574 PMC 바로가기 [Article Type] Comparative Study
Early-stage spatial disease surveillance of novel SARS-CoV-2 variants of concern in Germany with crowdsourced data크라우드 소싱 데이터를 사용하여 독일에서 우려되는 새로운 SARS-CoV-2 변종에 대한 초기 단계 공간 질병 감시Article Published on 2022-01-182022-09-10 Journal: Scientific Reports [Category] SARS, 변종, [키워드] Alpha Alpha variant association coronavirus COVID-19 Disease surveillance Effect epidemiological Epidemiology estimate evaluate Evidence Germany Hospitalization incidence rate International Local new virus outbreak over produced public health Region reported sampling errors SARS-CoV-2 variant sensitivity significant increase Spread statistical Statistics These data variants of concern viral infection VoC [DOI] 10.1038/s41598-021-04573-1 PMC 바로가기 [Article Type] Article
The impact of hospital attendance on COVID-19 infection in cancer patients: an assessment of data from Guy’s Cancer암 환자의 COVID-19 감염에 대한 병원 출석의 영향: Guy's Cancer의 데이터 평가Research Article Published on 2022-01-172022-09-10 Journal: Future Oncology [Category] MERS, SARS, 변종, [키워드] Abstract age Alpha Alpha variant Analysis approved Asymptomatic Asymptomatic COVID-19 Cancer cancer patient Cancer patients cancer treatment Care Clinical data collected COVID COVID-19 COVID-19 infection database demographic data driven by England epicenter Factor Follow-up greater transmissibility hospital in some increased risk Infection information Logistic regression Odds ratio Patient patient population positive predominant raised reduced Research risk of transmission SARS-CoV-2 test second wave Testing the disease the patient Treatment variant vulnerable population was used Welfare [DOI] 10.2217/fon-2021-1329 PMC 바로가기 [Article Type] Research Article
Detection of SARS-CoV-2 RNA in Bivalve Mollusks by Droplet Digital RT-PCR (dd RT-PCR)Droplet Digital RT-PCR(dd RT-PCR)에 의한 이매패류 연체동물의 SARS-CoV-2 RNA 검출Article Published on 2022-01-142022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 변종, 치료기술, [키워드] Alpha Alpha variant approach assays B.1.1.7 bivalve Campania characteristic collected Concentration COVID-19 detectable detection Digital displaying droplet feces FIVE human pathogen impacted infected patient infected patients Lineage Lineage B.1.1.7 median Mollusk MONITOR Mutation nsp14 outbreak Partial Pathogens PCR positive sample Prevalence real-time RT-PCR RT-PCR SARS-CoV-2 SARS-CoV-2 RNA Sequencing shellfish tested variant Viral virus was obtained wastewater water water bodies water body waters [DOI] 10.3390/ijerph19020943 PMC 바로가기 [Article Type] Article
Discriminatory Weight of SNPs in Spike SARS-CoV-2 Variants: A Technically Rapid, Unambiguous, and Bioinformatically Validated Laboratory ApproachArticle Published on 2022-01-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Alpha variant analyses Analysis assigned assumed Beta bioinformatic validation COVID-19 COVID-19 pandemic COVID-19 variants demonstrated Gamma greater identify Lineage Mutation mutations N gene N501Y PCR Rapid Reactions reliability S gene Sanger sequencing SARS-CoV-2 SARS-CoV-2 virus selected SNP spike Spread statistical unique variant variants weight whole-genome sequencing [DOI] 10.3390/v14010123 PMC 바로가기 [Article Type] Article