Evaluation of favipiravir in the treatment of COVID-19 based on the real-worldMeta-Analysis Published on 2021-12-222023-07-01 Journal: Expert review of anti-infective therapy [Category] COVID19(2023년), SARS, [키워드] Antiviral agents COVID-19 Favipiravir Meta-analysis viral clearance [DOI] 10.1080/14787210.2022.2012155 PMC 바로가기 [Article Type] Meta-Analysis
RNA-Based COVID-19 vaccine candidates with clinical phase trials in progressRNA 기반 COVID-19 백신 후보, 임상 단계 진행 중Review Published on 2021-12-172022-09-10 Journal: Turkish Journal of Medical Sciences [Category] SARS, 임상, [키워드] Affect antiviral agent Antiviral agents candidate Course COVID-19 COVID-19 infection COVID-19 vaccine Critical death disease effective expected global pandemic Google Scholar Health Organization herd immunity Immunity immunized increase m-RNA mutate pandemic plan RNA SARS-CoV2 seriousness situation Society the disease the vaccine the WHO Topic Treatment Trial trials urgency vaccination Vaccine vaccine candidates vaccine trials Vaccines virus WHO World Health Organization [DOI] 10.3906/sag-2104-139 PMC 바로가기 [Article Type] Review
Indomethacin-based PROTACs as pan-coronavirus antiviral agents범 코로나바이러스 항바이러스제로서의 인도메타신 기반 PROTACArticle Published on 2021-12-152022-09-11 Journal: European journal of medicinal chemistry [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition anti-inflammatory drug Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral agent Antiviral agents antiviral potency Chimera class coronavirus Coronavirus-2 CoVs demonstrated develop early stage example host protein human CoVs indicated indomethacin infected Vero E6 cells inhibit inhibit SARS-CoV-2 interact knowledge mechanism mechanism of action Nsp7 PGES-2 prostaglandin prostaglandin E PROTAC Protein proteolysis proteomic study Replication reported SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 strains Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Support synthesis targeting the SARS-CoV-2 Vero E6 VERO E6 cells [DOI] 10.1016/j.ejmech.2021.113814 PMC 바로가기 [Article Type] Article
Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus중증 급성 호흡기 증후군 코로나바이러스 2 및 에볼라 바이러스에 대한 렘데시비르의 지방 아실 접합체의 합성 및 항바이러스 활성Article Published on 2021-12-152022-09-11 Journal: European journal of medicinal chemistry [Category] SARS, 신약개발, 치료제, [키워드] A significant reduction acute respiratory syndrome antiviral activities antiviral activity antiviral agent Antiviral agents Calu3 CaLu3 cells characterization comparable Compound conjugate Conjugates coronavirus derivative derivatives Ebola Ebola virus EBOV Effectiveness exhibited fatty Fatty acid fatty acids Fatty acyl-RDV conjugates half-life Human plasma IMPROVE in viral in vitro less mono physical purification RDV reduction in remained Remdesivir Replication RNA synthesis SAR SAR-CoV-2 SARS-CoV-2 selected shown Structure-activity relationships (SAR). synthesis these compound these compounds Transcription VeroE6 cells Viral RNA viral RNA synthesis [DOI] 10.1016/j.ejmech.2021.113862 PMC 바로가기 [Article Type] Article
Inhibition of the RNA-dependent RNA Polymerase of the SARS-CoV-2 by Short Peptide Inhibitors짧은 펩티드 억제제에 의한 SARS-CoV-2의 RNA 의존성 RNA 중합효소 억제Article Published on 2021-12-012022-09-11 Journal: European journal of pharmaceutical sciences : offi [Category] SARS, 치료제, [키워드] activities activity antiviral agent Antiviral agents approach Arg2 binding site comparison complexes COVID-19 COVID-19 patient detrimental docking Docking studies drug drugs early recovery help inhibiting inhibition inhibitor inhibitors insertion insertion site molecular docking NTP nucleotide nucleotides patients peptide Peptide inhibitor Peptide Inhibitors peptides proliferation RdRP Remdesivir Replication RNA RNA-dependent RNA polymerase SARS-CoV-2 synthesis the SARS-CoV-2 viral genome Viral load viral loads [DOI] 10.1016/j.ejps.2021.106012 PMC 바로가기 [Article Type] Article
Discovery of SARS-CoV-2 Nsp14 and Nsp16 Methyltransferase Inhibitors by High-Throughput Virtual ScreeningArticle Published on 2021-11-302022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] acute respiratory syndrome analogue Antiviral agents antiviral drugs Cell Compound coronavirus cytotoxic effects docking energy transfer Enzymes evade evaluated fluorescent glycine High-throughput virtual screening homogeneous HTRF Human immune system inhibition activity inhibitor inhibitors majority methyltransferase mRNA MTase inhibitors nsp14 nsp16 performed S-adenosylmethionine SAM SARS-CoV-2 Screening Seven starting point target tested the SARS-CoV-2 Virtual screening [DOI] 10.3390/ph14121243 PMC 바로가기 [Article Type] Article
Consecutive Hits of COVID-19 in India: The Mystery of Plummeting Cases and Current Scenario인도의 COVID-19 연속 히트: 급락 사례의 미스터리 및 현재 시나리오Review Published on 2021-11-302022-09-11 Journal: Archives of Razi Institute [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affecting Antiviral agents approved bat bats challenges Chinese city Collaborative effort confirmed case coronavirus disease Coronavirus disease 2019 Coronavirus-2 country COVID-19 COVID-19 case COVID-19 cases COVID-19 outbreak COVID-appropriate behavior current death deaths drug Emergency use evidence of fear Fears of third wave healthcare hospital Human India Novel coronavirus novel coronavirus disease oxygen pandemic Pandemic scenario pangolins SARS-CoV-2 scarcity scenario second second wave Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus situation Spread Stress Surveillance Transmissibility Transmission vaccination Vaccine variants virulence virus virus variant virus variants world population worsened Wuhan [DOI] 10.22092/ari.2021.356147.1791 PMC 바로가기 [Article Type] Review
Broad-Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available, Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside (GS-441524)Article Published on 2021-11-242023-07-02 Journal: Microbiology Spectrum [Category] SARS, [키워드] Antiviral agents Ebola virus Filovirus GS-441524 GS-5734 Hemorrhagic fever virus henipavirus HSAEC1-KT HUH7 cells human small airway epithelial cells human telomerase reverse-transcriptase (hTERT)-immortalized microvascular endothelial cells (TIME) lipid prodrugs NCI-H358 cells Nipah virus ODBG ODBG-P-RVn paramyxovirus Remdesivir remdesivir nucleoside respiratory viruses SARS-CoV-2 VERO E6 cells [DOI] 10.1128/Spectrum.01537-21 PMC 바로가기
A Genetic Trap in Yeast for Inhibitors of SARS-CoV-2 Main ProteaseMethods and Protocols Published on 2021-11-232022-10-29 Journal: mSystems [Category] COVID-19, [키워드] absence Antiviral antiviral agent Antiviral agents antiviral drug blocked candidate Cell cells cellular cleavage cleavage site Compound COVID-19 COVID-19 pandemic detect drug candidate drug target effective ENhance Escherichia coli fluorescent genetic engineering genetic selection system growth IMPROVE in vivo Infection inhibited inhibiting inhibitor inhibitors insertion linker live cell marker MazF toxin Modification mutant other proteases peptide platform Positive selection protease Protease inhibitor Protein required resulting robust Saccharomyces cerevisiae SARS-CoV-2 small molecule small molecule inhibitor Small molecules Specificities Symptoms the SARS-CoV-2 vaccination variant viral replication yeast yeast cell yeast cells [DOI] 10.1128/mSystems.01087-21 PMC 바로가기 [Article Type] Methods and Protocols
Metallodrug Profiling against SARS‐CoV‐2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain‐like Protease PL proFull Paper Published on 2021-11-232022-10-31 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] COVID-19, SARS, [키워드] ACE2 receptor acute respiratory syndrome addition Antiviral Antiviral agents Antiviral effect antiviral therapeutics approved complex complexes Compound compound screening coronavirus drug design Drug discovery evaluated Evidence gold, metallodrugs infected cell inhibitor Interaction ligands mechanisms metal NHC PLpro polyoxometalates potent Profiling protease Protein Replication SARS-CoV-2 SARS‐CoV‐2 selected silver Spike protein Spread starting point target tested the spike protein titanocene [DOI] 10.1002/chem.202103258 PMC 바로가기 [Article Type] Full Paper