Distinct Antibody Responses to Endemic Coronaviruses Pre- and Post-SARS-CoV-2 Infection in Kenyan Infants and Mothers케냐 유아와 산모의 SARS-CoV-2 감염 전 및 후 풍토성 코로나바이러스에 대한 독특한 항체 반응Article Published on 2022-07-122022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] alphacoronavirus antibody Antibody binding association Betacoronavirus boosting cause Cohort coronavirus COVID-19 cross-react cross-reactive cross-reactive antibody cross-reactivity Endemic endemic human coronavirus Evidence HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 highly pathogenic IgG IgG antibody titer Infant Infants Kenya lack levels of antibody memory response mother mothers. response risk SARS-CoV-1 SARS-CoV-1 infection SARS-CoV-2 SARS-CoV-2 antibodies SARS-COV-2 infection Seroconversion unlikely women [DOI] 10.3390/v14071517 PMC 바로가기 [Article Type] Article
Exploring the Immunomodulatory Aspect of Mesenchymal Stem Cells for Treatment of Severe Coronavirus Disease 19중증 코로나바이러스 질환 치료를 위한 중간엽 줄기세포의 면역조절 측면 탐색 19Review Published on 2022-07-122022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 치료법, [키워드] ACE-2 acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 administration affected Alpha alveolar epithelial cell alveolar epithelial cells angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-apoptotic Anti-inflammatory anti-oxidative aspect Asymptomatic average Betacoronavirus breathlessness cause cellular characterized chemokines chest pain Clinical outcome Clinical symptoms colony-stimulating factor coronavirus 2 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients curative cytokine Cytokine storm Cytokine storms damaged dependent on Deterioration disease severity dry cough Effectiveness Effects elicited endothelial engage enzyme epithelial cells excessive inflammation family Coronaviridae fatigue Fever fibroblast fibroblast growth factor functional GCSF genus genus Betacoronavirus granulocyte granulocyte colony-stimulating factor growth factor Growth factors Health healthy histological IL-6 IL-7 IL-8 IL-9 immune cells immune response immune responses immunomodulation immunomodulatory immunomodulatory capabilities immunomodulatory capability Incubation period individual infected individual infected individuals infiltrating immune cells Inflammatory Inflammatory cytokines inflammatory protein inhalation Injury Intention interferon interleukin intravenous intravenous infusion Invasion IP10 lung Lungs Macrophage majority MCP1 Mesenchymal stem cells MIP1A mitigate monocyte monocyte chemotactic protein-1 MSC MSCs multitude myriad Necrosis organ PDGFB persistence Platelet platelet-derived growth factor positioned positive Protein receptor reduce respiratory Respiratory droplets RNA SARS-CoV-2 SARS-COV-2 infection secretion Secretome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sore throat STEM stem cell stem cells subunit supportive therapy symptomatic therapeutic therapy tissue TNF-α translational transmitted Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha undergo Vascular virus widespread [DOI] 10.3390/cells11142175 PMC 바로가기 [Article Type] Review
Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children상기도 유전자 발현은 소아에서 SARS-CoV-2에 대한 보다 강력한 적응 면역 반응을 보여줍니다Article Published on 2022-07-082022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] activated Adaptive immune response airway B cell B cells cause cell type children ciliated cells contribute decrease disease elicit Gene Expression greater groups IFNγ IL-2 IL-4 immune response Infection interferon-stimulated gene interferon-stimulated genes macrophages nasopharyngeal Older Other respiratory viruses pathway Pathways Proinflammatory cytokine proinflammatory cytokine signaling proportion proportions recruitment respiratory viruses robust SARS-CoV-2 SARS-COV-2 infection severe disease T cell T cell activation target TNF upper airway upregulation virus [DOI] 10.1038/s41467-022-31600-0 PMC 바로가기 [Article Type] Article
Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera쥐 감염 및 인간 면역 혈청 탈출에 중요한 SARS-CoV-2 스파이크 돌연변이의 특성화Article Published on 2022-07-072022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] (alpha ACE-2 Alpha angiotensin angiotensin converting enzyme B.1.1.529 B.1.1.7 B.1.351 Beta cause characterization convalescent disease Efficiency enzyme Gamma genetic background H655Y immune infect Infection insertion Lineage lineages lung mice Mild Mild disease morbidity murine Mutation N genes N501Y neutralization not affect obese omicron Omicron variants P.1 post vaccination receptor Receptor binding domain S gene S protein SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 Spike mutation SARS-CoV-2 variant SARS-CoV-2 variants sera Transmissibility USA-WA1/2020 variants virus viruses VOCs wild type [DOI] 10.1038/s41467-022-30763-0 PMC 바로가기 [Article Type] Article
Nasopharyngeal Bacterial Microbiota Composition and SARS-CoV-2 IgG Antibody Maintenance in Asymptomatic/Paucisymptomatic Subjects무증상/무증상 피험자의 비인두 세균성 미생물총 구성 및 SARS-CoV-2 IgG 항체 유지 관리Article Published on 2022-07-062022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response Analysis anti-RBD antibody Asymptomatic Asymptomatic carriers Bacterial best cause characterized condition coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 enrolment Evidence IgG antibody immune response immunoglobulins Immunological memory Infection influence investigated knowledge Lung injury maintenance mechanism microbiota multi-organ failure nasopharyngeal nasopharyngeal bacterial microbiota. Nasopharyngeal swab Odds ratio performed positive positive serology predict Regulation respiratory respiratory infection respiratory infections SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 infections SARS-CoV-2 RNA serum severe acute respiratory syndrome Coronavirus severity subject tested UNICORN Viral viral entry viral infections [DOI] 10.3389/fcimb.2022.882302 PMC 바로가기 [Article Type] Article
Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic micehACE2 형질전환 마우스에서 SARS-CoV-2 감염 후 시간적 뇌 병변Article Published on 2022-07-012022-09-11 Journal: Veterinary pathology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis animal model astrogliosis Beta Brain cause Central nervous system Cerebellum characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 develop different time points distribution Encephalitis hACE2 hACE2-transgenic mice histopathological immunohistochemistry immunolabeling inoculation lesion meningoencephalitis mice mucosa necropsies necropsy Neuroinflammation Neurological disease neuronal neurons Neuropathology nonsuppurative olfactory other organ other organs panel of antibodies panel of antibody performed post inoculation processed question reached Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 lineage SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spongiosis Spread susceptible thrombosis transgenic mice vacuolar vacuolar degeneration variants Vasculitis virological assay virological assays virus [DOI] 10.1177/03009858211066841 PMC 바로가기 [Article Type] Article
The Karolinska NeuroCOVID study protocol: Neurocognitive impairment, biomarkers and advanced imaging in critical care survivorsKarolinska NeuroCOVID 연구 프로토콜: 중환자 생존자의 신경인지 장애, 바이오마커 및 고급 영상Article Published on 2022-07-012022-09-11 Journal: Acta Anaesthesiologica Scandinavica [Category] MERS, 바이오마커, 진단, [키워드] Activation assessment Biomarker Biomarkers Brain brain injury brain MRI Care cause causes cellular cerebrospinal cerebrospinal fluid change Coagulopathy cognitive consequence COVID-19 COVID-19 pandemic Critical Critical care degeneration discharge disease exhibiting expressed fatigue finding Follow-up functional Health health-care system ICU identify immune impairment individual Inflammation Intervention magnetic resonance imaging marker Mental molecular MRI myriad neurocognitive neurocognitive disorders neurodegenerative neurological Neurological deficit neurological deficits neuronal outcome pathological mechanism Patient patient outcome assessment. patients treated performed plan plasma rehabilitation serum severe COVID-19 survivor Survivors Symptom target targets two patients [DOI] 10.1111/aas.14062 PMC 바로가기 [Article Type] Article
SARS-CoV-2 variants and the global pandemic challenged by vaccine uptake during the emergence of the Delta variant: A national survey seeking vaccine hesitancy causesSARS-CoV-2 변종과 Delta 변종 출현 중 백신 섭취로 도전받는 세계적 대유행: 백신 주저성을 찾는 전국 조사Article Published on 2022-07-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis cause children collected conducted contribute COVID-19 COVID-19 infection COVID-19 vaccination COVID-19 vaccine COVID-19 vaccine hesitancy COVID-19 vaccine uptake cross-sectional survey Delta delta variant Effectiveness effort emergence family history females global pandemic Health healthcare worker herd immunity Hesitancy infected with COVID-19 information less Measures media men Ministry of Health misinformation much lower Multivariate analysis National NEWS P-value pandemic parent parental parents participant Participants Public receive reported SARS-CoV-2 SARS-CoV-2 Delta variant SARS-CoV-2 variant SARS-CoV-2 variants Saudi Arabia Saudi Arabia national survey. seeking social media social media platform social media platforms Sociodemographic Spread subject the vaccine vaccinate vaccination Vaccination Status Vaccine Vaccine hesitancy variable variant variants with COVID-19 women [DOI] 10.1016/j.jiph.2022.06.007 PMC 바로가기 [Article Type] Article
A Case Report of Tolvaptan Therapy for ADPKD Patients With COVID-19. The Need for Appropriate Counselling for Temporary Drug DiscontinuationArticle Published on 2022-07-012022-11-16 Journal: In vivo (Athens, Greece) [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute kidney Acute kidney injury acute respiratory syndrome antagonist Appropriate autosomal dominant Case report cause counseling COVID-19 disease drug Elevation events indicated Infection liver enzyme male management mechanism of action occur pandemic Patient polycystic kidney disease Polydipsia progression receiving receptor renal report risk Safe SARS-CoV-2 SARS-COV-2 infection Side effect Side effects susceptibility symptomatic symptoms appeared temporary the patient therapy Tolvaptan treated Treatment Withdrawal [DOI] 10.21873/invivo.12924 PMC 바로가기
First COVID-19 lockdown resulted in most respiratory viruses disappearing among hospitalised children, with the exception of rhinoviruses첫 번째 COVID-19 잠금으로 인해 병원에 입원한 어린이들 사이에서 리노바이러스를 제외한 대부분의 호흡기 바이러스가 사라졌습니다.Article Published on 2022-07-012022-09-11 Journal: Acta paediatrica (Oslo, Norway : 1992) [Category] 치료기술, [키워드] acute communicable diseases Admission carried cause childhood children communicable communicable diseases COVID-19 COVID-19 pandemic effective emergency room evaluated Face masks Hospital admission Hospital admissions hospitalisation hospitalisations hospitalised Italian Italy less lockdown measure nasal pandemic reduced reducing remained Respiratory disease respiratory diseases respiratory infections respiratory syncytial virus respiratory tract infection respiratory virus respiratory viruses rhinovirus rhinoviruses Rome RSV significantly lower social distancing tested university virus [DOI] 10.1111/apa.16326 PMC 바로가기 [Article Type] Article