The role of pharmaceutical nanotechnology in the time of COVID-19 pandemic코로나19 팬데믹 시대에 제약 나노기술의 역할Review Published on 2020-11-202022-09-10 Journal: Future Microbiology [Category] SARS, 비임상, 임상, 치료제, [키워드] Antiviral antiviral activity approach approved breath Clinical use COVID-19 COVID-19 pandemic COVID-19 treatment COVID-19 treatments demonstrated drug drug toxicity drugs effective therapy Efficacy exhibiting IMPROVE in vitro nanostructured delivery systems Nanotechnology Potential treatment potential treatments tested therapeutic action Toxicity Treatment [DOI] 10.2217/fmb-2020-0118 PMC 바로가기 [Article Type] Review
Poor sensitivity of “AccuPower SARS-CoV-2 real time RT-PCR kit (Bioneer, South Korea)”"AccuPower SARS-CoV-2 real time RT-PCR kit(바이오니아, 한국)" 감도 불량Short Report Published on 2020-11-142022-09-01 Journal: Virology Journal [Category] SARS, 진단, 치료기술, [키워드] 2019-nCoV CDC agency Bioneer carried caused CDC clinical evaluation Clinical use country COVID19 Diagnosis distribution Ecuador Emergency EUA FDA gold gold standard Government government agencies IDT lack limit of detection mandatory molecular objective Pandemia Poor positive Prevent real time Result RT-PCR RT-PCR kit SARS-CoV-2 sensitivity South South Korea specimen Surveillance tested time USA Viral Viral RNA [DOI] 10.1186/s12985-020-01445-4 PMC 바로가기 [Article Type] Short Report
Comparison of clinical characteristics of patients with pandemic SARS-CoV-2-related and community-acquired pneumonias in Hungary – a pilot historical case-control studyOriginal Article Published on 2020-11-112022-11-01 Journal: GeroScience [Category] COVID-19, MERS, SARS, [키워드] abdominal pain acute respiratory syndrome age Aging population approaches AUC C-reactive protein case-control study Clinical characteristics Clinical use community-acquired pneumonia Control coronavirus Department diagnosed diagnostic diarrhoea Emergency external validation help hospital Hungary IMPROVE independent dataset less Logistic Lymphocyte count mean difference nausea outcome pandemic Patient patient triage Pneumonia pneumonia case polymerase chain predict prediction predictor required risk SARS-CoV-2 SARS-COV-2 infection Sex university [DOI] 10.1007/s11357-020-00294-x PMC 바로가기 [Article Type] Original Article
Can pentoxifylline and similar xanthine derivatives find a niche in COVID-19 therapeutic strategies? A ray of hope in the midst of the pandemicResearch article Published on 2020-11-012022-10-05 Journal: European journal of pharmacology [Category] 치료제, [키워드] acute lung injury acute respiratory distress Anti-inflammatory anti-oxidative Antiviral ARDS Asthma blood flow Can clinical feature Clinical outcome clinical study clinical trial Clinical use COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patients Cytokine storm decrease derivative disease drug effective effective drug ENhance Evidence exaggerated immune response excessive inflammation Factor identify immune modulation IMPROVE Infant Inflammation Inflammatory cytokine lack management Methylxanthines multi-organ failure offer Oxygenation pandemic Pentoxifylline Pentoxifylline and caffeine profiles pulmonary diseases pulmonary hypertension required Respiratory function respiratory symptoms severe pneumonia shown specific treatment suppress Symptom syndrome therapeutic tissue TNF-α treat Treatment Tumor xanthine [DOI] 10.1016/j.ejphar.2020.173561 [Article Type] Research article
Noncoding RNAs implication in cardiovascular diseases in the COVID-19 eraReview Published on 2020-10-312022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, MERS, SARS, [키워드] Biomarker cardiovascular disease cardiovascular diseases cardiovascular system caused clinical care clinical manifestation Clinical use COVID-19 COVID-19 disease COVID-19, dysregulation encoding protein Gene Expression homeostasis identify Infection mechanism mRNAs myocardial injury noncoding RNA Noncoding RNAs, pathophysiology Patient Regulation respiratory RNA RNA molecules RNAs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, transcriptomics understanding Vascular [DOI] 10.1186/s12967-020-02582-8 PMC 바로가기 [Article Type] Review
Probiotics in Medicine: A Long DebateImmunology Published on 2020-09-252022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] allergy alveolar amplify approach autoimmune conditions Bacterial Bifidobacterium Central nervous system clinical study Clinical use clinician COVID-19 debate Defense diarrhea Diseases disorder disorders Efficacy and safety Evidence favor gut microbiota Health Host immune system include infections intestinal intestinal epithelium intestine Invasion lactobacillus large sample liver Long lung Macrophage main mechanism Medicine microbiota mucosal occur pandemic Pathogens Pneumonia Population Prevent Probiotics protective role provided reduce reduction Regulation respiratory infection respiratory infections Scientific community Symptom Therapeutic approach therapeutic potential therapy Treatment viral infection viral infections [DOI] 10.3389/fimmu.2020.02192 PMC 바로가기 [Article Type] Immunology
A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures Research Published on 2020-08-272022-10-05 Journal: Nature [Category] SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] ACE2 acute respiratory syndrome administration angiotensin-converting enzyme 2 animal model BALB/c mice caused cells Clinical use clinically coronavirus coronavirus disease COVID-19 demonstrated disease pathogenesis epithelial cell exhibited Express expression Host Human human ACE2 inefficient infect inhibit Interaction Laboratory lower airway mice mouse-adapted SARS-CoV-2 orthologue phenotype primary human airway promoter Prophylactic receptor replicate SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 replication SARS-CoV-2 spike protein severe disease spread to Support therapeutic transgenic mice Transmission Treatment utility viral spike protein virus wild-type [DOI] 10.1038/s41586-020-2708-8 [Article Type] Research
Recent advances in siRNA delivery mediated by lipid-based nanoparticlesReview article Published on 2020-08-062022-10-05 Journal: Advanced drug delivery reviews [Category] 비임상, [키워드] approval approved Bioavailability Blood Cancer Clinical use Degradation disease Diseases effective expected Genetic diseases Inflammatory intractable Lipid nanoparticles LNP Neurological disorder Patisiran pH-responsive ionizable lipid promote recent reported significantly siRNA Small interfering RNA Treatment unique viral infection [DOI] 10.1016/j.addr.2020.07.022 [Article Type] Review article
Repurposing old drugs as antiviral agents for coronavirusesResearch article Published on 2020-08-012022-10-05 Journal: Biomedical journal [Category] SARS, 신약개발, 치료제, [키워드] active against acute respiratory syndrome adverse effect Anti-viral antiviral agent approved Cell Chloroquine Clinical use Compound Concentration Control coronavirus coronavirus disease Coronavirus-2 COVID-19 COVID-19 patients Cytopathic effect dosing schedule drug Drug repurpose EC50 EC50 value HCoV-OC43 HCT-8 cell HCT-8 cells homoharringtonine human coronavirus OC43 humans indication inhibitory activity New nucleocapsid protein pandemic profile proliferation repurposing Result Salinomycin SARS-CoV-2 SARS-CoV-2 drug screened staining therapeutic option Toxicity treating COVID-19 viability were measured [DOI] 10.1016/j.bj.2020.05.003 [Article Type] Research article
In vitro and in vivo identification of clinically approved drugs that modify ACE 2 expressionReport Published on 2020-07-292022-10-31 Journal: Molecular Systems Biology [Category] COVID-19, SARS, [키워드] ACE ACE inhibitor ACEi acute respiratory syndrome angiotensin I‐converting enzyme 2 angiotensin receptor blocker approved drug caused cell lines Chemical biology Clinical use clinically Coronavirus disease 2019 Corticosteroid COVID dataset determine Dexamethasone diabete drug drug treatments drug‐modifying ACE2 expression drugs Effect enzyme expression future work Health higher risk host receptor hypertension identify include Infection kidney lung Microbiology, Virology & Host Pathogen Interaction modify modulation pandemic Patient primary cell provide recent severe acute respiratory syndrome coronavirus 2 significantly suggested transcriptomic data treated upregulate vorinostat [DOI] 10.15252/msb.20209628 PMC 바로가기 [Article Type] Report