Controlled trial – Page 18 – Communicable Diseases Research

Impact of AYUSH interventions on COVID-19: a protocol for a living systematic review and meta-analysis

Covid-19에 대한 Ayush 개입의 영향 : 살아있는 체계적인 검토 및 메타 분석을위한 프로토콜

Study Protocol

Published on 2021-07-282022-08-31
Journal: F1000Research [Category] COVID-19, MERS, meta-analysis, SARS,

Resiliency Engagement and Care in Health (REaCH): a telephone befriending intervention for upskilled rural youth in the context of COVID-19 pandemic—study protocol for a multi-centre cluster randomised controlled trial

REaCH(Resiliency Engagement and Care in Health): COVID-19 대유행의 맥락에서 숙련된 농촌 청소년을 위한 개입과 친해지는 전화 - 다기관 클러스터 무작위 통제 시험을 위한 연구 프로토콜

Study Protocol

Published on 2021-07-282022-09-10
Journal: Trials [Category] SARS, 임상,

[키워드] affected agency assigned Baseline assessment baseline assessments Befriending Care carried clinical Cluster Controlled trial Course COVID-19 COVID-19 pandemic Depression depressive depressive symptom Depressive symptoms disease transmission emotional emotional support Engagement Factors family follow-up assessment follow-up assessments friends Government Government of India Health Health care help India initiative Intervention intervention arm Isolation lockdown loneliness measure Mental mental health offered pandemic participant Primary outcome Primary outcomes promote protocol provided quarantine Questionnaires Randomised control trial randomised controlled trial receive recruited reduce registry resiliency significant others social distancing Social support Society Support symptoms of depression Trial Youth zone
[DOI] 10.1186/s13063-021-05465-5 PMC 바로가기 [Article Type] Study Protocol

Rationale and study design of an early care, therapeutic education, and psychological intervention program for the management of post-intensive care syndrome and chronic pain after COVID-19 infection (PAIN-COVID): study protocol for a randomized controlled trial

COVID-19 감염(PAIN-COVID) 후 집중 치료 증후군 및 만성 통증 관리를 위한 조기 치료, 치료 교육 및 심리 개입 프로그램의 이론적 근거 및 연구 설계: 무작위 대조 시험을 위한 연구 프로토콜

Study Protocol

Published on 2021-07-242022-09-10
Journal: Trials [Category] SARS, 임상,

[키워드] 1:1 acute respiratory distress acute respiratory distress syndrome Anxiety approval approved ARDS Barcelona Care chronic pain cognitive conducted Controlled trial COVID-19 COVID-19 infection Critical illness Critically ill Critically ill patient critically ill patients Depression Deterioration determine develop discharge early stage Effectiveness Follow-up functional functional health groups Helsinki Declaration hospital discharge Hypothesis IMPROVE incidence institutional review board Intervention intervention program life management Mental methodology outcome Pain pandemic Patient patients performed Post ICU syndrome post-traumatic primary endpoint Program proof protocol Psychological intervention Quality of life randomization Randomized randomized clinical trial Randomized controlled trial rationale Registered respiratory distress risk Sample size Secondary objectives severe pain Standard-of-care statistical analysis Statistical analysis plan Stress Study design Study protocol submitted supplementary material susceptible syndrome therapeutic Treatment Trial Trial registration with COVID-19
[DOI] 10.1186/s13063-021-05463-7 PMC 바로가기 [Article Type] Study Protocol

Baidu Jieduan granules, traditional Chinese medicine, in the treatment of moderate coronavirus disease-2019 (COVID-19): study protocol for an open-label, randomized controlled clinical trial

중등도 코로나바이러스 질병-2019(COVID-19) 치료에 사용되는 중국 전통 의학 Baidu Jieduan 과립: 공개, 무작위 대조 임상 시험을 위한 연구 프로토콜

Study Protocol

Published on 2021-07-222022-09-10
Journal: Trials [Category] SARS, 임상, 치료제,

[키워드] 1:1 absence Adverse adverse events AEs Antibiotics antiviral medicine applied Baidu Baidu Jieduan granule baseline Chinese circulating clinical Clinical efficacy clinical evidence conducted control group Controlled clinical trial Controlled trial coronavirus coronavirus disease coughing COVID-19 develop Effect effective Efficacy and safety epidemic disease epidemic diseases evaluate event experimental group fatigue Fever Glucocorticoids Granule granules Health moderate Moderate COVID-19 multicentre Open-label outcome Patient patients with COVID-19 Primary outcome Randomized Randomized controlled trial Randomly receive registry resulting Standard therapy Study protocol supplementary material Support Symptom TCM theory Traditional Chinese medicine treating COVID-19 Treatment treatment group treatment initiation Trial twice a day use of antibiotics
[DOI] 10.1186/s13063-021-05418-y PMC 바로가기 [Article Type] Study Protocol

Effect of telephone counselling on the knowledge, attitude and practices of contacts of confirmed COVID-19 cases in Egypt

Original Research

Published on 2021-07-122022-10-28
Journal: African Journal of Primary Health Care & Family Me [Category] COVID-19, SARS,

[키워드] both group collaborative efforts conducted confirmed case confirmed COVID-19 case Contact Contact tracing contacts of confirmed COVID-19-cases control group Controlled trial coronavirus disease COVID-19 COVID-19 cases COVID-19 stigma Effect Effectiveness Epidemiology experiment experimental group Gender Health authority Health Education Home isolation Infection prevention International Intervention KAP KAP score knowledge Local Measures positive attitude positive correlation public health emergency questionnaire researcher Respiratory illness Result routine surveillance setting significantly statistically significant Surveillance telephone counselling was used World Health Organization
[DOI] 10.4102/phcfm.v13i1.2852 PMC 바로가기 [Article Type] Original Research

Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial

Clinical Trial

Published on 2021-07-102022-10-05
Journal: Lancet (London, England) [Category] Fulltext, MERS, 임상,

[키워드] 95% CI Abstract Administered adverse events age antibody assigned AstraZeneca baseline BNT162b2 booster Cellular immune response ChAdOx1-S control group Controlled trial COVID-19 dose Efficacy enrolled EudraCT FIVE French geometric mean titre Germany headache Heterologous Human IgG immune response immunoassay immunogenicity immunological individual injection site pain interferon-γ Intervention intervention group Intramuscular injection Local Mainz material men Mild moderate multicentre myalgia observation of BNT162b2 Open-label outcome Oxford participant phase 2 trial primary analysis Primary outcome pseudovirus neutralisation assay randomised Randomly RBD RBD protein reaction reactogenicity reactogenicity profile receive Receptor binding domain Registered reported robust safety analysis SARS-CoV-2 SARS-COV-2 infection second dose Serious Adverse Event single dose Spain Spanish systemic adverse events translation Trimeric spike protein university hospital vaccination schedule women
[DOI] 10.1016/S0140-6736(21)01420-3 PMC 바로가기 [Article Type] Clinical Trial

Detection of significant antiviral drug effects on COVID-19 with reasonable sample sizes in randomized controlled trials: A modeling study

무작위 대조 시험에서 합리적인 샘플 크기로 COVID-19에 대한 유의 한 항 바이러스 약물 효과의 검출 : 모델링 연구

Research Article

Published on 2021-07-062022-09-10
Journal: PLoS Medicine [Category] SARS, 임상, 치료기술, 치료제,

[키워드] 1:1 95% CI acute respiratory syndrome coronavirus added analyzed Antiviral antiviral drug antiviral drugs Antiviral effect Antiviral treatment approach association assumed calibrated candidate drug characterized Clinical studies clinical study clinical trial clinical trials cluster analysis Clustering compassionate use conducted confounding variable Controlled trial coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 cumulative demonstrated detect detection development Effect effective enrolled Evidence feature group groups Health help heterogeneity in viral in vitro in vivo models inclusion criteria infected individuals initiated investigated lack log mean difference mechanism methodology mimicking MOST observational studies observational study observé outcome P -value parameter Patient placebo group quantified randomization Randomized Randomized controlled trial Randomized controlled trials recruit reduced reduction in required researcher respiratory Sample size sample size estimates sample sizes SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly Simulation small sample size statistically significant Study design symptom onset Symptoms the timing time lag treated Treatment treatment allocation treatment initiation trials Viral viral dynamics Viral load viral replication virus Virus shedding was reduced
[DOI] 10.1371/journal.pmed.1003660 PMC 바로가기 [Article Type] Research Article

A literature review of consent declines and consent withdrawals in randomized controlled trials conducted during the COVID-19 pandemic

COVID-19 전염병 동안 수행된 무작위 대조 시험에서 동의 거부 및 동의 철회에 대한 문헌 검토

Review

Published on 2021-07-012022-09-11
Journal: Journal of postgraduate medicine [Category] SARS, 임상,

Evaluating the methodology of studies conducted during the global COVID-19 pandemic: A systematic review of randomized controlled trials

전 세계 COVID-19 대유행 기간 동안 수행된 연구 방법론 평가: 무작위 대조 시험의 체계적인 검토

Article

Published on 2021-07-012022-09-11
Journal: Journal of integrative medicine [Category] SARS, 임상,

[키워드] acute respiratory syndrome allocation concealment Blinding China Chongqing clinical care Clinical research Cochrane Handbook collected Comparisons conducted Consistency construction Controlled trial coronavirus disease Coronavirus disease 2019 Coronavirus pneumonia Coronavirus-2 COVID-19 COVID-19 RCT COVID-19 RCTs criteria data extraction deficiencies deficiency Descriptive statistics deviation disease eligible epidemic disease epidemic diseases Evaluating Evidence Excerpta Medica database exclusion exclusion criteria FIVE for inclusion global pandemic Guidance Handbook help implementation IMPROVE Inclusion information Infrastructure medRxiv Methodological quality methodology nCoV network Novel coronavirus novel coronavirus pneumonia outcome outcomes pandemic participant platform positive protocol provided Randomized controlled trial Randomized controlled trials RCT RCTs recruitment reported Repository Research researchers resulting review RTC Sample size Science Screening searched selective Seven Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus-2 Support systematic review systematic reviews therapeutic Therapeutic evidence. treating COVID-19 Treatment trials utility Variability Version VIP was done
[DOI] 10.1016/j.joim.2021.03.003 PMC 바로가기 [Article Type] Article

BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial

우간다 신생아의 이종 감염성 질환에 대한 BCG- 유도 비특이적 영향 : 조사관 맹인 무작위 대조 시험

Articles

Published on 2021-07-012022-09-06
Journal: The Lancet. Infectious Diseases [Category] Communicable Disease,

[키워드] 1:1 Abstract addition age all-cause mortality Alter analysed analyses assigned BCG BCG vaccination benefit Birth blind block size block sizes blood sample Blood samples change clinically clinician Comparisons computer-generated Concentration Consent contributed Controlled Controlled trial Cord blood discharged Effect Effects eligible enrolled Entebbe Families finding Follow-up for inclusion funding geometric geometric mean geometric mean ratios gestational age group hazard ratio healthy hepcidin Heterologous hospital IFNγ IL-10 IL-1β IL-6 IL1B IL6 immunological incidence increase in Infant Infants infections Infectious disease inhibited Innate immunity international standard investigated investigators life Luganda material medical intervention modified intention-to-treat mononuclear cell morbidity morbidity and mortality mother Neonatal neonatal period no significant difference non-specific number outcome parent parents participant Peripheral blood Peripheral blood mononuclear cells primary clinical outcome promoter promoter region PROTECT randomisation randomised randomised controlled trial Randomly receive recruited reduce reductions reductions in Registered required saturation Standard Standard dose stratified by sex TNF Transferrin translation Trial Tuberculosis Uganda vaccination Wellcome Trust were excluded with HIV withdrawn
[DOI] 10.1016/S1473-3099(20)30653-8 PMC 바로가기 [Article Type] Articles