Design of the SARS-CoV-2 RBD vaccine antigen improves neutralizing antibody responseArticle Published on 2022-09-162022-11-15 Journal: Science Advances [Category] SARS, 변종, 진단, [키워드] amino acid change change Characteristics conserved COVID distribution elicit ENhance immune response immunogen immunogens IMPROVE in vitro Mutation neutralizing antibody Neutralizing antibody response neutralizing epitopes nine platform RBD Receptor binding domain sequence Spike protein the SARS-CoV-2 Vaccine vaccine antigen vaccine platform Vaccines variants of concern [DOI] 10.1126/sciadv.abq8276 PMC 바로가기
Bioinformatics and systems biology approach to identify the pathogenetic link of Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue SyndromeArticle Published on 2022-09-162022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome analyses Analysis approach bioinformatics bioinformatics analyses biological function caused CD8A Clinical practice collected Compound condition coronavirus COVID COVID-19 infection COVID-19 pandemic CXCL8 database dataset demonstrated develop discharge enrichment analysis Evidence fatigue Genes greater healthcare help hub protein identify IL-1B IL-6 Infection information Interaction Intersection Laboratory Long Long COVID ME/CFS mechanism multicenter Myalgic encephalomyelitis/chronic fatigue syndrome network analysis nine Ontology pathway enrichment performed PPI PPI network predicted protein-protein interaction Protein–protein interaction protein–protein interaction network required SARS-CoV-2 signaling pathway Symptom syndrome Systems biology therapeutic drug TP53 Transcription transcription factor [DOI] 10.3389/fimmu.2022.952987 PMC 바로가기
Rapamycin and inulin for booster vaccine response stimulation (RIVASTIM)-rapamycin: study protocol for a randomised, controlled trial of immunosuppression modification with rapamycin to improve SARS-CoV-2 vaccine response in kidney transplant recipientsArticle Published on 2022-09-152022-11-15 Journal: Trials [Category] SARS, 진단, [키워드] 1:1 binding domain Booster vaccine cell-mediated response clinical Controlled trial COVID COVID-19 COVID-19 vaccination COVID-19 vaccine death develop disease severity dose Effectiveness Efficacy ENhance hospitalisation humoral hypothesise IgG immune cell population immunological Immunosuppression IMPROVE include increased risk Intervention kidney transplant recipient kidney transplant recipients Kidney transplantation live SARS-CoV-2 Modification mTOR inhibitor multicentre neutralisation New outcome participant Prednisolone Primary outcome proportion Protective protective immunity public health randomised randomised controlled trial Rapamycin recipient reduce reduced regimen registry responses SARS-CoV-2 SARS-CoV-2 vaccine secondary serological Sirolimus Standard of care Study protocol Tolerability Trial vaccination Vaccine vaccine response virus [DOI] 10.1186/s13063-022-06634-w PMC 바로가기
Assessing COVID-19 vaccination strategies in varied demographics using an individual-based modelArticle Published on 2022-09-152022-11-15 Journal: Frontiers in Public Health [Category] SARS, 변종, 치료기술, 치료제, [키워드] age agent-based model (ABM) applied Assessing asymptomatic infections booster doses Characteristics Contact COVID COVID- 19 COVID-19 COVID-19 vaccination COVID-19 vaccine demographics distribution distributions Effectiveness Efficiency help Hospitalization household size individual individual-base model Infection infection rate Intervention New non-pharmaceutical interventions (NPIs) NPI NPIs outbreak parameter Prevent Probability reproductive responses against SARS-CoV-2 severe disease structures subpopulation symptomatic Total unique vaccinate vaccination Vaccination strategies Vaccination strategy variants variants of SARS-CoV-2 [DOI] 10.3389/fpubh.2022.966756 PMC 바로가기
PD-1 and ICOS counter-regulate tissue resident regulatory T cell development and IL-10 production during fluArticle Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] accumulated CD4 Cell characterized co-stimulatory receptor COVID Critical Express expressed flu fluorescent FOXP3 GFP heterogenous human population iCoS IL-10 Immune homeostasis immunopathology in vivo Infection infections Influenza influenza infection influenza infections labeling lung tissue memory T cells molecular feature PD-1 proinflammatory promote Regulatory Regulatory T cell repeated reporter respiratory infectious disease response reveal secondary infections shown Signaling signaling pathway suppress T cell T cell response T cells tissue tissue repair tissue resident T cells. transcription factor Treg Treg cell Treg cells Tuberculosis [DOI] 10.3389/fimmu.2022.984476 PMC 바로가기
SARS-CoV-2 and COVID-19: A Narrative ReviewArticle Published on 2022-09-062022-11-16 Journal: British journal of biomedical science [Category] SARS, 변종, [키워드] caused Clinical data component COVID COVID-19 death Epidemiology Long COVID narrative reported review SARS-CoV-2 vaccination variants viral disease World Health Organisation [DOI] 10.3389/bjbs.2022.10426 PMC 바로가기
UV-C Light Completely Blocks Aerosol Transmission of Highly Contagious SARS-CoV-2 Variants WA1 and Delta in HamstersArticle Published on 2022-09-062022-11-16 Journal: Environmental science & technology [Category] SARS, 변종, [키워드] activities adhere aerosol block COVID COVID19 Delta effective Effectiveness element hamster individual investigated LIGHT measure Population Prevent prevented reduce risk SARS-CoV-2 SARS-CoV-2 transmission Spread susceptible Syrian Golden hamsters Transmission transmission of SARS-CoV-2 ultraviolet light UV-C virus WA1 wavelength [DOI] 10.1021/acs.est.2c02822 PMC 바로가기
Case report: Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVIDArticle Published on 2022-09-052022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, 치료제, [키워드] acute phase Antigen Appendix CD68 Convalescent patients COVID COVID-19 defined Diagnosis exhibited explained gastrointestinal tract Immune cell Immunocompromised patient immunohistochemistry individual Long COVID macrophage marker multiplex multiplex immunohistochemistry nucleocapsid protein occur Patient positive Post-acute COVID-19 syndrome raise reported residual SARS-CoV-2 RNA SARS-CoV-2 SARS-COV-2 infection Symptom symptom onset target the SARS-CoV-2 virus tissue tissues Viral antigen viral nucleocapsid protein viral persistence viral replication Viral RNA virus World Health Organization [DOI] 10.3389/fimmu.2022.939989 PMC 바로가기
Orbital myositis and scleritis after anti-SARS-CoV-2 mRNA vaccines: A report of three casesCase Report Published on 2022-09-042024-09-04 Journal: European Journal of Ophthalmology [Category] 대상포진, [키워드] coronavirus COVID mRNA BNT162b2 vaccine ophthalmic adverse reactions mRNA-1273-vaccine ophthalmic adverse reactions ocular scleritis orbital myositis [DOI] 10.1177/11206721221123780 PMC 바로가기 [Article Type] Case Report
All-People-Test-Based Methods for COVID-19 Infectious Disease Dynamics Simulation Model: Towards Citywide COVID TestingArticle Published on 2022-09-022022-11-15 Journal: International Journal of Environmental Research an [Category] SARS, 치료기술, 치료제, [키워드] Asymptomatic case asymptomatic infection collected Community Contact tracing COVID COVID-19 COVID-19 pandemic COVID-19 sampling pooling cumulative death Defense described Dynamics Effect effective Epidemic evaluated experiment Follow-up help Hong Kong Infection Infectious disease information International Large-scale testing measure Mild symptom mobile app precise tracking technology parameter problem reduce reported required researcher Screening screening method SETPG (A + I) RD + APT model Simulation Spread symptomatic infection tested Testing the epidemic the United State timespan Total Transmission Transmission dynamics variable virus [DOI] 10.3390/ijerph191710959 PMC 바로가기