Coronaviruses in farm animals: Epidemiology and public health implicationsReview Published on 2020-09-252022-10-28 Journal: Veterinary medicine and science [Category] COVID-19, [키워드] animal characterized Contact coronavirus Coronaviruses country CoV CoV infection CoVs distribution domestic animals driver FIVE Host host jump Human Impact implication Increasing management Mild Mutation pathogen Prevalence public health Recombination reported Respiratory disease responsible Severe infection severity Surveillance terrestrial Transmission Transport virus widespread wild animal [DOI] 10.1002/vms3.359 PMC 바로가기 [Article Type] Review
Coronaviruses in wild birds – A potential and suitable vector for global distributionReview Published on 2020-09-242022-10-28 Journal: Veterinary medicine and science [Category] Coronavirus, MERS, [키워드] adaptive immune system Anseriformes avian CoV bronchitis caused Charadriiformes Community continuous monitoring coronavirus Coronaviruses CoV CoVs Deltacoronavirus distribution Evidence Galliformes Gammacoronavirus global distribution Gruiforme Gruiformes imperative morbidity Mortality Novel coronavirus outbreak Pelecaniformes possession recorded Research Spread Travel vector vectors widespread wild birds zoonotic [DOI] 10.1002/vms3.360 PMC 바로가기 [Article Type] Review
Identification of a Membrane Binding Peptide in the Envelope Protein of MHV CoronavirusArticle Published on 2020-09-222022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Amino acid Antigen binding Cell cholesterol coding sequence coronavirus CoV CoVs distribution DPPC E protein Endoplasmic reticulum envelope envelope protein ERGIC expressing expression full-length function Giant Golgi GUV identification identify in silico insect cells intestinal mammal mammalian membrane MHV mouse mutant Neurological disease peptide peptides positive predicted Replication RNA virus sphingomyelin tested Vesicle virus were expressed wild type [DOI] 10.3390/v12091054 PMC 바로가기 [Article Type] Article
Flavonoids: A complementary approach to conventional therapy of COVID-19?Article Published on 2020-09-182022-10-29 Journal: Phytochemistry Reviews [Category] COVID-19, [키워드] 3CLpro analyzed Antiviral effect antiviral therapeutics antiviral therapy antivirals approach caused complementary Compound compounds contagious coronavirus Coronaviruses COVID-19 CoVs disease effective enzyme flavonoids future work globe human coronavirus human CoVs identify inhibiting International knowledge MERS MERS-CoV natural outbreak Papain-like protease plant PLPro positive-sense RNA viruses protease quercetin Research SARS-CoV SARS-CoV-2 Spread stimulated Structure Therapeutic treatment therapy this new coronavirus viruses [DOI] 10.1007/s11101-020-09720-6 PMC 바로가기 [Article Type] Article
The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2Genome Replication and Regulation of Viral Gene Expression Published on 2020-09-162022-10-30 Journal: Journal of Virology [Category] COVID-19, SARS, [키워드] activities activity acute respiratory syndrome affecting Alpha Amino acid antiviral drug Betacoronavirus betacoronaviruses boost can be used complex coronavirus CoV CoVs Critical decrease displaying domains enzymatic activity enzyme evaluated example Exoribonuclease Frequency Genetic genetics genome replication guanine-N7-methyltransferase In vitro assay MERS-CoV MHV Middle East MONITOR mouse hepatitis virus mRNA mutant mutants Mutation nidovirus nonstructural protein nsp14 Nsps observation occurred phenotype Phenotypes progeny promote Proofreading purified replicase replicate Replication replication fidelity replicative reported respiratory syndrome coronavirus reverse genetics RNA genome RNA synthesis SARS-CoV SARS-CoV-2 sequence identity single mutant subunit Support thought viral RNA synthesis viruses while [DOI] 10.1128/JVI.01246-20 PMC 바로가기 [Article Type] Genome Replication and Regulation of Viral Gene Expression
Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsisReview Published on 2020-09-112022-10-31 Journal: Human Genomics [Category] COVID-19, SARS, [키워드] absence ACE ACE2 analysed article association candidate gene caused CD209 CLEC4M Clinical diagnosis clinical phenotypes cohorts complex interplay complications coronavirus CoV COVID-19 COVID-19 pandemic CoVs disease-associated Diseases eligible FCER2 genetic association genetic background genetic susceptibility Genetic variant Genomic biomarker Genotype HLA haplotype Host human host implicated include Infection infectious agent investigated knowledge L-SIGN large cohort mechanism MERS MERS-CoV meta-analyses MOST outbreak outcome patients with COVID-19 phenotype Phenotypes polymorphism predictor Primary outcome PROSPERO database protocol provided question raised Registered robust SARS-CoV-1 SARS-CoV-2 severity statistical Symptom systematic review tested the SARS-CoV-2 TLR4 TNF-α Variability variant with COVID-19 [DOI] 10.1186/s40246-020-00280-6 PMC 바로가기 [Article Type] Review
In vitro virucidal activity of Echinaforce®, an Echinacea purpurea preparation, against coronaviruses, including common cold coronavirus 229E and SARS-CoV-2Research Published on 2020-09-092022-10-28 Journal: Virology Journal [Category] COVID-19, SARS, [키워드] 229E Antiviral antivirals Case fatality rate Cell Cell culture cell lines common cold common cold coronavirus common cold Coronaviruses comparable Concentration concentrations Contact coronavirus Coronaviruses CoV COVID-19 CoVs Dilution droplet Echinacea effective evaluate evaluated Gastrointestinal symptom HCoV-229E highly pathogenic Human in vitro inactivated Infection infections inhibit investigated MERS MERS-CoV Middle East mild respiratory morbidity and mortality nasal epithelium natural infection observé outbreak Post-infection prevention prophylactic treatment Prophylaxis protective effect respiratory respiratory epithelium Result SARS-CoV-1 SARS-CoV-2 similarities thought Treatment virucidal virus particle virus propagation zoonotic [DOI] 10.1186/s12985-020-01401-2 PMC 바로가기 [Article Type] Research
Polyphenols vs. Coronaviruses: How Far Has Research Moved Forward?Review Published on 2020-09-082022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] 3-chymotrypsin-like protease antiviral activity antiviral role caused coronavirus CoVs driving Efficacy Epidemic herbal extracts in vitro investigated involved knowledge Laboratory Papain-like protease polyphenol polyphenols protease researcher SARS-CoV-2 screened target [DOI] 10.3390/molecules25184103 PMC 바로가기 [Article Type] Review
Evaluation of Neutralizing Antibodies Against Highly Pathogenic Coronaviruses: A Detailed Protocol for a Rapid Evaluation of Neutralizing Antibodies Using Vesicular Stomatitis Virus Pseudovirus-Based AssayMicrobiology Published on 2020-09-042022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Against biosafety BSL-2 BSL-3 cellular receptors condition conditions Coronaviruses CoV CoVs detect determine development evaluate facilitate generate gold standard handling highly pathogenic highly pathogenic CoV highly pathogenic CoVs host cell human coronavirus immune response immunogenic infected individuals inhibitor Laboratory Live virus MERS-CoV Middle East Middle East respiratory syndrome Coronavirus NAb Neutralization assay neutralizing antibody Prevalence Protein protocol pseudovirus Pseudovirus neutralization assay public health Rapid researcher S protein Safe SARS-CoV-2 serological Serological assay serum sample severe acute respiratory syndrome coronavirus 2 Surface glycoprotein the S protein Vaccine Vaccines vesicular vesicular stomatitis virus vesicular stomatitis virus pseudovirus viral entry VSV while [DOI] 10.3389/fmicb.2020.02020 PMC 바로가기 [Article Type] Microbiology
Possibility for reverse zoonotic transmission of SARS-CoV-2 to free-ranging wildlife: A case study of batsSARS-CoV-2가 방목하는 야생 동물에 역동물성 전파 가능성: 박쥐 사례 연구Review Published on 2020-09-032022-08-13 Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences, SARS, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 bat bats beta-coronavirus complicate consequence coronavirus COVID-19 pandemic CoVs distribution Health highlight host range Human immunologically Impact impacts infecting Infection lead Lineage measure naïve North pandemic populations public health Research reservoir respiratory risk SARS-CoV-2 severe acute respiratory syndrome Coronavirus susceptible Transmission Viral virus wildlife zoonotic transmission β-CoV β-CoVs [DOI] 10.1371/journal.ppat.1008758 PMC 바로가기 [Article Type] Review