Immune Determinants of Viral Clearance in Hospitalised COVID-19 Patients: Reduced Circulating Naïve CD4+ T Cell Counts Correspond with Delayed Viral ClearanceArticle Published on 2022-09-022022-11-15 Journal: Cells [Category] SARS, 진단, [키워드] antibody B cell basophils CD4 T cells CD4+ CD4+ T cell CD4+ T cells cellular component correlated count COVID-19 Critical cytokine profile Delayed determinant disease deterioration help hospitalised patient Humoral response IL-9 immune activation immune parameter less longitudinal design magnitude MIF moderate Monocytes naïve naïve CD4+ T cell neutralising Neutralising Antibodies Neutrophils pro-inflammatory risk stratification SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease T cell Th2 the timing tissue damage viral clearance [DOI] 10.3390/cells11172743 PMC 바로가기
Tracking the incidence and risk factors for SARS-CoV-2 infection using historical maternal booking serum samplesArticle Published on 2022-09-022022-11-15 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] Antenatal anti-RBD antibody binding domain community transmission Critical death Deprivation determine Effect Estimated Evidence groups hospitalisation incidence London NHS Outbreaks pandemic peaked Prevalence quantified reflect resource risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor serum sample serum samples significant interaction tested the SARS-CoV-2 virus Transmission dynamics [DOI] 10.1371/journal.pone.0273966 PMC 바로가기
SARS-CoV-2 variants and spike mutations involved in second wave of COVID-19 pandemic in IndiaArticle Published on 2022-09-012022-11-15 Journal: Transboundary and emerging diseases [Category] SARS, 변종, 진단, 치료기술, [키워드] Against Alpha Amino acid analysed Analysis B.1.1.7 B.1.617.2 biological significance carried circulating circulation country COVID-19 COVID-19 pandemic COVID-19 second wave Critical cytoplasmic domain domains dominant lineage fusion peptide GISAID help India involved Kashmir Lineage Local MONITOR Mutation mutations N-terminal domain National Neutralizing antibodies pathogenicity Prevalence Protein Receptor binding domain regimen reported S protein SARS-CoV-2 SARS-CoV-2 genomic sequence SARS-CoV-2 variant second wave signal peptide spike mutation Spike protein Spike protein variants the S protein transmembrane region Vaccine vaccine breakthrough infections variant viral mutation virus were recorded whole-genome Whole-genome sequence whole-genome. [DOI] 10.1111/tbed.14508 PMC 바로가기
The long-term buffering effect of sense of coherence on psychopathological symptoms during the first year of the COVID-19 pandemic: A prospective observational studyObservational Study Published on 2022-09-012022-10-05 Journal: Journal of psychiatric research [Category] 임상, [키워드] affected affecting changes in COVID-19 COVID-19 outbreak COVID-19 pandemic Critical decrease demonstrated Factor General population Germany growth individuals Interaction mental health modulating pandemic predicted prospective observational study Research Resilience Rumination sense sense of coherence significantly Symptom Symptoms trajectory were used [DOI] 10.1016/j.jpsychires.2022.07.004 PMC 바로가기 [Article Type] Observational Study
Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN SurveyResearch article Published on 2022-09-012022-10-05 Journal: Pharmacological research [Category] 바이오마커, [키워드] Administered ascorbic acid Borg Combination COVID-19 Critical Effect effort Endothelial dysfunction endothelial function Evidence favorable effect IMPROVE in both groups indicate L-Arginine long-COVID oxidative stress pathophysiology Patient receiving recent reduce Result significant difference significantly lower survey Symptom Symptoms Treatment treatment arm two groups typical symptom Vitamin Vitamin C [DOI] 10.1016/j.phrs.2022.106360 [Article Type] Research article
Innovation in crisis: The role of ‘exaptive relations’ for medical device development in response to COVID-19Research article Published on 2022-09-012022-10-05 Journal: Technological Forecasting and Social Change [Category] 신약개발, 유전자 메커니즘, 진단, [키워드] addition Collaborative effort contribute COVID-19 COVID-19 pandemic Critical debatable Drawing events Exaptation healthcare Innovation Medical innovation organization subject [DOI] 10.1016/j.techfore.2022.121863 [Article Type] Research article
Clinical and Epidemiological Correlates of Low IFN-Gamma Responses in Mitogen Tube of QuantiFERON Assay in Tuberculosis Infection Screening During the COVID-19 Pandemic: A Population-Based Marker of COVID-19 Mortality?Research article Published on 2022-09-012022-10-05 Journal: Archivos de bronconeumología [Category] 바이오마커, 임상, [키워드] abnormal immune response abnormality Affect Asturia CD8 clinical Cohort correlation COVID-19 COVID-19 pandemic COVID-19 pneumonia COVID-19 severity Critical death epidemiological Evolution gold hospitalized patient IFN-gamma IGRA immune profiling Immunosuppressant implication latent tuberculosis infection LTBI mitogen Mortality occur pandemic Patient patients percentage Phytohemagglutinin Pneumonia population level positive QuantiFERON radiological finding reduction response Result SARS-CoV-2 Screening significantly Spain subset T cell T-cell the disease tube with COVID-19 [DOI] 10.1016/j.arbres.2022.01.011 [Article Type] Research article
Evolving strategy for an evolving virus: Development of real-time PCR assays for detecting all SARS-CoV-2 variants of concern진화하는 바이러스에 대한 진화하는 전략: 우려되는 모든 SARS-CoV-2 변이체를 검출하기 위한 실시간 PCR 분석법 개발Article Published on 2022-09-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] Alpha Amino acid amino acid change amino acid changes approach B.1.1.7 Beta Canada characterized clinical sensitivity clinical specificity complementary COVID-19 Critical cross-reactivity Delta detect development discriminatory mutation E gene E484K FIVE Gamma Genome sequencing implementation K417N L452R less limit of detection Lineage molecular MONITOR N501Y Negative predictive value nucleotide omicron Omicron variants P681 Pathogens PCR PCR assays positive Positive predictive value positive predictive values positive sample predictive values reaction real-time PCR assay real-time reverse transcriptase real-time RT-PCR replacement respiratory respiratory pathogen responsible reverse transcriptase rRT-PCR SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequencing SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Single nucleotide polymorphism single nucleotide polymorphisms specificity Spike protein subset Surveillance target the SARS-CoV-2 Variability variant variants variants of concern VoC VOCs while wild-type Δ69-70 [DOI] 10.1016/j.jviromet.2022.114553 PMC 바로가기 [Article Type] Article
Association of mental health with clinical outcomes in hospitalized patients with moderate COVID-19Research article Published on 2022-09-012022-10-05 Journal: Journal of affective disorders [Category] COVID19(2023년), SARS, 바이오마커, [키워드] addition adjusted adjusted hazard ratio Admission age Anxiety association Clinical outcome clinical outcomes clinically conducted coronavirus disease COVID-19 COVID-19 pandemic Cox regression analysis Critical death Depression Diagnosis discharge duration of hospitalization Epidemiology HADS highlight Hospital stay hospitalized patient immune response incidence Laboratory male management marker mental health mental health problem moderate Moderate COVID-19 objective participant Patient Primary outcome prospective cohort study Result risk scale secondary outcome significantly were assessed Wuhan, China [DOI] 10.1016/j.jad.2022.05.047 [Article Type] Research article
Longitudinal changes in inflammatory biomarkers among patients with COVID-19: A nationwide study in IcelandCOVID-19 환자의 염증성 바이오마커의 종단적 변화: 아이슬란드의 전국 연구Article Published on 2022-09-012022-09-11 Journal: Acta Anaesthesiologica Scandinavica [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Admission admitted to ICU Ambulatory care Analysis Biomarker Biomarkers blood cell blood test blood tests C-reactive protein C-reactive protein (CRP Care Chain Reaction changes in Clinical outcome clinical outcomes collected correlated COVID-19 Critical Critical care CRP D-dimer death died disease severity elevated Evolution ferritin ferritin level ferritin levels groups hospital Hospitalization Hospitalized Iceland ICU individual Infection Inflammatory biomarker inflammatory biomarkers intensive care Laboratory laboratory markers Landspitali longitudinal longitudinal change longitudinal changes Lower lymphocyte Lymphocyte count measurement medical record neutrophil neutrophil counts occurred onset of symptoms outcome parameter Patient patients patients with COVID-19 plasma plasma CRP polymerase chain polymerase chain reaction positive predictor procalcitonin real-time polymerase chain reaction required RT-PCR SARS-CoV-2 scatterplot stratified sustained tested the mean Treatment university White blood cell [DOI] 10.1111/aas.14109 PMC 바로가기 [Article Type] Article