Exploring the Relevance of Senotherapeutics for the Current SARS-CoV-2 Emergency and Similar Future Global Health ThreatsReview Published on 2020-04-082022-10-31 Journal: Cells [Category] COVID-19, [키워드] caused cellular senescence consequence COVID-19 current death rate Deleterious disease Efficacy Emergency exacerbated Extracellular vesicles Future global health IL-6 Infection Inflammation Inflammatory response Influenza virus Mitochondria mutated Older Prevent Relevance replication efficiency Research RNA viruses ruxolitinib SARS-CoV SARS-CoV-2 SASP inhibitors senescent cell senescent cells senolytics senoptotics therapeutic strategy those with comorbidities threat treating COVID-19 Vaccine viral infection virus [DOI] 10.3390/cells9040909 PMC 바로가기 [Article Type] Review
Evolution of a novel chimeric maltotriose transporter in Saccharomyces eubayanus from parent proteins unable to perform this function이 기능을 수행할 수 없는 모 단백질로부터 Saccharomyces eubayanus의 새로운 키메라 말토트리오스 수송체의 진화Research Article Published on 2019-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive breakpoint bypassing Cell changes in Chimera chimeric classic Deleterious determine domain duplicate gene ectopic recombination epistatic interaction epistatic interactions Evolution example experiment function functional functions gene encoding Gene Expression gene sequence generate genes encoding Genetic hybrid Interaction lack less limit locus MALT malt extract maltose maltotriose mapped molecular multiple mutation multiple mutations occurred overexpressing paralog paralogs performed Point mutation proceed Protein Proteins provide Recombination Research Saccharomyces cerevisiae sequence strain Strains Substitution substitutions sugar Support the cell thought Transport transporter while wild strain wild strains yeast [DOI] 10.1371/journal.pgen.1007786 PMC 바로가기 [Article Type] Research Article
Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmissionArticle Published on 2018-10-112022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] acute respiratory syndrome attenuation cDNA Cell Cell culture clone coronavirus deleted Deleterious early stage Endemic Epidemic founder effect Frame genetic change Host human Angiotensin-converting enzyme human-to-human transmission humans implication independent independent of initial lentiviral Mutation nucleotide deletion ORF8 provided receptor reflect Replication resulting retrospective SARS-coronavirus SARS-CoV type I interferon virus [DOI] 10.1038/s41598-018-33487-8 PMC 바로가기 [Article Type] Article
A Thermolabile Aldolase A Mutant Causes Fever-Induced Recurrent Rhabdomyolysis without Hemolytic Anemia열불안정성 알돌라제 A 돌연변이는 용혈성 빈혈 없이 발열로 인한 재발성 횡문근 융해증을 유발합니다Research Article Published on 2014-11-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulated affected ALDOA Aldolase arginine arginine supplementation betaine cause chaperones Cytokines deficiency Deleterious Dexamethasone droplet erythrocytes Exacerbation expand febrile glycerol hemolytic hemolytic anemia high temperature homozygous mutation illnesses in vitro Lipid lipid droplets mechanism myoblast myoblasts Myoglobinuria Myopathy Patient Protein Recurrent reduced reported rescued rhabdomyolysis severe disease thermolability tissue specific Treatment triggered was increased [DOI] 10.1371/journal.pgen.1004711 PMC 바로가기 [Article Type] Research Article
The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral PathogenesisResearch Article Published on 2014-08-142022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activate activating Activation acute respiratory syndrome addition administration analyses assays caused Cell cellular complementary confocal microscopy coronavirus cytoplasm decrease decreased expression Deleterious demonstrated determinant domain E protein Elimination envelope Epidemic exacerbated functional genetics highlight immune response immunopathology in vivo increase in induce infecting Infection Inflammation Inflammatory cytokine Inflammatory cytokines inhibitor interact Interaction interactions involved lung lung damage MAPK mice modulating Mortality motif nucleus overexpression parental pathway potential therapeutic target Protein Proteins proteomic recombinant reduce reduction in respiratory SARS-CoV SARS-CoV E SARS-CoV infected cells SARS-CoV infection siRNA survival triggered triggering virulence virus virus attenuation was reduced yeast [DOI] 10.1371/journal.ppat.1004320 PMC 바로가기 [Article Type] Research Article
Coronavirus Gene 7 Counteracts Host Defenses and Modulates Virus VirulenceResearch Article Published on 2011-06-092022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence accelerated accessory gene acquisition Activation Analysis Antiviral antiviral response Apoptosis assay association Author benefit binding caspase catalytic caused Cell cellular RNA clinical disease compared conserved coronavirus CoV cultures Cytopathic effect Defense Degradation Deleterious demonstrated eIF2α ENCODE eukaryotic translation evade Evolution expression Genome growth Host host antiviral response host cell hydrophobic immune response indicated Infected infected cells Infection Innate inoculation Interaction led to mechanism modify modulation molecular mechanism motif mutant mutant virus Newborn observation parental pathology Pathways persistence Phosphorylation promoted Protein protein phosphatase 1 provided pull-down reducing required RNA degradation RNA viruses RNase selective sequence subunit suggested survival TGEV tissue translational transmissible gastroenteritis virus Viral RNA virulence virus virus infection [DOI] 10.1371/journal.ppat.1002090 PMC 바로가기 [Article Type] Research Article
Molecular mechanisms of severe acute respiratory syndrome (SARS)Review Published on 2005-01-202022-10-28 Journal: Respiratory Research [Category] Coronavirus, [키워드] acute respiratory syndrome approach caused contribute coronavirus Deleterious Effect effort Epidemics Features Genome Health immune immune system indirect effect infections Infectious disease Interaction Laboratory mechanism molecular mechanisms morbidity and mortality mutability Novel coronavirus Occurrence offer Open reading frame outbreak Pathogenesis Prevent pulmonary pathological Region required Research Respiratory disease SARS SARS-CoV severe Severe acute respiratory syndrome target cell the disease therapy vaccination Vaccine viral genome virulence virus widespread [DOI] 10.1186/1465-9921-6-8 PMC 바로가기 [Article Type] Review