Can B cell-deficient patients rely on COVID-19 vaccine-induced T-cell immunity?B 세포 결핍 환자가 COVID-19 백신 유도 T 세포 면역에 의존할 수 있습니까?Article Published on 2022-06-012022-09-12 Journal: British Journal of Haematology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome antibody treatment B cell-deficient patients Can CD8 T cell CD8 T-cell response clinical trial coronavirus disease Coronavirus disease 2019 (COVID-19) Coronavirus-2 COVID-19 COVID-19 vaccination develop epitope healthy controls Humoral response less lymphoma Patient Prevent respond response responses SARS-CoV-2 T-cell T-cell immunity T-cell Response treated treated patient Vaccine Vaccines [DOI] 10.1111/bjh.18210 PMC 바로가기 [Article Type] Article
Generation, characterization, and protective ability of mouse monoclonal antibodies against the HA of A (H1N1) influenza virusArticle Published on 2022-06-012023-06-24 Journal: Journal of medical virology [Category] 신종인플루엔자, [키워드] epitope hemagglutination influenza H1N1 monoclonal antibody neutralization [DOI] 10.1002/jmv.27584
Designing and characterization of a SARS-CoV-2 immunogen with receptor binding motif grafted on a protein scaffold: An epitope-focused vaccine approach단백질 스캐폴드에 이식된 수용체 결합 모티프가 있는 SARS-CoV-2 면역원의 설계 및 특성화: 에피토프 중심 백신 접근 방식Article Published on 2022-06-012022-09-12 Journal: International journal of biological macromolecules [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 angiotensin Antibody Response antigenic approach caused COVID-19 pandemic effective epitope healthcare immunized immunized mice Immuno-focusing induce Infectious disease interferon γ mice natural infection neutralization neutralizing antibody Non-neutralizing antibodies non-neutralizing epitope predominant Protein RBD RBM Receptor binding domain receptor binding motif robust SARS-CoV-2 SARS-COV-2 infection Scaffold sera Spread T cell T cell response the antibody response the disease the spike protein Vaccine [DOI] 10.1016/j.ijbiomac.2022.04.148 PMC 바로가기 [Article Type] Article
A conserved subunit vaccine designed against SARS-CoV-2 variants showed evidence in neutralizing the virusSARS-CoV-2 변이체에 대해 설계된 보존 소단위 백신은 바이러스를 중화하는 증거를 보여주었습니다Article Published on 2022-06-012022-09-11 Journal: Applied Microbiology and Biotechnology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] addition affinity analyzed antibody approach B-cell response conserved coronavirus coronavirus disease country Coverage COVID-19 Cytopathic effect docking domain Efficiency elicit envelope envelope protein epitope Epitope-based vaccine Epitopes Evidence FIVE genomes glycoprotein highest IgG immunogenic immunoinformatics IMPROVE induce linker lung tissue membrane membrane glycoprotein MHC MHC class MHC class I MHC class II mice molecular molecular docking Multi-epitope vaccine Mutation neutralize Neutralizing Neutralizing antibodies neutralizing antibody novel Novel coronavirus omicron outbreak pandemic peptide peptides Proteins recognize reported required S1 and S2 S2 domain SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 variant SARS-CoV-2 variants selected sequence sequences spike Spike surface glycoprotein, Immunogenic, Neutralizing antibody. Spread step subunit Subunit vaccine Surface glycoprotein surface protein surface proteins T-cell T-cell epitope T-cell epitopes the vaccine Vaccine vaccine construct variant variants variants of SARS-CoV-2 Vero Cell viral surface virus virus replication wild type wild-type virus [DOI] 10.1007/s00253-022-11988-x PMC 바로가기 [Article Type] Article
High-resolution analysis of long-term serum antibodies in humans following convalescence of SARS-CoV-2 infectionSARS-CoV-2 감염 회복 후 인간의 장기 혈청 항체에 대한 고해상도 분석Article Published on 2022-05-312022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단, 치료법, [키워드] Accuracy aligned Analysis antibody Antibody Response antibody tests Antibody titer Antibody titers binding site Biomarker Blood Complete contribute convalescent serum COVID-19 diagnostic Diagnostic accuracy domain dominant epitope epitope Epitopes evaluated full-length full-length spike protein high-density Human identify Immunity Infection maintenance membrane protein neutralize nucleoprotein peptide peptide microarray polyclonal antibodies polyclonal antibody Previous studies previous study proteome provide reactivity Region representing resolved response SARS-CoV-2 SARS-COV-2 infection serological serum antibodies serum antibody spike epitope spike epitopes Spike protein Viral [DOI] 10.1038/s41598-022-12032-8 PMC 바로가기 [Article Type] Article
IgG targeting distinct seasonal coronavirus- conserved SARS-CoV-2 spike subdomains correlates with differential COVID-19 disease outcomes뚜렷한 계절성 코로나바이러스-보존 SARS-CoV-2 스파이크 하위 도메인을 표적으로 하는 IgG는 차별적인 COVID-19 질병 결과와 상관관계가 있습니다Article Published on 2022-05-312022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] Activation ADE amplification anti-Spike IgG anti-spike IgG levels anti-spike IgG response Anti-spike IgG responses antibody antibody-mediated effector responses Betacoronavirus betacoronaviruses caused conserved convalescent individual coronavirus COVID-19 COVID-19 disease COVID-19 patient COVID-19 severity CoVs CP: Immunology CP: Microbiology cross-reactivity Deleterious disease disease severity Early detection epitope Epitopes Fc-gamma receptor activation FcγR fusion protein fusion protein region greater heptad repeat heptad repeat region human betacoronavirus human betacoronavirus. humoral IgG IgG responses immunodominant epitope immunology lowest memory response Microbiology observé OC43 offer outcome predict profile Protective recall receptor responses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS1 seasonal coronaviruses severe COVID-19 patient severe COVID-19 patients severe disease significantly Spectrum Spike protein the SARS-CoV-2 virus β-CoVs [DOI] 10.1016/j.celrep.2022.110904 PMC 바로가기 [Article Type] Article
CAVES: A Novel Tool for Comparative Analysis of Variant Epitope SequencesCAVES: 변이 에피토프 서열의 비교 분석을 위한 새로운 도구Article Published on 2022-05-262022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] Accuracy Analysis antigenic antigenic variation approach bioinformatics categories category coding Comparative Comparative analysis Comparative genomics comparison Computational biology database epitope Epitope prediction Epitopes Evolution fraction Github graphical user interface IEDB immune IMPROVE novel open-source software pathogen Pathogens peptide peptides reducing required SARS-CoV-2 variant SARS-CoV-2 variants sequence Sequence analysis source code speed subject test dataset therapeutic user interface Vaccine variant window [DOI] 10.3390/v14061152 PMC 바로가기 [Article Type] Article
An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses공통 CDRH3 모티프를 가진 항체 클래스는 사베코바이러스를 광범위하게 중화합니다Article Published on 2022-05-252022-09-12 Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Analysis antibody breadth caused CDRH3 Cluster Comparative conserved coronavirus defined domain epitope Human monoclonal antibody in vitro in vivo motif neutralize neutralized observation outbreak pandemic related virus sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 suggested tested the RBD Vaccine zoonotic [DOI] 10.1126/scitranslmed.abn6859 PMC 바로가기 [Article Type] Article
Autoimmune Effect of Antibodies against the SARS-CoV-2 NucleoproteinSARS-CoV-2 핵단백질에 대한 항체의 자가면역 효과Article Published on 2022-05-252022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] Affect Analysis analyzed antibodies antibody Antibody Response Antibody titer autoantibodies autoantibody Autoimmune autoimmune reactions Autoimmunity caused complications conformational Consequences contribute coronavirus Coronavirus infection correlation correlations Course COVID-19 COVID-19 symptoms Cross reactivity debate deteriorate disease severity Effect ELISA epitope Epitopes HLA HLA allele HLA alleles human protein human proteins IgG antibodies IgG antibody induce life linear New nucleocapsid protein nucleoprotein patients with COVID-19 performed SARS-CoV-2 severity shown Spread strain susceptible Symptoms target the antibody response the disease the SARS-CoV-2 Vaccine Viral protein Viral proteins western blot [DOI] 10.3390/v14061141 PMC 바로가기 [Article Type] Article
Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopesArticle Published on 2022-05-252022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] adaptive analyses antibodies antibody antigenic structure binding binding site breadth cause circulating common cold virus conformational change coronavirus domain Endemic epitope Evolution glycoprotein Human human coronavirus OC43 Immunity in-depth analysis Infection infections Neutralizing Neutralizing antibodies neutralizing antibody neutralizing epitope non-neutralizing antibody OC43 persist prefusion S Prevent protective immunity reactive Respiratory disease reveal SARS-CoV-2 subject sustained trimer variants Viral immune evasion while [DOI] 10.1038/s41467-022-30658-0 PMC 바로가기 [Article Type] Article