The genetic architecture of helminth-specific immune responses in a wild population of Soay sheep ( Ovis aries )Soay 양의 야생 개체군에서 기생충 특이적 면역 반응의 유전적 구조( Ovis aries )Research Article Published on 2019-11-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Adults Affect antibody antibody level antibody levels blood plasma chromosome CIITA class CLEC16A collected complex condition conditions Containing contribute driver Drivers ecological Effect Evidence evidence of Genetic genetic architecture genetic control Genetic variation genomic region heritable variation histocompatibility Host hosts humans identify IgA IgA level IgA levels IgE IgG IgG antibodies IgG antibody IgG level IgG levels IGH immune Immune profile immune response immune responses Immunity Immunoglobulin immunological Infection influence investigated knowledge Laboratory lectin loci maintain Major major histocompatibility complex MHC natural populations natural selection nematodes offer Organisms Ovis parasite parasites Population prevalent provide response sheep significantly the major histocompatibility traits understanding Variation while [DOI] 10.1371/journal.pgen.1008461 PMC 바로가기 [Article Type] Research Article
Viral quasispecies바이러스 유사종Topic Page Published on 2019-10-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive adopted Antiviral classical competition complex consensus sequence consensus sequences Crossing deep sequencing defined distribution distributions Frequency Genetic variation Genome high mutation rate high mutation rates in viral information Interpretation leads lethal mutagenesis life limit methodology Mutagenesis mutant mutant clouds mutant spectra mutant swarm mutant swarms mutants Mutation mutation rate Mutation rates pathogen Pathogens populations present day provided Quasispecies quasispecy relative frequency Replication RNA virus RNA viruses Standard clonal analyses Standard clonal analysis theory transition unit variant Viral Viral quasispecies viral replication Virology viruses wild type [DOI] 10.1371/journal.pgen.1008271 PMC 바로가기 [Article Type] Topic Page
Genetic variation in FCER1A predicts peginterferon alfa-2a-induced hepatitis B surface antigen clearance in East Asian patients with chronic hepatitis BClinical Trial Published on 2019-09-012023-06-18 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] Chronic Hepatitis B Genetic variation peginterferon alfa-2a response [DOI] 10.1111/jvh.13107 [Article Type] Clinical Trial
Genetic determinants of gut microbiota composition and bile acid profiles in mice생쥐의 장내 미생물 조성 및 담즙산 프로필의 유전적 결정인자Research Article Published on 2019-08-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abundance Analysis approach Author Bacterial bile acid bile acids can be used changes in characterized cholic acid distal Diversity Effects eight environmental cue environmental cues experiment fecal Follow-up Gene Expression generate Genetic genetic determinant genetic differences Genetic variant genetic variants Genetic variation genetics Genome genomic region genotypic data Gut gut bacteria gut microbiota composition homeostasis hormone Hormones Host host genetics Human hypothese Hypothesis ileal influence Inter-individual variation Interaction interactions intestinal loci locus mammal mapped mechanism mediation Mediation analysis metabolism metabolites mice microbes Microbial communities microbial community microbiota overlapping plasma produced profile profiles QTL Quantitative quantitative trait locus Slc10a2 strain Strains subsequent sucrose Variation variations while [DOI] 10.1371/journal.pgen.1008073 PMC 바로가기 [Article Type] Research Article
Analysis of genetic and serology of hepatitis A virus infection during and after outbreak in two junior high schools in Surabaya, IndonesiaArticle Published on 2019-06-012023-05-31 Journal: Journal of medical virology [Category] A형 간염, [키워드] Genetic variation hepatitis A virus Immunoglobulin [DOI] 10.1002/jmv.25403
Genetic Characterization of Middle East Respiratory Syndrome Coronavirus, South Korea, 2018Dispatch Published on 2019-05-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] S gene Caco-2 cells characterization coronavirus evaluated Genetic variation isolate MERS-CoV Middle East Middle East respiratory syndrome Patient respiratory respiratory syndrome coronavirus Saudi Arabia South Korea specimen spike gene sputum throat swab viruses [DOI] 10.3201/eid2505.181534 PMC 바로가기 [Article Type] Dispatch
Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremiaGLS2의 인간 유전적 변이는 복잡한 황색 포도구균 균혈증의 발병과 관련이 있습니다Research Article Published on 2018-10-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate age allele Analysis association Bacteremia Bacteria Bacterial Blood cells bloodstream Bonferroni correction candidate gene capture cause causes Cell coding variant complex Complication Control correlated CRISPR CRISPR-Cas9 cumulative cumulative effect death eight ENCODE evaluated examined exhibited Exome expression expression level Factor Frequency gene-based analysis gene-expression Genetic genetic factors genetic risk factor Genetic variant genetic variants Genetic variation Genome GLS2 Glutamine growth healthy controls Hospitalization Host Human Human genome immune response individual Infection infections Interaction key factor leukocyte leukocyte activation Logistic regression analysis Macrophage macrophage cells metabolism Microarray missense variant nitric oxide plasma concentration Protein regulate Regulatory Replication risk S . aureus sequence Sequencing Sex significantly significantly lower Staphylococcus aureus susceptible the strongest These cells Transcription variant variants Variation variations WES White blood cell White blood cells wild-type cells [DOI] 10.1371/journal.pgen.1007667 PMC 바로가기 [Article Type] Research Article
Genetic diversity and population structure of Anopheles triannulatus s. l. in the department of Córdoba, Colombia, using DNA barcodingArticle Published on 2018-08-012024-08-28 Journal: Biomédica [Category] 말라리아, [키워드] Anopheles/genetics Colombia gene flow. Genetic variation haplotypes
Genetic ancestry and population differences in levels of inflammatory cytokines in women: Role for evolutionary selection and environmental factors여성의 염증성 사이토카인 수치의 유전적 조상과 집단 차이: 진화적 선택과 환경적 요인의 역할Research Article Published on 2018-06-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulated adaptive African age alcohol allele Analysis ancestry Antigen antigen receptor Blood cells CCL11 CCL2 chemokine chemokines chronic inflammation circulating circulating cytokines cytokine Cytokines Diseases Endemic environmental factor eosinophils European examined explain exposure to Factor Factors finding gene encoding Genetic genetic difference genetic differences Genetic variant Genetic variation Health Human human immunity IFNα2 IL10 IL1RA IL4 immune immune response immune response genes immune system Immunity implicated implication individual Infection Inflammation Inflammatory Inflammatory cytokine innate and adaptive immunity involved Level living environment living environments Local malaria Migration molecular monocyte Monocytes obesity occur Part pathogen Pathogens phenotypic variance plasma Plasma levels populations pro-inflammatory Protein receptor protein red blood cells Regulation role Selection selection pressure signal significant difference significant differences smoking susceptibility systemic level thought variant Variation White blood cells women [DOI] 10.1371/journal.pgen.1007368 PMC 바로가기 [Article Type] Research Article
Oseltamivir-resistant influenza A(H1N1)pdm09 virus associated with high case fatality, India 2015Article Published on 2018-05-012023-06-23 Journal: Journal of medical virology [Category] 신종인플루엔자, [키워드] Genetic variation Influenza virus Mutation/mutation rate neuraminidase inhibitor pandemics, resistance. [DOI] 10.1002/jmv.25013