The Post-Acute Phase of SARS-CoV-2 Infection in Two Macaque Species Is Associated with Signs of Ongoing Virus Replication and Pathology in Pulmonary and Extrapulmonary Tissues두 개의 원숭이 종에서 SARS-COV-2 감염의 급성기 후에는 폐 및 외부 조직에서 진행중인 바이러스 복제 및 병리의 징후와 관련이 있습니다.Article Published on 2021-08-232022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] activated acute phase animal models Computed tomography Conjunctiva consequence COVID-19 cynomolgus macaque cynomolgus macaques detectable Extrapulmonary extrapulmonary tissue feces heart histological Histopathology humans immune activation Infection investigated lesion lung lung tissue Lungs Lymph node lymph nodes macaque macaques Messenger RNA necropsy NHPs non-human primates nose nose and throat phase positron emission Positron emission tomography pulmonary pulmonary lesion pulmonary lesions respiratory respiratory tract rhesus salivary salivary gland SARS-CoV-2 SARS-COV-2 infection SIGN Specy tissue sample tissue samples tomography tracheobronchial tracheobronchial lymph nodes Viral Viral RNA virus replication [DOI] 10.3390/v13081673 PMC 바로가기 [Article Type] Article
Complete Heart Block as a Clinical Feature in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients: A Case Series of Three CasesCase Series Published on 2021-08-112022-10-31 Journal: Case Reports in Critical Care [Category] COVID-19, [키워드] 24 hours block case sery cause CHB clinical Clinical characteristics Complete heart block coronary syndrome COVID-19 COVID-19 patient COVID-19 patients Critically ill diagnosed with COVID-19 disease exhibited Familial heart hemodynamic hemodynamic instability hypoxic respiratory failure Ill include infiltration intubation Lower male mechanical ventilator metabolic derangement morbidity and mortality multiorgan failure Myocardial inflammation novel outcome past medical history patients with COVID-19 potential mechanism potential mechanisms pregnant required resolved Section Sery Severe COVID-19 pneumonia Shock sinus pause Support with COVID-19 [DOI] 10.1155/2021/9955466 PMC 바로가기 [Article Type] Case Series
COVID-19 and Heart Failure: From Epidemiology During the Pandemic to Myocardial Injury, Myocarditis, and Heart Failure SequelaeCardiovascular Medicine Published on 2021-08-102022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] acute phase available data catastrophic Clinical course Comorbidities complications coronavirus disease country COVID-19 COVID-19 case COVID-19 pandemic COVID-19 patient Critically ill patient described develop diastolic echocardiographic Ejection fraction Epidemiology failure global public health health system heart heart failure histopathological findings hospitalizations impairment in-hospital mortality increase in independent Injury investigated LV dysfunction Mortality myocardial injury myocarditis occurred pathophysiology patients hospitalized potential mechanism presenting pulmonary hypertension reduction in representing risk factor SARS-COV-2 infection second subsequent suggested ventricular ventricular dysfunction [DOI] 10.3389/fcvm.2021.713560 PMC 바로가기 [Article Type] Cardiovascular Medicine
Impact of cancer and cardiovascular disease on in-hospital outcomes of COVID-19 patients: results from the american heart association COVID-19 cardiovascular disease registryResearch Published on 2021-08-102022-10-31 Journal: Cardio-oncology [Category] COVID-19, [키워드] 95% confidence interval adjusted adjusted odds ratio Admission age analyzed appear association average BMI body mass index Cancer cancer patient Cancer patients Cancer therapy cardiovascular disease Chemotherapy COVID-19 CVD demographics demonstrated died distribution enrolled evaluate the effect heart history hospital Hospitalized hospitalized COVID-19 patients Impact implication In-hospital In-hospital death in-hospital mortality increased mortality logistic regression model malignancy Mortality outcome Patient patients Primary outcome registry Result risk factor Risk factors severe disease significant interaction significantly smoking statistically survival symptomatic adult tested thromboembolic disease Vaccine while with COVID-19 [DOI] 10.1186/s40959-021-00113-y PMC 바로가기 [Article Type] Research
Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID-19 TherapeuticsPharmacology Published on 2021-08-042022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] arrhythmia Arrhythmias Azithromycin cardiac Cardiomyocytes Clinical findings clinical measurement clinical trial clinically clinician Combination combined efficacy COVID-19 debate drug drug response Drug screening drugs effective effective drugs effort Emergency use authorization evaluate events Evidence FDA Frequency global efforts HCQ heart heart muscle Hospitalization hospitalized COVID-19 patients Hydroxychloroquine identify increase in induced pluripotent stem cells Microphysiological systems MPS muscle platform pluripotent stem cell polytherapy predict predicted prediction Premature QT interval QT prolongation reflected resource Safe SARS-CoV-2 SARS-CoV-2 pandemic significant increase System Therapeutics time-consuming tissue treat treated treatment for COVID-19 was measured while worsening [DOI] 10.3389/fphar.2021.684252 PMC 바로가기 [Article Type] Pharmacology
Non-communicable disease, sociodemographic factors, and risk of death from infection: a UK Biobank observational cohort studyObservational Study Published on 2021-08-012022-10-04 Journal: The Lancet. Infectious Diseases [Category] MERS, SARS, 임상, [키워드] 95% CI 95% CIs accompanied Advancing age Analysis Asian association Autoimmune black body-mass Cancer cause chronic heart disease Chronic kidney disease chronic liver disease chronic respiratory disease Cohort Comorbidities Comorbidity COVID-19 mortality COVID-19 pandemic death diabetes disease effective excluded exclusion Factor finding FIVE Follow-up foundation funding greater groups heart hypertension incidence rate increased risk individuals Infection Infectious disease Inflammatory Male sex median Mortality Multimorbidity Neurological disease non-specific obesity Observational cohort study occurred outcome measure participant Poisson regression model prevalent Psychiatric psychiatric disorder recruitment reduced risk repeated replaced reported Research Respiratory disease rheumatological risk factor risk of death risk of infection Separate Sex smoking smoking status sociodemographic factors Socioeconomic deprivation stroke subset to define UK biobank used data white with COVID-19 [DOI] 10.1016/S1473-3099(20)30978-6 PMC 바로가기 [Article Type] Observational Study
Cardiac involvement in MRI in young population after COVID-19: A single tertiary center experienceCOVID-19 이후 젊은 인구에서 MRI의 심장 침범: 단일 3차 센터 경험Article Published on 2021-08-012022-09-11 Journal: Echocardiography (Mount Kisco, N.Y.) [Category] SARS, 치료기술, [키워드] Affect age analyzed Asymptomatic broad spectrum cardiac cardiac involvement cardiac MR cause Chain Reaction Chest chest pain chronic disease Chronic diseases consecutive patient COVID 19 COVID-19 Dyspnea Ejection fraction evaluate heart Infection influence Mild morbidity morbidity and mortality MRI myocardial injury myocardial involvement myocarditis organs Patient patients polymerase chain polymerase chain reaction Prevalence problem Respiratory system reverse transcription reverse transcription polymerase chain reaction RT-PCR Side effect significantly lower single center statistically statistically significant stroke Stroke volume symptomatic patient Symptomatic patients Symptoms TAPSE tricuspid Volume widespread with COVID-19 [DOI] 10.1111/echo.15160 PMC 바로가기 [Article Type] Article
Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trialCovid-19 (Colcorona)를 가진 지역 사회 치료 환자를위한 콜히친 : 3 단계, 무작위, 이중 맹검, 적응 형, 위약 대조, 다중 센터 시험Clinical Trial Published on 2021-08-012022-08-13 Journal: The Lancet. Respiratory Medicine [Category] MERS, SARS, 임상, [키워드] 1:1 absence adaptive adverse event allocation sequence Analysis anti-inflammatory agent assigned automated automated interactive web-response system benefit block size block sizes blocking schema Brazil Canada clinical criteria Colchicine colchicine group COLCORONA trial community-treated patient community-treated patients complications Composite computer-generated coronary disease COVID-19 COVID-19 complication COVID-19 complications COVID-19-related clinical event COVID-19-related clinical events COVID-19-related death death diagnosed diagnostic test diarrhoea double-blind double-blinded eligible enrolled excessive inflammation family finding foundation funding Gout Government Greece heart high-risk characteristic hospital Hospital admission intention-to-treat principle interactive web-response system IQR mandatory diagnostic test masked randomisation matching placebo median age Medicine Melinda Gate Melinda Gates Montreal Heart Institute multicentre occurred Odds ratio oral anti-inflammatory medication orally administered colchicine orally administered therapies orally administered therapy Participants Patient patients PCR testing PCR-confirmed PCR-confirmed COVID-19 PCR-positive community-treated patient PCR-positive community-treated patients per day Pericarditis Phase 3 Placebo placebo group placebo-controlled Pneumonia Prevent primary efficacy endpoint primary endpoint randomisation list randomised Randomly receive Registered Replication reported risk Safe School Serious Adverse Events Sophie South Africa Spain statistically significant the placebo group the primary endpoint treated Trial trial enrolment unmasked biostatistician USA Vital vital status was done with COVID-19 [DOI] 10.1016/S2213-2600(21)00222-8 PMC 바로가기 [Article Type] Clinical Trial
The lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID19 viruses코로나바이러스의 치명적인 내부 얼굴: SARS, MERS 및 COVID19 바이러스의 신장 친화성Review Published on 2021-08-012022-09-11 Journal: Iubmb Life [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] 2019-nCoV ACE2 acute respiratory distress acute respiratory distress syndrome ARDS attacked cause Cell cells characterized Complication coronavirus Coronavirus infection CoV infection COVID19 damages distal DPP4 failure functions heart humans induce infected patients infecting infective kidney kidney tissue knowledge liver mechanism MERS MERS-CoV MERS-CoV infection mortality rate Novel coronavirus organ outbreak pandemic pathology Patient Proteinuria provided receptor renal dysfunction renal failure renal impairment respiratory distress Respiratory distress syndrome SARS SARS-CoV SARS-CoV-2 syndrome target triggered viral infection viral invasion virus [DOI] 10.1002/iub.2516 PMC 바로가기 [Article Type] Review
Early detection of COVID-19 in the UK using self-reported symptoms: a large-scale, prospective, epidemiological surveillance study자가 보고 증상을 이용한 영국의 COVID-19 조기 발견: 대규모, 전향적, 역학 감시 연구Observational Study Published on 2021-07-292022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 임상, 치료기술, [키워드] age Algorithm artificial intelligence AUC body-mass body-mass index changes in characteristic chronic chronic disease clinical information Comorbidities Council COVID-19 COVID-19 pandemic COVID-19 PCR test COVID-19 symptoms Department detect Early detection Engineering epidemiological epidemiological surveillance evaluated feasible feature finding foci foundation funding health-care heart Hierarchical identify individual infected with SARS-CoV-2 Infection Logistic regression logistic regression model Massachusett Medical Research Council Medical resources mobile phone Model National Health Service NHS Older pandemic participant Participants PCR test populations predict Probability readiness receiver operating characteristic receiver operating characteristic curve reported symptom robust SARS-COV-2 infection Science Self-isolation self-reported symptom Self-reported symptoms sensitivity Sex significantly higher Society specificity spread of COVID-19 stratified study population subgroup subgroups Surveillance Symptom Symptoms symptoms onset test results training set variable Wellcome Trust [DOI] 10.1016/S2589-7500(21)00131-X PMC 바로가기 [Article Type] Observational Study