homologous – Page 18 – Communicable Diseases Research

Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease

SARS-CoV-2 주요 프로테아제에 의한 다양한 바이러스 기질의 인식

Article

Published on 2021-09-102022-09-11
Journal: ACS Infectious Diseases [Category] Coronavirus, SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acid substitution amino acid substitutions antiviral drug catalysis catalytic changes in cleavage cleavage site cleave conserved coronavirus coronavirus disease Coronaviruses COVID-19 crystal structure crystal structures Efficiency ENhance homologous junction lifecycle M pro MPro NSP8 parameters peptide peptides polyprotein protease Proteases provide Recognition recognize Replication residue SARS-CoV-2 severe acute respiratory syndrome Coronavirus Structure structures substrate the SARS-CoV-2 unique viral nonstructural protein viral nonstructural proteins viral replication Virology Visualization
[DOI] 10.1021/acsinfecdis.1c00237 PMC 바로가기 [Article Type] Article

Modelling the active SARS-CoV-2 helicase complex as a basis for structure-based inhibitor design †

Chemistry

Published on 2021-09-062022-10-31
Journal: Chemical Science [Category] COVID-19,

Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial

아데노바이러스 벡터화 및 mRNA COVID-19 백신(Com-COV)을 사용한 이종 대 상동 프라임-부스트 일정의 안전성 및 면역원성: 단일 맹검, 무작위, 비열등성 시험

Clinical Trial

Published on 2021-09-042022-09-11
Journal: Lancet (London, England) [Category] Fulltext, MERS, 임상, 진단,

[키워드] (ChAdOx1 nCoV-19 Administered age anti-Spike IgG approved assigned AstraZeneca baseline blood test blood tests BNT BNT162b2 boost ChAd ChAdOx1 ChAdOx1 nCoV-19 Cohort Comorbidity comparison Concentration COVID-19 COVID-19 disease COVID-19 vaccine COVID-19 vaccines criteria dose Efficacy eight eligible eligible participant Eligible participants ELISA enrolled evaluate facilitate female participant force geometric mean geometric mean concentration geometric mean ratio GMR greater groups Heterologous heterologous prime-boost heterologous schedule heterologous schedules homologous homologous schedule hospitalisation immune immune responses immunisation immunogenicity immunology inferiority ISRCTN laboratory confirmation limit majority mRNA mRNA vaccine non-inferiority non-inferiority trial occurred Older participant per-protocol population Pfizer-BioNTech primary analysis primary endpoint prime-boost interval prime-boost intervals randomised Randomly reactogenic reactogenicity receive receiving recipient recruited referred to regimen Registered reported Safety safety analyses safety analysis SARS-CoV-2 anti-spike IgG SARS-COV-2 infection Serious Adverse Event seronegative serum single-blind subset Support Task Force the SARS-CoV-2 the vaccine These data Trial vaccination Vaccine Vaccines vectored vaccine was done
[DOI] 10.1016/S0140-6736(21)01694-9 PMC 바로가기 [Article Type] Clinical Trial

Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvement

COVID-19와 자가면역의 해결: 그럴듯한 표적의 식별은 다기관 관련을 시사합니다

Article

Published on 2021-09-012022-09-12
Journal: Molecular immunology [Category] MERS, SARS, 진단,

An Immunogenicity Report for the Comparison between Heterologous and Homologous Prime-Boost Schedules with ChAdOx1-S and BNT162b2 Vaccines

Article

Published on 2021-08-252022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Homology between SARS CoV-2 and human proteins

Article

Published on 2021-08-252022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,

Neutralization of the SARS-CoV-2 Delta variant after heterologous and homologous BNT162b2 or ChAdOx1 nCoV-19 vaccination

이종 및 동종 BNT162b2 또는 ChAdOx1 nCoV-19 백신 접종 후 SARS-CoV-2 Delta 변이체 중화

Correspondence

Published on 2021-08-232022-09-11
Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 변종,

[키워드] antibodies BNT162b2 ChAdOx1 nCoV-19 delta variant Heterologous homologous the SARS-CoV-2 vaccination Vaccines
[DOI] 10.1038/s41423-021-00755-z PMC 바로가기 [Article Type] Correspondence

Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people

Research

Published on 2021-08-202022-10-30
Journal: Immunity & Ageing : I & A [Category] COVID-19,

[키워드] adenovirus vaccine adenovirus-based Analysis antibody Antibody Response Antibody titre blood sample BNT162b2 BNT162b2 mRNA boost cellular Cellular immune response cellular response ChAdOx1 ChAdOx1 vaccine Clinical efficacy clinical risk COVID detectable Donor electrochemiluminescence immunoassay elicited Evidence extended interval extended-interval heterologous vaccine homologous Homologous vaccine Humoral immunity IFN-γ ELISPOT immune response immune senescence induce Infection IQR limit median Meta-analysis mRNA natural infection objective of BNT162b2 offer Older participant Patient platform protocol question recipient regimen regimens reported response Result SARS-CoV-2 SARS-CoV-2 vaccine second dose shown Spike protein Spike-specific antibody stability supplementary material T cell response the median vaccination Vaccine vaccine responses vaccinee were assessed were measured
[DOI] 10.1186/s12979-021-00246-9 PMC 바로가기 [Article Type] Research

Detection of SARS-CoV-2 Derived Small RNAs and Changes in Circulating Small RNAs Associated with COVID-19

SARS-COV-2 유도 된 작은 RNA의 검출 및 COVID-19와 관련된 순환 소형 RNA의 변화

Brief Report

Published on 2021-08-112022-09-10
Journal: Viruses [Category] MERS, SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제,

[키워드] Ageusia Analysis candidate gene change circulating circulating-miRNA cleavage conserved convalescent COVID-19 patient COVID COVID-19 cytokine Cytokine storm Defense defense mechanism described detectable detection double-stranded RNA events homologous Host host defense human miRNA human miRNAs immune response immune responses Jak-STAT Long COVID mechanism Mild miRNA miRNAs NSP2 nsp4 plasma plasma sample plasma samples product reduced RNA sequence RNAs SARS-CoV-2 sequence Sequencing severe cases severe COVID-19 siRNA small RNA Small RNAs STAT Symptoms the disease transcriptional gene silencing Trigger triggers Viral viral infection virus with COVID-19
[DOI] 10.3390/v13081593 PMC 바로가기 [Article Type] Brief Report

BCG Vaccine Derived Peptides Induce SARS-CoV-2 T Cell Cross-Reactivity

Immunology

Published on 2021-08-052022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,