COVID-19 hospital admissions and deaths after BNT162b2 and ChAdOx1 nCoV-19 vaccinations in 2·57 million people in Scotland (EAVE II): a prospective cohort studyBNT162B2 및 Chadox1 NCOV-19 백신 접종 후 COVID-19 병원 입원 및 사망 (EAVE II) : 전향 적 코호트 연구Articles Published on 2021-12-012022-09-06 Journal: The Lancet. Respiratory Medicine [Category] Communicable Disease, COVID-19, Fulltext, SARS, [키워드] (Medical Research Council) 95% CI adjusted Admission Analysis BNT162b2 Care ChAdOx1 ChAdOx1 nCoV-19 challenge clinical factor clinical feature Comorbidities Comorbidity conducted COVID-19 COVID-19 hospitalisation COVID-19 illness COVID-19 mortality COVID-19 test COVID-19 vaccination programme COVID-19 vaccine death died enhanced estimate rate ratio finding first dose FIVE Frequency funding group Health Data Research UK help highest hospital Hospital admission hospitalisation hospitalised incidence individual individuals Industrial Innovation less male management Medical Research Council Mortality National Older age outcome pandemic Pfizer Pfizer–BioNTech platform Poisson regression model primary care prioritised vaccination prospective cohort study Protective rate ratios receiving risk risk of COVID-19 RRs RT-PCR testing SARS-COV-2 infection Scottish severe COVID-19 severe disease Social distancing measure social distancing measures Socioeconomic deprivation Strategy stratified study period Surveillance time-dependent Poisson regression model unvaccinated population unvaccinated populations vaccination Vaccine vaccine dose with COVID-19 [DOI] 10.1016/S2213-2600(21)00380-5 PMC 바로가기 [Article Type] Articles
Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial입원한 성인 COVID-19(COV-BARRIER) 치료를 위한 바리시티닙의 효능 및 안전성: 무작위, 이중 맹검, 병행군, 위약 대조 3상 시험Clinical Trial Published on 2021-12-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, SARS, 임상, 치료법, 치료제, [키워드] 1:1 95% CI Abstract addition all-cause mortality anti-inflammatory properties antivirals Asia assigned available data Baricitinib baseline Care Combination company Corticosteroids country death defined Dexamethasone Disease progression dose double-blind Efficacy and safety enrolled Europe evaluate event exploratory Follow-up French frequencies Frequency hazard ratio High-flow oxygen hospitalised inhibitor intention-to-treat population Invasive mechanical ventilation Janus kinase Japanese Lilly material Mortality non-invasive ventilation North America Odds ratio oxygen parallel-group participant Participants Phase 3 phase 3 trial Placebo placebo group placebo-controlled placebo-controlled trial prevented primary endpoint progressed proportion randomised Randomly receive receiving reduced reduction in Registered Remdesivir risk risk difference safety analyses safety analysis safety population safety profile secondary endpoint selective Serious Adverse Event Serious Adverse Events serious infection serious infections South America Spanish Standard Standard of care study drug systemic corticosteroid systemic corticosteroids the placebo group the primary endpoint thromboembolic translation Treatment two groups venous thromboembolic were assessed with COVID-19 [DOI] 10.1016/S2213-2600(21)00331-3 PMC 바로가기 [Article Type] Clinical Trial
Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trialCovid-19 (회복)로 병원에 입원 한 환자의 콜히친 : 무작위, 통제, 오픈 라벨, 플랫폼 시험Randomized Controlled Trial Published on 2021-12-012022-08-13 Journal: The Lancet. Respiratory Medicine [Category] MERS, SARS, 임상, [키워드] (Medical Research Council) 1:1 28-day mortality allocation concealment Analysis anti-inflammatory actions assigned baseline both groups by mouth clinically suspected clinician Colchicine colchicine 1 mg colchicine group composite endpoint CYP3A4 CYP3A4 inhibitor death died Diltiazem discharge discharged Efficacy and safety eligible enrolled estimated glomerular filtration rate evaluate filtration rate finding followed by for inclusion Frequency funding glomerular filtration rate had no hospital Hospital stay hospitalised hospitals in Indonesia hospitals in Nepal in both groups Indonesia Innovation Intention intention-to-treat Invasive mechanical ventilation ISRCTN Laboratory less medical history Medical Research Council moderate nasogastric tube Nepal no significant difference Open-label open-label trial opinion participant Patient Platform trial Primary outcome proportion randomisation randomised Randomly rate ratio receive receiving RECOVERY trial reductions reductions in Registered risk risk ratio SARS-COV-2 infection secondary endpoint Secondary endpoints significant difference Standard of care subgroups of patients the patient Treatment treatment for COVID-19 Trial twice a day usual care usual care group web-based simple Wellcome Trust with COVID-19 [DOI] 10.1016/S2213-2600(21)00435-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
SARS-CoV-2 in children with cancer or after haematopoietic stem cell transplant: An analysis of 131 patientsObservational Study Published on 2021-12-012022-10-05 Journal: European journal of cancer (Oxford, England : 1990 [Category] 임상, 치료기술, [키워드] 95% CI 95% confidence interval Analysis Asymptomatic baseline Cancer Care Cell Chemotherapy Child children clinical variable Comorbidity cough country COVID-19 COVID-19 symptoms Critical detectable determine died disease disease severity Factor FIVE full recovery haematopoietic stem cell transplantation help hospitalised HSCT identify immunodeficiency Infection intensive care management median median age Mild moderate neutropenia Odds ratio organ support outcome Patient patients patients with COVID-19 polymerase chain required risk SARS-CoV-2 severe COVID-19 severe disease severity significantly solid tumour Symptoms virus was used [DOI] 10.1016/j.ejca.2021.09.027 PMC 바로가기 [Article Type] Observational Study
Acute estradiol and progesterone therapy in hospitalised adults to reduce COVID-19 severity: a randomised control trialRandomized Controlled Trial Published on 2021-11-302022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] addition Admission adverse events Anti-inflammatory antibody production approved drug Biology center clinically Corticosteroids COVID-19 death determine disease severity double blind drug Efficacy Ethical approval Ethics evaluate food general endocrinology Hospital stay hospitalised Hospitalised patients HRT HRT. immune response immune tolerance include Infectious diseases Inflammatory biomarker intramuscular mechanical ventilation Medicine mitigate New New Orleans Occurrence Oestradiol outcome Participants Patient peer-reviewed Phase 2 Placebo placebo-controlled primary endpoint Primary outcome progesterone proportion randomised readmission reduce reducing Result Sample size secondary Sex sex steroids & Sponsor Standard of care steroid subjects submitted the WHO therapeutic option therapy Trial university USA was obtained WHO ordinal scale [DOI] 10.1136/bmjopen-2021-053684 PMC 바로가기 [Article Type] Randomized Controlled Trial
Factors associated with hospital and intensive care admission in paediatric SARS-CoV-2 infection: a prospective nationwide observational cohort studyObservational Study Published on 2021-11-292022-10-04 Journal: European journal of pediatrics [Category] MERS, SARS, 임상, [키워드] 95%CI Admission Adults anosmia/dysgeusia Asymptomatic cardiovascular complication Child children children with COVID-19 Clinical characteristics clinical manifestation clinical presentation collected Comorbidities Comorbidity Complication Continuous Coronavirus disease 2019 cough COVID-19 Critical disease death disease eight Epidemiology evaluate Factor female Fever headache hospital Hospital admission hospitalised ICU admission inotrope intensive care IQR less mechanical ventilation median age Mild MOST multivariable nine non-hospitalised observation Observational cohort study Odds ratio outcome Oxygen treatment pandemic preexisting comorbidity prevalent Rash regression analysis reported required SARS-CoV-2 SARS-COV-2 infection severity of COVID-19 supplementary material Switzerland Symptom therapy Transmission Treatment unit vaccination were recorded [DOI] 10.1007/s00431-021-04276-9 PMC 바로가기 [Article Type] Observational Study
Diabetes, obesity, hypertension and risk of severe COVID-19: a protocol for systematic review and meta-analysis당뇨병, 비만, 고혈압 및 심각한 Covid-19의 위험 : 체계적인 검토 및 메타 분석을위한 프로토콜Article Published on 2021-11-262022-08-31 Journal: BMJ Open [Category] MERS, meta-analysis, SARS, [키워드] Admission article association center China CINAHL clinical Clinical outcome clinical outcomes clinical trials Cochrane Library conducted COVID-19 COVID-19 collection database death diabete diabetes diabetes & endocrinology Epidemiology Ethics Evidence global health heterogeneity hospitalised hypertension include indicate intensive care intensive care unit admission International Italy item library mechanical ventilation meta-analyses Meta-analysis National non-communicable diseases obesity observational studies observational study Patient patients with COVID-19 peer-reviewed populations ProQuest PROSPERO protocol PsycINFO PubMed Central receiving registration number Reporting Research review risk risk factor security Stata statistical statistical analysis subject systematic review US CDC USA WHO [DOI] 10.1136/bmjopen-2021-051711 PMC 바로가기 [Article Type] Article
COVID-19 Impact in the Italian Reception System for Migrants during the Nationwide Lockdown: A National Observational Study전국 봉쇄 기간 동안 이탈리아 이민자 수용 시스템에 COVID-19가 미치는 영향: 국가 관찰 연구Observational Study Published on 2021-11-252022-09-10 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 임상, 치료기술, [키워드] Cluster confirmed case confirmed cases COVID-19 COVID-19 outbreak COVID-19 pandemic cumulative cumulative incidence death Europe evaluate expressed geographical distribution Health highest hospitalised hosts Impact incidence incidence of cases Italian lockdown migrant health National observation outcomes pandemic populations positive PROTECT public health raised reported Resilience saturation index South System Vulnerable populations was performed [DOI] 10.3390/ijerph182312380 PMC 바로가기 [Article Type] Observational Study
Emotional status and fear in patients scheduled for elective surgery during COVID-19 pandemic: a nationwide cross-sectional survey (COVID-SURGERY)Original Article Published on 2021-11-252022-10-30 Journal: Journal of Anesthesia, Analgesia and Critical Care [Category] COVID-19, [키워드] age anaesthesia being cardiovascular disease chronic disease Cohort Contagion COVID-19 COVID-19 pandemic cross-sectional survey disease drugs Elective surgery emotional Emotional status evaluate Factor higher risk hospital Hospital admission hospitalised Hospitalization IMPROVE increased risk Infection involved Italian Italy males multicentre outcome pandemic participant Patient patients Perioperative medicine Population Psychological distress receive reduced risk Result SARS-CoV-2 SARS-COV-2 infection supplementary material Support surgical survey the patient Volume with COVID-19 [DOI] 10.1186/s44158-021-00022-7 PMC 바로가기 [Article Type] Original Article
Comparing the first and second waves of COVID-19 in a tertiary university hospital in BarcelonaObservational Study Published on 2021-11-242022-10-05 Journal: F1000Research [Category] 신종인플루엔자, 임상, [키워드] affected analysed Analysis Barcelona Care carried change Comorbidity COVID-19 COVID-19 pandemic COVID-19 patient declined demographics dropped electronic medical record expected First wave Health Healthcare system Hebron hospital hospital management Hospital wards hospitalised hospitalised COVID-19 patient ICU Inpatient intensive care knowledge less management Mortality no significant difference pandemic Patient profiles progressed Research resource retrospective second wave severity significantly Spain tertiary hospital. the disease university university hospital [DOI] 10.12688/f1000research.73988.1 PMC 바로가기 [Article Type] Observational Study