Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagyarticle Published on 2019-11-302024-09-01 Journal: Autophagy [Category] 살모넬라증, [키워드] autophagy Bacteria Colitis HMGB1 IBD organoids STAT3 [Article Type] article
Targeting Cytokine Signaling and Lymphocyte Traffic via Small Molecules in Inflammatory Bowel Disease: JAK Inhibitors and S1PR AgonistsReview Published on 2019-03-132024-09-02 Journal: Frontiers in Pharmacology [Category] 대상포진, [키워드] IBD jak inhibitors MOA S1P agonists Small molecules [DOI] 10.3389/fphar.2019.00212 PMC 바로가기 [Article Type] Review
Genetic effects on the commensal microbiota in inflammatory bowel disease patients염증성 장질환 환자의 공생 미생물에 대한 유전적 영향Research Article Published on 2019-03-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis association associations Bacteria Bacterial case study cohorts disease risk Effect etiology Evidence Faecalibacterium fitness Genetic genetic susceptibility Genetic variant Genome-wide association studies gut microbiota Host host genetics IBD increased risk independent Inflammatory bowel disease Microbiome microbiota NOD2 Observational data Patient performed potential mechanism replicated resulting reverse causation risk risk allele robustness Sensitivity analyses sensitivity analysis shown significantly Simulation study Study design the disease variant [DOI] 10.1371/journal.pgen.1008018 PMC 바로가기 [Article Type] Research Article
Reduced monocyte and macrophage TNFSF15 /TL1A expression is associated with susceptibility to inflammatory bowel disease감소된 단핵구 및 대식세포 TNFSF15 /TL1A 발현은 염증성 장 질환에 대한 감수성과 관련이 있습니다Research Article Published on 2018-09-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition Affect allele animal model animal models association assumption bowel breakdown cell type cell types characterized chronic chronic inflammation compromise condition contribute Crohn’s disease cytokine decreased expression determine disease disease risk ENCODE ENhance Ethnic groups Evidence expression expression measurement functional genetic change genetic loci Genetic variant Genome-wide association studies Genotype Gut Haplotype healthy volunteer Hypothesis IBD IBD loci Immune homeostasis immunopathology increase Inflammation Inflammatory bowel disease intestinal list locus lymphocyte Macrophage macrophage differentiation macrophages mechanism monocyte Monocytes murine model murine models over patients Peripheral blood peripheral blood monocytes persist polymorphism Polymorphisms predisposition pro-inflammatory promote protective role protein level protein levels question receptor regulated regulatory region required responsible risk risk allele RNA shown Signaling Stimulation subtype susceptibility T cell T cells TNF TNFSF15 ulcerative colitis upstream variant variety [DOI] 10.1371/journal.pgen.1007458 PMC 바로가기 [Article Type] Research Article
Identity-by-descent analyses for measuring population dynamics and selection in recombining pathogens재결합 병원체에서 개체군 역학 및 선택을 측정하기 위한 혈통별 식별 분석Research Article Published on 2018-05-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] added addition Analysis antimalarial antimalarial drug Artemisinin Asia can be used clonal expansion comparison Comparisons country Critical critical regions dataset descent determine disease disease control disease transmission Diseases distributions drug resistance Efficacy effort evaluate events Exploratory analysis gene flow genetic diversity genetic study Genome genomes genomic genomic data genomic region Haplotype IBD identification identify independent infections Infectious disease Infectious diseases isolate isolates lack loci malaria methodology microorganism microorganisms multiple infections natural selection Organisms overlap pathogen Pathogens Plasmodium Plasmodium falciparum population bottleneck population bottlenecks populations Positive selection reduced regions selected selection pressure sequencing data Spread statistical methodologies statistical methodology statistical model Transmission Treatment whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1007279 PMC 바로가기 [Article Type] Research Article
Multifunctional Role of 35 Kilodalton Hyaluronan in Promoting Defense of the Intestinal Epitheliumarticle Published on 2018-04-302024-09-01 Journal: Journal of Histochemistry & Cytochemistry [Category] 살모넬라증, [키워드] claudin-2 defensin Hyaluronan IBD Inflammatory bowel disease Salmonella Typhimurium [Article Type] article
New treatment options for inflammatory bowel diseasesReview Published on 2018-03-192024-09-02 Journal: Journal of Gastroenterology [Category] 대상포진, [키워드] anti-adhesion Anti-IL23 FMT IBD Jakinibs [DOI] 10.1007/s00535-018-1449-z PMC 바로가기 [Article Type] Review
Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent혈통에 의한 신원을 사용하여 지역 Plasmodium falciparum 말라리아 기생충 개체군 간의 연결성 정량화Research Article Published on 2017-10-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] Accessibility Analysis approach assessment association Author best biological processe biological processes can not chance classic classical clinics collected data set descent detect disease dispersal Divergence drug resistance Ecology effort eliminating endangered species Epidemiology Evolution Genetic genomic data Genomics genotyped human pathogen IBD identity identity by descent increasingly inheritance knowledge Local malaria malaria parasite malaria parasites measure Molecular epidemiology nucleotide organism Organisms parasite Plasmodium falciparum Population power provide proximal Recombination required robust sampling sequenced significant decrease Single nucleotide polymorphism single nucleotide polymorphisms SNPs spatiotemporal Spread Surveillance Transmission transmission patterns whole genome [DOI] 10.1371/journal.pgen.1007065 PMC 바로가기 [Article Type] Research Article
Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease인간 단핵구 유래 대식세포 전사체 및 지질다당류에 대한 반응 분석은 염증성 장 질환의 유전적 병인에 대한 새로운 통찰력을 제공합니다Research Article Published on 2017-03-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 48 hours Activation adaptation aetiology Analysis appearance arise Arthritis Bacteria Bacterial bacterial cells bacterial lipopolysaccharide bacterial stimuli Blood CAGE CAGE-based transcriptional profiling candidate candidate gene Candidates cascade Cell cells chronic inflammatory bowel diseases Cluster colony-stimulating factor complex component components Course Crohn’s disease CSF1 CSF1-dependent monocyte-macrophage transition CSF1-dependent monocyte-macrophage transitions Defense differentiation dysregulation enhancer enhancers eRNA transcription Families form function gastrointestinal mucosa Gene Expression Genetic genetic risk Genome genome-wide association Genome-wide association studies Gut gut wall GWA human cell human cells human monocyte human monocyte-derived macrophage human monocyte-derived macrophages hypothesised IBD IBD loci identify Immune cell immune cells Inflammatory bowel disease inflammatory bowel diseases inflammatory disease inheritance initiate inflammation intestinal lamina propria intestine involved lipopolysaccharide loci locus long non-coding RNA LPS Macrophage macrophage colony-stimulating factor macrophage differentiation macrophages majority MARA modulate monocyte monocyte differentiation monocyte-derived macrophage monocyte-specific genes Monocytes motif motif activity response analysis Pathogens positive produced promoter promoters provide Region regulated Regulation Regulatory responsible rheumatoid arthritis shown successive wave successive waves Support susceptibility susceptibility loci These data this system tissue damage tissues traits transcription factor transcription factors transcriptional activation transcriptional regulation Transcriptome transcriptome dataset transcripts transient gene expression ulcerative colitis utilised wall [DOI] 10.1371/journal.pgen.1006641 PMC 바로가기 [Article Type] Research Article
A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy게놈 전체 관련 연구에서 lncRna가 나병의 병리학적 염증 반응에 대한 위험 인자로 확인됨Research Article Published on 2017-02-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 한센병, [키워드] 95% CI Affect Analysis association Brazil chromosome clinically Combined dataset disease eQTL etiologies evaluated Evidence evidence of example excessive inflammatory response experimental evidence Factor Genetic genetic control genetic factors Genetic variant Genome Genome-wide association study genomic GWAS GWAS meta-analysis Host IBD identify independent Inflammatory bowel disease inflammatory disorders Inflammatory response initial leprosy lncRNA loci locus mechanism nerve nerve damage occur offspring overlap Patient peripheral nerve reaction Reactions replicated Replication responses risk risk factor Risk factors separated SNP SNPs Support susceptibility undergo [DOI] 10.1371/journal.pgen.1006637 PMC 바로가기 [Article Type] Research Article