The GATA Transcription Factor egl-27 Delays Aging by Promoting Stress Resistance in Caenorhabditis elegansGATA 전사 인자 egl-27은 꼬마선충의 스트레스 저항성을 촉진하여 노화를 지연시킵니다Research Article Published on 2012-12-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulated activated Affect age aging aging process alteration animals Author Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans conserved daf-16 Delay Effect elegan expression Factor Factors found FoxO GATA GATA transcription factor Gene Genes heat stress identify IGF-1 impair IMPROVE increase inhibited insulin Intersection involved limit Longevity molecular mechanism molecular mechanisms mutant overexpression oxidative stress pathway Pathways promote Promoting PROTECT protective response protective responses receptor reduced required resistance response Signaling significantly Stress stress response stress responses suppresse survival target transcription factor wild-type worm worms [DOI] 10.1371/journal.pgen.1003108 PMC 바로가기 [Article Type] Research Article
Patterns of Ancestry, Signatures of Natural Selection, and Genetic Association with Stature in Western African Pygmies서아프리카 피그미족의 조상 패턴, 자연 선택의 서명 및 키와의 유전적 연관성Research Article Published on 2012-04-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive African Anatomy ancestry approach association Author average candidate gene chromosome chromosome 3 CISH Cluster cytokine cytokine signaling demography DOCK3 enrichment European Europeans Evolution extreme found Gene Genetic genetic association genetic diversity Genome genomic region globe group growth growth factor growth hormone Height highest Human human population human populations identify Illumina Immunity include indicate inhibit insulin insulin-like growth factor involved Local location loci metabolism natural natural selection neuroendocrine Pathway analysis Pathways pattern phenotypic phenotypic diversity phenotypic variation Physiology Population Positive selection Region regulate reproduction Selection short stature Signaling signaling pathways signature SNP stature target targets the strongest thought tropical unique variant variants Variation [DOI] 10.1371/journal.pgen.1002641 PMC 바로가기 [Article Type] Research Article