Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication
코로나바이러스 엔도리보뉴클레아제 nsp15에 의한 항바이러스 스트레스 과립 형성 억제로 효율적인 바이러스 복제 보장
Research Article
[키워드] accumulation
Activation
affected
aggregation
Analysis
antagonist
antagonists
Anti-viral
Antiviral
array
cells
conserved
coronavirus
Coronavirus infection
Coronaviruses
Critical
Crosstalk
decrease
demonstrated
Depletion
dsRNA
eIF2α
ENCODE
endoribonuclease
Evidence
Factors
function
Heat shock
Host
host antiviral response
host cell
host response
IBV
IBV infection
IFN response
IFN-β
immune response
immunofluorescence analysis
include
increase
infected cells
Infection
Infectious Bronchitis Virus
inhibiting
inhibition
innate immune
interfere
Interference
intrinsic
IRF3
knowledge
mechanism
mRNAs
NaCl
Nsp15
overcome
overexpressed
Pattern recognition
pattern recognition receptor
Pattern recognition receptors
PEDV
Phosphorylation
PKR
prevalent
Prevent
Protein
protein synthesis
provided
PRRs
Recognition
recruitment
reducing
Replication
reported
responsible
RNA viruses
SARS-CoV
SARS-CoV-2
scaffold proteins
shown
Signaling
sodium
sodium arsenite
Stress
stress granule
stress response
suppression
TGEV
Transcription
translation
Trigger
triggered
turn
Viral
viral dsRNA
virus
virus replication
viruses
wild type
[DOI] 10.1371/journal.ppat.1008690 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1008690 PMC 바로가기 [Article Type] Research Article