The Altered Anatomical Distribution of ACE2 in the Brain With Alzheimer’s Disease PathologyCell and Developmental Biology Published on 2021-06-252022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome addition Altered Alzheimer’s disease Alzheimer’s disease anatomical distribution angiotensin-converting enzyme 2 Brain brain region brain regions caused cells Central nervous system contribute coronavirus coronavirus disease COVID-19 COVID-19 patient downregulated Endothelial cell expressed expression level immunohistochemistry Invasion manifestation mapped Neurological symptom nucleus pandemic pathology protein level Research SARS-CoV-2 suggested [DOI] 10.3389/fcell.2021.684874 PMC 바로가기 [Article Type] Cell and Developmental Biology
Replication Kinetics, Cell Tropism, and Associated Immune Responses in SARS-CoV-2- and H5N1 Virus-Infected Human Induced Pluripotent Stem Cell-Derived Neural ModelsResearch Article Published on 2021-06-232022-10-30 Journal: mSphere [Category] COVID-19, MERS, SARS, [키워드] accumulating ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 associated immune response Brain cell tropism cell type cells Central nervous system cerebrospinal fluid CNS contribute coronavirus COVID-19 COVID-19 patients Culture cultures disease Evidence expression H5N1 H5N1 influenza A H5N1 virus highly pathogenic hiPSC neurons Human Hypothesis IL-8 induced infect Infection influenza A virus Influenza virus interferon Invasion investigated Kinetics local immune response Model Neural Neurological complication Neurological complications Neuron neurons neurotropic neurotropism NPR1 olfactory Pathogenesis pluripotent stem cell protease replicated replication kinetics response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication serine 2 Spread STEM subsequent Support TMPRSS2 transmembrane triggered triggering tropism type III interferon variety virus virus replication virus spread [DOI] 10.1128/mSphere.00270-21 PMC 바로가기 [Article Type] Research Article
Persistent cognitive impairment associated with cerebrospinal fluid anti-SARS-CoV-2 antibodies six months after mild COVID-19Letter to the Editor Published on 2021-06-212022-10-30 Journal: Neurological Research and Practice [Category] COVID-19, [키워드] acute phase affected anti-SARS-CoV-2 antibody Central nervous system cerebrospinal fluid Cognitive impairment COVID-19 COVID-19 pandemic CSF antibodies disease Evidence female implementation increasingly individual Invasion long-lasting Mild Neurologic sequelae Neurological symptom Patient persistent SARS-CoV-2 SARS-COV-2 infection supplementary material the disease virus [DOI] 10.1186/s42466-021-00135-y PMC 바로가기 [Article Type] Letter to the Editor
microRNA Heterogeneity, Innate-Immune Defense and the Efficacy of SARS-CoV-2 Infection—A CommentaryCommentary Published on 2021-06-182022-10-30 Journal: Non-Coding RNA [Category] COVID-19, [키워드] Homo sapien (hsa) activity acute respiratory distress acute respiratory syndrome biochemical cause cellular Coronavirus-2 COVID-19 COVID-19 pandemic disease Efficiency explain family Coronaviridae Genetic Genome genus Betacoronavirus host cell host miRNAs human miRNA immunological implication indicate individual individuals Infection Inflammatory Invasion Messenger RNA messenger RNA (mRNA) microRNA microRNA (miRNA) miRNA miRNAs modulation mRNA mRNA abundance Neurological complications neutralization non-coding RNA nucleotide pathological pathophysiological progression recent Replication Research SARS-CoV-2 SARS-COV-2 infection Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) single-stranded Support susceptible systemic disease tissue Variability viral genome viral infection Viral pneumonia Viral RNA [DOI] 10.3390/ncrna7020037 PMC 바로가기 [Article Type] Commentary
SARS-CoV-2: Origin, Evolution, and Targeting InhibitionSARS-CoV-2: 기원, 진화 및 표적 억제Review Published on 2021-06-172022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 진단, [키워드] (RdRp ACE2 acute respiratory diseases acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed angiotensin angiotensin converting enzyme antibodies antibody bind carried caused China comparison complex structure coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D614G described drug effective enzyme Evolution help host cell in viral Infection inhibit inhibition inhibitor Invasion involved mechanism MPro mutant Neutralizing antibodies neutralizing antibody non-structural proteins origin outbreak pandemic pathogenic pathogenic mechanism physiological protease Protein proteolytic RdRP receptor recognize Replication respiratory respiratory diseases responsible RNA-dependent RNA polymerase S protein SARS-CoV-2 second wave severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 small molecule small molecule inhibitor Small molecule inhibitors Spread Structure targeting targeting inhibition therapeutic target transcription processes Viral viral genome replication viral invasion Viral RNA Wuhan [DOI] 10.3389/fcimb.2021.676451 PMC 바로가기 [Article Type] Review
Microglial Implications in SARS-CoV-2 Infection and COVID-19: Lessons From Viral RNA Neurotropism and Possible Relevance to Parkinson’s DiseaseNeuroscience Published on 2021-06-152022-10-31 Journal: Frontiers in Cellular Neuroscience [Category] COVID-19, [키워드] acute respiratory syndrome addition Brain cells Central nervous system change clearance CNS contribute coronavirus Coronavirus disease 2019 COVID-19 death delirium disease disorders Genetic globe highlight homeostatic Hyposmia immunopathology in viral include individual Infection infections Invasion lesson mechanism Meningitis MERS-CoV microglia microglial Middle East neurodegeneration Neurodegenerative diseases Neuroinvasive neurological Neurological symptom neurons neuropsychiatric disorders neurotropic outbreak pandemic Parkinson’s disease Parkinson’s disease pathogenic pathophysiology plasticity provide re-infected Reinfection Relevance respiratory syndrome coronavirus response responsible rising RNA RNA virus SARS-CoV-2 SARS-COV-2 infection stroke vasculature viral clearance viral infection viral RNA neurotropism [DOI] 10.3389/fncel.2021.670298 PMC 바로가기 [Article Type] Neuroscience
Modeling within-Host SARS-CoV-2 Infection Dynamics and Potential Treatments호스트 내 SARS-COV-2 감염 역학 및 잠재적 치료 모델링Article Published on 2021-06-142022-09-01 Journal: Viruses [Category] MERS, 진단, 치료제, [키워드] adaptive Adaptive immune response Administered anti-SARS-CoV-2 antibodies collected convalescent plasma convalescent plasma transfusion COVID-19 COVID-19 patients develop drug Dynamics effective effector cells host cells hypothetical Immune components immune response in silico infected cell infected cells Infection inhibit Innate immunity interferon Intervention Invasion mathematical mathematical model mathematical modeling modeling onset of symptoms Plasma cell Plasma cells platform Potential Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 virus infection shown Simulation target cell target cells therapy Transcription Transfusion therapy Trigger triggers Vaccines Viral Viral load virus virus infection virus-specific antibodies [DOI] 10.3390/v13061141 PMC 바로가기 [Article Type] Article
Human Cathelicidin Inhibits SARS-CoV-2 Infection: Killing Two Birds with One Stone인간 카텔리시딘은 SARS-CoV-2 감염을 억제합니다: 하나의 돌로 두 마리의 새 죽이기Article Published on 2021-06-112022-09-11 Journal: ACS Infectious Diseases [Category] SARS, 유전자 메커니즘, [키워드] ACE2 Adenovirus administration affinity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 antimicrobial peptide association bind Bird blockade Cathelicidin Cell coronavirus disease Coronavirus disease 2019 COVID-19 decrease domain enzyme expressing half-maximal inhibitory concentration high affinity Host Human human ACE2 in vitro Infection inhibit inhibitor Interaction Invasion Lung infection mechanisms mice peptide Protein RBD Receptor binding Receptor binding domain Receptor-binding domain recruitment SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S spike Stone subsequent targeting the RBD the receptor-binding domain Treatment [DOI] 10.1021/acsinfecdis.1c00096 PMC 바로가기 [Article Type] Article
Antiviral, Antibacterial, Antifungal, and Antiparasitic Properties of Propolis: A ReviewReview Published on 2021-06-112022-11-01 Journal: Foods [Category] COVID-19, [키워드] Anti-inflammatory anti-parasitic Antibacterial Antifungal antioxidant antiparasitic Antiviral apiculture cellular cellular organelle complex component demonstrated disrupting Efficacy enzyme function help Host host cell host cells Human human clinical trial immunomodulator Impact infections inflammatory signaling inhibit inhibiting Innate immunity Invasion maintain mechanism metabolic processe modulate pathogen pathogenic Pathogens Pathways physical barrier phytochemical property Propolis Protein Replication responsible review therapy upregulate [DOI] 10.3390/foods10061360 PMC 바로가기 [Article Type] Review
Podocalyxin in Normal Tissue and Epithelial CancerReview Published on 2021-06-082023-08-30 Journal: Cancers [Category] E형 간염, [키워드] chemoresistance EMT epithelial cancer extravasation immune evasion Invasion Metastasis Migration podocalyxin PODXL tumour budding [DOI] 10.3390/cancers13122863 PMC 바로가기 [Article Type] Review