lung damage – Page 18 – Communicable Diseases Research

Hypothesis: Pentoxifylline is a potential cytokine modulator therapeutic in COVID‐19 patients

Review

Published on 2020-07-262022-10-29
Journal: Pharmacology Research & Perspectives
[Category] COVID-19, MERS,

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

Randomized Controlled Trial

Published on 2020-07-172022-10-04
Journal: The New England Journal of Medicine
[Category] Fulltext, MERS, 임상,

Recovery of COVID-19 acute respiratory distress syndrome with tocilizumab: successful outcome in two critically ill patients

Case Report

Published on 2020-07-152022-10-31
Journal: Immunotherapy
[Category] COVID-19, MERS, SARS,

Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies

Immunology

Published on 2020-07-032022-11-01
Journal: Frontiers in Immunology
[Category] COVID-19, MERS, SARS,

[키워드] administration alveolar macrophage animal model binding blockade blunting cells circulating Clinical improvement clinical trial compassionate use COVID-19 Cytokine release syndrome death described driven by FDA approval GM-CSF healthy controls help Hospitalization hyperinflammation IL-6 Increased Inflammatory cytokine Inflammatory response inflammatory signaling interferon-γ intranasal intravenous dose involved lung damage Macrophage macrophages mavrilimumab mechanical ventilation Mild symptom monoclonal antibodies monoclonal antibody MOST outcomes Oxygenation patients with COVID-19 placebo-controlled trial produced proliferation Prospective provided Randomized rationale receptor Respiratory failure respiratory infections SARS-CoV-2 Severe case severe pneumonia Signaling Strategy syndrome T-cells targeting tested treated Trial while
[DOI] 10.3389/fimmu.2020.01625 PMC 바로가기 [Article Type] Immunology

ADL-dependency, D-Dimers, LDH and absence of anticoagulation are independently associated with one-month mortality in older inpatients with Covid-19

Research Paper

Published on 2020-06-302022-10-28
Journal: Aging (Albany NY)
[Category] COVID-19, SARS,

Immune Parameters and COVID-19 Infection – Associations With Clinical Severity and Disease Prognosis

Cellular and Infection Microbiology

Published on 2020-06-302022-10-31
Journal: Frontiers in Cellular and Infection Microbiology
[Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome adaptive Analysis Asymptomatic authors caused CD3 CD4 CD8 cellular immunity change clinical clinical status clinical trial complex coronavirus Coronavirus 2019 Course COVID-19 Cytokine storm diagnostic Eosinopenia examination help Hospitalization identify immune change immune parameter Immunity immunoparalysis increase Infectious disease intensive care lung damage lymphopenia majority mild symptoms non-severe patients Novel coronavirus Patient predict Prognosis Prognostic value proportion recognize reported risk SARS-CoV2 selected Severe patient Significant subject Symptom T cell T lymphocytes the disease Therapeutic strategies while worsening
[DOI] 10.3389/fcimb.2020.00364 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

Letter to the editor: efficacy of different methods of combination regimen administrations including dexamethasone, intravenous immunoglobulin, and interferon-beta to treat critically ill COVID-19 patients: a structured summary of a study protocol for a randomized controlled trial

Letter

Published on 2020-06-192022-10-29
Journal: Trials
[Category] Coronavirus, SARS,

[키워드] 24 hours acute respiratory distress administration Admission age age and sex allergy ARDS Arm blinded Blood oxygen saturation can be used checked clinical coded Combination combination regimen Computed tomography conducted Contact Control control arm Corticosteroid Corticosteroids COVID-19 COVID-19 patients Critically ill Critically ill patient critically ill patients Cytokine storm develop Dexamethasone dissemination dosage dose drug early administration education Efficacy element eligible excessive inflammatory response experimental group Frequency generate group help hepatitis B HIV positive hospital Hospitalization hospitalized patient Hypothesis Immunoglobulin IMPROVE increase in Inflammation information Interferon-beta Intervention intervention group Intravenous immunoglobulin intubation investigator Iran laboratory technician less lung lung damage management mortality rate MOST number Nurses objective outcome Parallel Arm participant Patient patients Patients management percentage positive RT-PCR Pregnancy protocol random random number generator randomised randomised controlled trial randomization Randomized controlled trial Randomly RCT receive reduce Registration reported researcher respiratory rate Sample size severe COVID-19 Side effects Standard standard treatment statistical statistician study drug study group Study protocol subject supportive care syndrome the cytokine storm the WHO treat Treatment Trial website WHO guideline
[DOI] 10.1186/s13063-020-04499-5 PMC 바로가기 [Article Type] Letter

Efficacy and safety of aerosolized intra-tracheal dornase alfa administration in patients with SARS-CoV-2-induced acute respiratory distress syndrome (ARDS): a structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-06-192022-10-29
Journal: Trials
[Category] COVID-19, SARS,

[키워드] 1:1 24 hour acute respiratory distress Administered administration Aerogen Aerogen Solo® Aerosols age airway alveolar alveolar injury anticipated ARDS backbone Berlin criteria blinded blocker Breastfeeding carrier cell-free DNA citrullinated histones clearance cleave Clinical practice clinical trial comparator Compound computer-generated consecutive patient control arm coronavirus 2 coronavirus disease COVID-19 COVID-19 patients criteria damage-associated molecular pattern DAMP DAMPs diagnosed with COVID-19 dissemination distal Dornase alfa dose double-stranded DSMB Efficacy element eliminated enteral nutrition Extracellular extracellular DNA fibrosis glycemic control hospital Hospitalized hospitals hyperinflammation hypersensitivity ICU Inclusion inclusion criteria induce Inflammation intensive care interim analysis Intervention Ireland less looser lung lung damage Lungs management mechanical ventilation mechanically ventilated patient monitoring board myeloperoxidase NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps number objective Occurrence Open-label outcome PaO Paris participant Patient patients PEEP performed Pneumocytes Primary outcome progression Prone position Protective protocol randomisation randomised randomised controlled trial Randomized receive recruit recruitment reduce reducing Registered respiratory Roche Rothschild Sample size SARS-CoV-2 secretion Sedation Severe COVID-19 pneumonia severe pneumonia severity statistical analysis status study group Study protocol Switzerland syndrome to define Toxicity tracheal Treatment Trial usual care Ventilation vibrating mesh nebulizer Volume website
[DOI] 10.1186/s13063-020-04488-8 PMC 바로가기 [Article Type] Letter

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

Research

Published on 2020-06-092022-10-05
Journal: Nature
[Category] SARS, 비임상, 임상, 진단, 치료제,

[키워드] acute respiratory syndrome animal model animal models Antiviral approved authorization benefit Bronchoalveolar lavage clinical clinical benefit clinical trial coronavirus coronavirus disease COVID-19 drug effective Efficacy Emergency first dose food GS-5734 in vivo infected with SARS-CoV-2 Infection inhibited initiated investigated lack lung damage lung viral load macaque MERS-CoV Middle East nucleotide patients with COVID-19 Pneumonia potential treatments preclinical data Prevent progression pulmonary infiltrate reduced Remdesivir Replication Repurposed drug respiratory syndrome coronavirus rhesus rhesus macaque SARS-CoV-2 severe disease suggested Support therapy treat treated Treatment upper respiratory tract Virus shedding virus titre while
[DOI] 10.1038/s41586-020-2423-5 [Article Type] Research

Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors

Research Article

Published on 2020-05-312022-10-06
Journal: Emerging Microbes & Infections
[Category] MERS, SARS, 진단,

[키워드] Analysis analyzed can be used control sample coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill patient CRP cytokine Cytokine storm death Diagnosis disease deterioration disease severity enrolled group healthy volunteer higher risk IFN-γ IL-10 IL-2 IL-4 IL-6 immunoassays indicated individuals Inflammatory cytokines Interleukin 10 interleukin 6 Logistic regression analysis lung damage majority Mild moderate multiple organ dysfunction outbreak outcome Patient positively correlated Predictive predictor profile Profiling reduce Renmin Hospital Respiratory failure Result reveal SARS-CoV-2 serum serum cytokine Serum level serum sample severe disease significantly higher Spread Symptoms syndrome TNF-α Treatment while Wuhan, China
[DOI] 10.1080/22221751.2020.1770129 PMC 바로가기 [Article Type] Research Article