The Adjuvanticity of an O. volvulus -Derived r Ov -ASP-1 Protein in Mice Using Sequential Vaccinations and in Non-Human PrimatesResearch Article Published on 2012-05-172022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Activation adjuvant adjuvanticity administration anti-RBD antibody Antibody Response antigens bystander Course DC different Effectiveness Efficacy element first vaccination functional host response IFN-γ IgG2a IL-2 IL-6 immunized induce Influenza virus maturation mice naïve NHPs non-human primate not affect Onchocerca volvulus primate promote promoted Protective protective immune response Protein provided RBD reported retained SARS-CoV spike protein sera subsequent Th1 Th1 cytokines Th2 response the receptor-binding domain titre TNF-α upregulated utility vaccination Vaccine vaccine antigen virus strains was used [DOI] 10.1371/journal.pone.0037019 PMC 바로가기 [Article Type] Research Article
Interferon Regulatory Factor 8 Regulates Pathways for Antigen Presentation in Myeloid Cells and during Tuberculosis인터페론 조절 인자 8은 골수 세포 및 결핵 기간 동안 항원 제시 경로를 조절합니다Research Article Published on 2011-06-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (major histocompatibility complex activate Activation allele Analysis Antigen presentation antigen processing Author binding binding site cellular pathway cellular pathways chromatin chromatin immunoprecipitation class Combination component Critical cytokine Defense dendritic cell dendritic cells differentiation early response endomembrane eQTLs expressed expression F2 Factor fixed functional Gene gene transcription GTPase GTPases histocompatibility complex Host–pathogen interaction identify IFNγ IL-12 IL12 immune response Infected Infection interferon gamma interferon regulatory factor interleukin intracellular pathogens intrinsic investigated IRF8 lipopolysaccharide LPS lung tissue lung tissues Lungs Macrophage macrophages major histocompatibility complex maturation member MHC mice Microarray Microarrays microbial motif mutant Mycobacterium tuberculosis myeloid myeloid cell myeloid cells ontogeny Pathogens pathway Pathways presentation priming progenitor cells promoter promoters Proteins pulmonary tuberculosis regulated Regulation represse required resistance to infection resistance to infections significantly Stimulation susceptible target transcript Transcription transcriptional treated Tuberculosis wild-type [DOI] 10.1371/journal.pgen.1002097 PMC 바로가기 [Article Type] Research Article
Topographic Changes in SARS Coronavirus–infected Cells at Late Stages of InfectionResearch Published on 2004-11-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] Actin active site addition atomic Atomic force microscopy Cell change coronavirus cytoskeletal filament Final infected cell Infection involved maturation Microscopy plasma membrane progeny provided Research SARS coronavirus replication SARS-CoV scanning scanning electron microscopy spike Stage virus virus particle virus particles was used [DOI] 10.3201/eid1011.040195 PMC 바로가기 [Article Type] Research