Seaweeds and Their Natural Products for Preventing Cardiovascular Associated DysfunctionReview Published on 2021-09-072022-10-30 Journal: Marine Drugs [Category] COVID-19, [키워드] Activation cardiovascular cardiovascular disease cascade component condition conducted CVD death dietary change disease drugs dyslipidemia Effect endothelial cell damage greatly reduce high mortality rate hypertension in vitro In vitro studies in vivo involved marker mechanism metabolite natural natural product oxidative stress Pathogenesis plant Prevalence Preventing product provide Research seaweed terrestrial thought treatment effects unique Vascular vascular endothelial cell [DOI] 10.3390/md19090507 PMC 바로가기 [Article Type] Review
Microbial Metabolites: The Emerging Hotspot of Antiviral Compounds as Potential Candidates to Avert Viral Pandemic Alike COVID-19Molecular Biosciences Published on 2021-09-072022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] accumulated acute respiratory syndrome Anti-SARS-CoV-2 Activity Antiviral antiviral agent antiviral drugs Bacteria Bacterial base can be used candidate caused Compound coronavirus Coronaviruses COVID-19 COVID-19 pandemic effective English fungal fungi global healthcare Google mechanism mechanism of action metabolite metabolites microbial microbial metabolites novel antiviral drug pandemic Pandemics Potential Research researcher retrieved SARS-CoV-2 Scientific community tested the SARS-CoV-2 Topic Viral diseases virus viruses were excluded were used [DOI] 10.3389/fmolb.2021.732256 PMC 바로가기 [Article Type] Molecular Biosciences
Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19 Research Published on 2021-09-062022-10-05 Journal: Nature biotechnology [Category] 바이오마커, 치료기술, [키워드] acute respiratory syndrome alteration Analysis blood draw change changes in Clinical diagnosis clinical symptom collected coronavirus coronavirus disease COVID-19 disease severity dominant Immune cell individual individuals with COVID-19 Infection metabolite monocyte peripheral immune response plasma predict protein level reveal robust SARS-CoV-2 single-cell subpopulation survival T cell [DOI] 10.1038/s41587-021-01020-4 [Article Type] Research
Combination Therapy with Fluoxetine and the Nucleoside Analog GS-441524 Exerts Synergistic Antiviral Effects against Different SARS-CoV-2 Variants In VitroArticle Published on 2021-09-032022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] activated activating ADK analyzed Antiviral antiviral activity antiviral drug Antiviral effect Antiviral treatment approach Calu-3 cell circulating SARS-CoV-2 variant combination therapy combined treatment Culture drug interaction Drug repurposing Effect Enzymes expressed Fluoxetine GS-441524 in vitro kinase metabolite nucleoside nucleoside GS-441524 offer patients with COVID-19 plasma Remdesivir reported Safe SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 pandemic synergistic synergy Therapeutic treatment tissues Treatment [DOI] 10.3390/pharmaceutics13091400 PMC 바로가기 [Article Type] Article
Host metabolic reprogramming in response to SARS-CoV-2 infection: A systems biology approachSARS-CoV-2 감염에 대한 숙주 대사 재프로그래밍: 시스템 생물학 접근법Article Published on 2021-09-012022-09-11 Journal: Microbial pathogenesis [Category] SARS, 신약개발, 유전자 메커니즘, [키워드] alteration Amino acid amino acid metabolism Analysis analyzed Antiviral approach Bronchoalveolar lavage fluid cell line change COVID-19 dysregulation effective expression pattern glutathione glutathione metabolism Glycolysis Host host-pathogen interaction hypothese hypotheses immunomodulation in vitro study lipid metabolism lung lung biopsy metabolic gene metabolic genes metabolism metabolite mitochondrial mitochondrial metabolism mononuclear cells Nasopharyngeal swab network model nucleotide Pathogenesis pathogenesis of SARS-CoV-2 Pathways Patient Peripheral blood Peripheral blood mononuclear cells polyamine Polyamine metabolism polyamine synthesis redox Redox homeostasis reducing Replication reporter resource SARS-CoV-2 SARS-COV-2 infection survival Systems biology transcriptomic data transcriptomics Treatment strategies understanding viral titer viral titers Warburg effect [DOI] 10.1016/j.micpath.2021.105114 PMC 바로가기 [Article Type] Article
A phase I study of high dose camostat mesylate in healthy adults provides a rationale to repurpose the TMPRSS2 inhibitor for the treatment of COVID-19건강한 성인을 대상으로 한 고용량 카모스타트 메실레이트에 대한 1상 연구는 COVID-19 치료를 위해 TMPRSS2 억제제를 용도 변경하는 근거를 제공합니다Clinical Trial Published on 2021-09-012022-09-11 Journal: Clinical and translational science [Category] 신약개발, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Administered camostat Camostat mesylate Cell chronic pancreatitis Concentration conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dosages effective evaluated half-maximal effective concentration healthy High dose High-dose Infection inhibit inhibiting meal metabolite no significant difference Pancreatitis Phase I Phenylacetic acid plasma provide reflux esophagitis reported respiratory Safe safety profile Serine serine protease inhibitor severe acute respiratory syndrome Coronavirus significantly Simulation TMPRSS2 inhibitor transmembrane serine protease treat Treatment type II transmembrane serine protease [DOI] 10.1111/cts.13052 PMC 바로가기 [Article Type] Clinical Trial
Immunometabolic signatures predict risk of progression to sepsis in COVID-19Research Article Published on 2021-08-302022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 95%CI amino acid metabolism Analysis AUC chemokines Clinical finding correlation COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill patients diabetes Diagnosis disease dysregulation early diagnosis Glycolysis help hyperinflammation IL-6 implementation In-hospital individuals Inflammatory cytokines lipid metabolism metabolism metabolite metabolomics Mild mild patient mitochondrial metabolism Mortality multisystemic neutrophil activation NLR Non-COVID-19 patients who survived plasma sample polyamine synthesis predict Prognosis progression quantified risk sensitivity Sepsis sepsis patient septic septic patients Severe patient severity specificity Treatment Type [DOI] 10.1371/journal.pone.0256784 PMC 바로가기 [Article Type] Research Article
β-Carboline alkaloids induce structural plasticity and inhibition of SARS-CoV-2 nsp3 macrodomain more potently than remdesivir metabolite GS-441524: computational approachArticle Published on 2021-08-302022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] β-carboline ADP-ribose ADP-ribosylation analogue anti-SARS-CoV-2 approach binding affinity binding free energy bioinformatics candidate computational approach coronavirus creating database demonstrated docking docking score drug design Glide GS-441524 Host immune response implicated indicated induce Infection Ligand ligands low expression macrodomain macromolecule metabolite modulated Molecular dynamics simulation Nsp3 nsp3 macrodomain parameter Pathogenesis plasticity predicted receptor Remdesivir reported SARS-CoV-2 screened selected small molecule stability the SARS-CoV-2 Toxicity viral replication [DOI] 10.3906/biy-2106-64 PMC 바로가기 [Article Type] Article
Neuropathy in COVID-19 associated with dysbiosis-related inflammationArticle Published on 2021-08-302022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] Affect association Brain circulatory system Complication complications conditions contribute COVID-19 COVID-19 patient COVID-19 severity cytokine described diarrhea disease distal gastrointestinal system Gut gut microbiota gut microbiota dysbiosis gut–brain axis gut–lung axis homeostasis Host immune dysfunction immune response immune system impair induce Inflammation involved Kynurenine pathway lung maintain metabolite microbe microbial microbial product microbiota neurodegenerative Neuroinflammation neurologic Neurological symptom neuropathic Neuropathy organ Pain pathophysiology Patient patients with COVID-19 resulting SARS-COV-2 infection severe COVID-19 patient severity systemic inflammation the disease translocation turn [DOI] 10.3906/biy-2105-53 PMC 바로가기 [Article Type] Article
GC-MS, LC-MS/MS, Docking and Molecular Dynamics Approaches to Identify Potential SARS-CoV-2 3-Chymotrypsin-Like Protease Inhibitors from Zingiber officinale RoscoeGC-MS, LC-MS/MS, 도킹 및 분자 역학 접근법은 Zingiber Officinale Roscoe로부터 잠재적 인 SARS-COV-2 3- chymotrypsin- 유사 프로테아제 억제제를 식별하기위한 접근법.Article Published on 2021-08-282022-08-31 Journal: Molecules [Category] SARS, 치료제, [키워드] Zingiber officinale 24-Methylcholesta-7-en-3β-on 3CL 3CL Protease absence Analysis binding energy chymotrypsin complex Compound compounds docking Dynamics enzyme evaluate GC-MS identify inhibitory activity inhibitory potency Isolation LC-MS/MS MD simulation MD simulations metabolite methanol molecular molecular docking molecular dynamics molecular interaction NMR nootkatone positive control Potential Predictive protease SARS-CoV-2 Secondary Metabolite secondary metabolites spinasterol stability steroid Steroids suggested Zingiber [DOI] 10.3390/molecules26175230 PMC 바로가기 [Article Type] Article