A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymeraseSARS-CoV-2 RNA 의존성 RNA 중합효소의 억제제를 발견하기 위한 세포 기반 분석Article Published on 2021-06-012022-09-11 Journal: Antiviral Research [Category] SARS, 치료제, [키워드] addition Antiviral antiviral therapeutics antivirals biochemical assay Cell cells chemical process Compound conversion COVID-19 COVID-19 pandemic COVID-19 patients EC50 effective Efficacy entecavir evaluate evaluated examined Favipiravir forms High-throughput highest in vitro increase inhibitors inhibitors of SARS-CoV-2 molnupiravir nsp14 nucleotide Nucleotide analog inhibitor nucleotide prodrug nucleotide prodrugs occur Penciclovir polymerase provide RdRP Remdesivir ribavirin RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RdRp inhibitor Seven suggested tenofovir threshold Tolerance treat triphosphate utility Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.1016/j.antiviral.2021.105078 PMC 바로가기 [Article Type] Article
Disease-drug and drug-drug interaction in COVID-19: Risk and assessmentReview Published on 2021-04-272023-06-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, [키워드] COVID-19 CYPs Dexamethasone drug transporters molnupiravir Remdesivir [DOI] 10.1016/j.biopha.2021.111642 PMC 바로가기 [Article Type] Review
Overcoming Culture Restriction for SARS-CoV-2 in Human Cells Facilitates the Screening of Compounds Inhibiting Viral ReplicationArticle Published on 2021-04-262023-06-15 Journal: Antimicrobial Agents and Chemotherapy [Category] MERS, SARS, [키워드] A549 cells coronavirus COVID-19 Galidesivir Huh7.5 cells molnupiravir nucleotide analogs Remdesivir sofosbuvir Virus evolution [DOI] 10.1128/AAC.00097-21 PMC 바로가기
Quest for a Cure: Potential Small-Molecule Treatments for COVID‑19, Part 2Review article Published on 2021-04-192022-10-05 Journal: Organic Process Research & Development [Category] 신약개발, 치료법, 치료제, [키워드] antiviral drug approved classical clinical trial clinical trials Covid patients COVID-19 COVID-19 pandemic COVID‐19 described Dexamethasone drug drug candidate drugs effective Europe evaluated molnupiravir Mortality occurred outbreak Part Potential quest reduction in Remdesivir repurpose Seven shown the disease Treatment [DOI] 10.1021/acs.oprd.1c00100 [Article Type] Review article
Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity against SARS-CoV-2Antiviral Agents Published on 2021-03-012022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID-19, [키워드] activity acute respiratory syndrome Administered administration adverse event agent Antiviral AUC C max clinically Concentration coronavirus COVID-19 declined decrease dose Dose escalation double-blind EIDD-1931 EIDD-2801 Electrocardiography evaluated exceeded expected first in human geometric healthy volunteers highest dose Human incidence influenza viruses Laboratory median time MERS-CoV Middle East Mild molnupiravir multiple dose multiple doses no decrease novel oral pandemic pharmacokinetics Phase 1 Placebo placebo-controlled study plasma plasma concentration Randomized Rash reached Registered reported respiratory syndrome coronavirus Ribonucleoside analog ribonucleoside analogue RNA viruses Safety SARS-CoV SARS-CoV-2 Serious Adverse Events single dose subject tested Tolerability vital signs [DOI] 10.1128/AAC.02428-20 PMC 바로가기 [Article Type] Antiviral Agents
Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other CoronavirusesSARS-CoV-2 및 기타 코로나바이러스와의 싸움에서 약물로서의 뉴클레오사이드 유사체 및 뉴클레오사이드 전구체Review Published on 2021-02-132022-08-31 Journal: Molecules [Category] MERS, 신약개발, 치료제, [키워드] active against acute respiratory syndrome approach China colds common colds coronavirus coronavirus disease CoV COVID-19 CoVs derivative drug effective drug effective drugs effective therapy Epidemics family Coronaviridae Favipiravir focus growth HCoV Health Organization human CoV humans Infection infections inhibit lead main mechanism mammal mammals mass vaccination MERS MERS-CoV Middle East Middle East respiratory syndrome Mild molnupiravir nucleoside nucleoside drugs nucleosides Other pandemic positive result positive-sense precursor provide Remdesivir respiratory respiratory diseases respiratory infections responsible ribavirin RNA SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe respiratory disease severe respiratory diseases sofosbuvir Spread the SARS-CoV-2 therapy upper respiratory infection vaccination Viral diseases virus viruses while WHO World Health Organization [DOI] 10.3390/molecules26040986 PMC 바로가기 [Article Type] Review