Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudovirusesSARS-CoV-2 감염 또는 mRNA 백신에 의해 유도된 항체는 베타 및 오미크론 슈도바이러스에 대한 중화 활성을 감소시켰습니다.Article Published on 2022-03-022022-09-11 Journal: Science Translational Medicine [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibody Antibody Response B.1.1.529 Beta breadth conserved coronavirus Course Delta effective elicited evaluated expressing finding healthy heterogeneity increase Increases individual individuals Infection magnitude mRNA mRNA vaccination mRNA vaccine Multiple Mutation neutralization Neutralizing activity Neutralizing antibody response omicron Omicron variant Omicron variants pandemic populations Preexisting immunity pregnant pregnant women pseudoparticle pseudovirus reduced respiratory response responses robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccines SARS-CoV-2 variants Spike protein stomatitis Support the antibody response the spike protein Transmission Vaccine variant variants vesicular stomatitis vesicular stomatitis virus Viral Viral antigen viral antigens VSV wild-type [DOI] 10.1126/scitranslmed.abn7842 PMC 바로가기 [Article Type] Article
Molecular variants of SARS-CoV-2: antigenic properties and current vaccine efficacyReview Published on 2022-03-022023-06-16 Journal: Medical Microbiology and Immunology [Category] COVID19(2023년), MERS, SARS, [키워드] COVID-19 escape mutations Neutralizing activity SARS-CoV-2 Spike protein Vaccines efficacy variants of concern [DOI] 10.1007/s00430-022-00729-6 PMC 바로가기 [Article Type] Review
Vaccination of COVID-19 convalescent plasma donors increases binding and neutralizing antibodies against SARS-CoV-2 variantsCOVID-19 회복기 혈장 기증자의 백신 접종은 SARS-CoV-2 변이체에 대한 결합 및 중화 항체를 증가시킵니다Article Published on 2022-03-012022-09-11 Journal: Transfusion [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 Alpha antibody assays Beta binding binding antibody boost CCP collected concurrence controlled trials convalescent plasma COVID-19 COVID-19 convalescent plasma D614G Donor Effect Epsilon First wave IgG Immunotherapy increase infected individual log mAb monoclonal antibody MSD neutralization neutralization activity Neutralizing activity Neutralizing antibodies neutralizing antibody no difference observational studies observational study Ortho Vitros Particle pre-vaccination Randomized controlled trials SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants significantly spike Spread tested the SARS-CoV-2 Total total Ig vaccination vaccination rate variant variants Viral was tested Wuhan Wuhan-Hu-1 [DOI] 10.1111/trf.16823 PMC 바로가기 [Article Type] Article
An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies감염성 SARS-CoV-2 B.1.1.529 Omicron 바이러스는 치료용 단일 클론 항체에 의한 중화를 피합니다Article Published on 2022-03-012022-09-11 Journal: Nature Medicine [Category] Fulltext, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected anti-receptor-binding domain antibody AstraZeneca B.1.1.529 Biotechnology Celltrion Clinical use Combination concerning coronavirus decrease Efficacy Lilly LY-CoV555 mAb mAbs monoclonal antibody Mutation neutralization neutralize Neutralizing activity omicron parent reduced Regeneron REGN10933 REGN10987 respiratory S309 SARS-CoV-2 severe acute respiratory syndrome Coronavirus Sotrovimab Spike protein tested the antibody the spike protein therapeutic TMPRSS2 TMPRSS2 cells variant Vero Vero-hACE2-TMPRSS2 cells Vir virus [DOI] 10.1038/s41591-021-01678-y PMC 바로가기 [Article Type] Article
Protective and pathogenic role of humoral responses in COVID-19COVID-19에서 체액 반응의 보호 및 병원성 역할Review Published on 2022-03-012022-09-11 Journal: Journal of microbiology (Seoul, Korea) [Category] MERS, SARS, 변종, 진단, [키워드] accumulating addition advent antibody Antibody Response antibody-escaping variants COVID-19 develop driving dysregulated effective help humoral immune response humoral immune responses Humoral immunity Humoral response humoral responses identify immune pressure immune responses individuals Infection knowledge measure mechanism mutations Neutralizing activity pandemic pathogenic progression Protective Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike-specific specific antibodies spike-specific antibodies understanding vaccination Viral viral pathogen [DOI] 10.1007/s12275-022-2037-8 PMC 바로가기 [Article Type] Review
Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseasesClinical Trial Published on 2022-03-012022-10-05 Journal: Brain, behavior, and immunity [Category] SARS, 임상, [키워드] anti-SARS-CoV-2 ARD ARD patient ARD patients Autoimmune benefit cluster analysis coronavirus covariates defined ENhance exercise exhibited Frequency geometric mean titer GMT greater IgG Immunocompromised patients immunogenicity inactivated Inactivated vaccine inactive individual less lifestyle median Neutralizing activity neutralizing antibody Open-label Patient physical physical activity physically prospective cohort study questionnaire rheumatic disease S1/S2 SARS-CoV-2 SARS-CoV-2 vaccine Sedentary behavior seroconversion rate single-arm Trial vaccination Vaccine virus were assessed [DOI] 10.1016/j.bbi.2021.12.016 PMC 바로가기 [Article Type] Clinical Trial
Evaluation of Commercially Available High-Throughput SARS-CoV-2 Serologic Assays for Serosurveillance and Related Applications혈청 감시 및 관련 응용 분야에 대한 상업적으로 이용 가능한 고처리량 SARS-CoV-2 혈청학적 분석 평가Research Published on 2022-03-012022-09-10 Journal: Emerging Infectious Diseases [Category] MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Algorithm Antibody detection Antigen application assays blinded characterized circulation conducted coronavirus coronavirus disease correlation COVID-19 cumulative cumulative incidence demonstrated dependent on Epidemics evaluated IgG Immunoglobulin incidence Interpretation Intraclass correlation coefficient Neutralizing activity Precision reactivity respiratory respiratory infections SARS-CoV-2 SARS-CoV-2 variants sensitivities sensitivity serologic serologic assay serologic assays Serosurvey severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Specificities specificity specimens total Ig vaccination vaccine-preventable diseases viruses widespread zoonoses [DOI] 10.3201/eid2803.211885 PMC 바로가기 [Article Type] Research
Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination동종 및 이종 CoronaVac 또는 BNT162b2 백신 접종 후 SARS-CoV-2 Omicron 변이체 BA.1에 대한 중화 항체Article Published on 2022-03-012022-09-11 Journal: Nature Medicine [Category] SARS, 변종, 진단, [키워드] antibody Antibody titer BNT162b2 booster booster dose circulating convalescent CoronaVac country dominant dose Effectiveness elicited geometric mean geometric mean titer GMT Heterologous homologous individual infected individual Infection Live virus Messenger RNA Neutralizing activity of BNT162b2 omicron Omicron variant plaque plaque reduction neutralization PRNT reduced reductions reductions in SARS-CoV-2 SARS-CoV-2 virus serum serum antibody Spread the SARS-CoV-2 threshold to define vaccinated individual vaccinated individuals vaccination Vaccine variant virus wild-type WT virus [DOI] 10.1038/s41591-022-01704-7 PMC 바로가기 [Article Type] Article
An engineered bispecific human monoclonal antibody against SARS-CoV-2 Research Published on 2022-02-282022-10-05 Journal: Nature Immunology [Category] COVID19(2023년), SARS, 변종, 비임상, 치료제, [키워드] ACE2 acute respiratory syndrome antibodies binding coronavirus coronavirus disease COVID-19 delta variant described develop effective effective therapy Efficiency escape mutant escape mutants feasible greater human ACE2 Human monoclonal antibody less mAb mAbs monoclonal antibody neutralize Neutralizing Neutralizing activity neutralizing antibody pandemic parental Prevent Prophylactic receptor reduced SARS-CoV-2 SARS-CoV-2 variant selected selective severe COVID-19 therapeutic therapy transgenic mice treat viral titer [DOI] 10.1038/s41590-022-01138-w [Article Type] Research
Generation of neutralizing antibodies against Omicron, Gamma and Delta SARS-CoV-2 variants following CoronaVac vaccinationCoronaVac 백신 접종 후 Omicron, Gamma 및 Delta SARS-CoV-2 변이체에 대한 중화 항체 생성Article Published on 2022-02-252022-09-11 Journal: Revista do Instituto de Medicina Tropical de São [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody Antibody titers booster booster dose Brazil CoronaVac COVID-19 pandemic Cytopathic effect Delta dose elicited evaluated Gamma Generation Health care Health care worker immunization immunized individual Infection limit median Most patients multiple mutation multiple mutations Neutralization antibody neutralization test Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses Neutralizing antibody titer neutralizing capacity omicron Omicron variants Patient Pfizer Prevent raised SARS- CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants second vaccination sera serum samples short duration subject subsequent tested undetectable vaccination Vaccine variant variants was performed were measured [DOI] 10.1590/S1678-9946202264019 PMC 바로가기 [Article Type] Article