Multi-centre, three arm, randomized controlled trial on the use of methylprednisolone and unfractionated heparin in critically ill ventilated patients with pneumonia from SARS-CoV-2 infection: A structured summary of a study protocol for a randomised controlled trial
Letter
[키워드] 24 hour
absolute reduction
Administered
administration
AIFA
airway
allocation sequence
Alpha
Anticoagulant
anticoagulant therapy
Anticoagulant treatment
approval
Arm
Aspergillus
assigned
assumption
average
bleeding
bleeding event
blinded
Block randomisation
block size
BMI
Brain
Breastfeeding
Candida
checked
childbearing age
chronic
clinical
clinical condition
clinically
combined use
conjunctival
contributed
corpus
Corticosteroid
COVID-19
criteria
Critical
Critically ill
cytomegalovirus
D-dimer level
death
defined
Delay
detect
diagnostic
discharge
dissemination
dosage
drug
dysfunction
effective
element
eligible patient
enoxaparin
enrolled
EudraCT
exclusion criteria
expected
hematemesis
hematoma
heparin-induced thrombocytopenia
Herpe
high risk
High-dose
history
hospital
hospital discharge
Hypothesis
ICU
ICU free day
ICU Patients
impairing
Inclusion
inclusion criteria
indicated
Infection
initial
Inpatient
intensive care unit
interval
Intervention
Intra-articular
intramuscular
intravenously
invasive
Invasive mechanical ventilation
investigator
Italian
limit
LMWH
low molecular weight
low-molecular weight heparin
macroscopic
major bleeding
mechanical ventilation
medical intervention
Methylprednisolone
Mortality
mortality rate
Myocardial
Non-invasive
non-invasive ventilation
number
objective
occur
ophthalmic
organ dysfunction
PaO
parallel group
participant
Patient
performed
Pharyngeal swab
Pneumonia
positive
positive pressure
pregnancy test
Presence
Prophylactic
prophylactic dose
Prophylaxis
protocol
random
randomisation
randomised
randomised controlled trial
randomization
Randomized
Randomized controlled trial
Randomly
Ratio
receive
recent
recruited
recruitment
Rectal Bleeding
red blood cell
reduce
reducing
Registered
required
risk of death
Safety
Sample size
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 pneumonia
secondary
secure
severe disease
sick
significantly
sodium
status
steroid
stratified
stroke
study drug
Study protocol
subcutaneously
surgical
syndrome
therapeutic
therapeutic doses
therapy
Treatment
treatment group
unfractionated heparin
Venous Thromboembolism
ventilated patient
Ventilation
website
Weighting
Withdrawal
women
[DOI] 10.1186/s13063-020-04645-z PMC 바로가기 [Article Type] Letter
[DOI] 10.1186/s13063-020-04645-z PMC 바로가기 [Article Type] Letter