A Multistate Toggle Switch Defines Fungal Cell Fates and Is Regulated by Synergistic Genetic Cues다중 상태 토글 스위치는 곰팡이 세포의 운명을 정의하고 시너지 유전 신호에 의해 조절됩니다Research Article Published on 2016-10-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accompany Analysis antagonistic can be used Candida tropicalis Cell cell differentiation cell fate cell type cell types cellular change chromatin Combination determined by ectopic ectopic expression Epigenetic event exhibit expression Fate Formation fungal fungi Gene Expression Gene expression profiles Genetic genetic analysis genetic regulation growth rates higher eukaryotes hybrid increase induce instances lack less master regulator multicellular organism multicellular organisms occurred opposite pathogen phenotypic Regulation stability stable cell stem cell switch switching synergistic to define transcription factor transcription factors transcriptional transcriptionally underlie unique Wor1 yeast [DOI] 10.1371/journal.pgen.1006353 PMC 바로가기 [Article Type] Research Article
Human Management of a Wild Plant Modulates the Evolutionary Dynamics of a Gene Determining Recessive Resistance to Virus Infection야생 식물의 인간 관리는 바이러스 감염에 대한 열성 내성을 결정하는 유전자의 진화 역학을 조절합니다Research Article Published on 2016-08-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele alleles analysed Analysis assays Capsicum coding sequence cultivation Defense Determining Diseases Diversity Dynamics Effect electrostatic Evidence evidence of Evolution full-length functional gene encode Genetic variation genetics host-pathogen interaction host-pathogen interactions Human impairing Infection infection assay infection assays initiation factor Interaction involved loci management mapping Mutation Neutral no evidence of pathogen phenotypic Phylogeny physical plant plant virus plants Population populations Positive selection Potyvirus Proteins R genes recessive recognize resistance resistance gene resistance mutations Result resulting severity supported susceptibility translation initiation triggering Variation variety Viral viruses [DOI] 10.1371/journal.pgen.1006214 PMC 바로가기 [Article Type] Research Article
Molecular epidemiology and evolutionary histories of human coronavirus OC43 and HKU1 among patients with upper respiratory tract infections in Kuala Lumpur, MalaysiaResearch Published on 2016-02-252022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] acute respiratory symptom Analysis Asia assigned Bayesian Betacoronavirus Characteristics China circulating circulation clinical symptom Coronaviruses country detection rate distribution Epidemiology evolutionary dynamics Genetic genetic diversity Genotype genotypes genotypic HCoV-HKU1 HCoV-OC43 HKU1 human coronavirus OC43 Infection isolate Japan Lineage lineages location lowest majority Malaysia molecular Molecular epidemiology Multiplex PCR novel lineage nucleocapsid Patient phenotypic Phylogenetic phylogenetics positive Recombination reported respiratory symptom Result screened sequenced severity SIGN specimen spike gene spike glycoprotein strain supplementary material tested TMRCA tropical upper respiratory infection upper respiratory tract Virus evolution [DOI] 10.1186/s12985-016-0488-4 PMC 바로가기 [Article Type] Research
Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative CrossResearch Article Published on 2015-10-092022-10-28 Journal: PLoS Genetics [Category] Coronavirus, [키워드] Animal host animal model approach assist candidate gene chromosome classical complex contribute contributing to disease disease severity E3 ubiquitin ligase evaluate fiber Genes Genetic genetic data Genetic variation genetics genome region Health highly pathogenic Host host gene identification identify Inflammation Inflammatory response knockout mice loci locus Lung pathology mice microbial mouse model New Noncoding RNAs outcome outcomes pathogen Pathogenesis Pathogens pathology phenotype phenotypic platform populations regulate resource respiratory viruses responses SARS patient SARS-CoV SARS-CoV infection single gene Spread statistical susceptibility loci the disease traits transcriptomic data utility Vascular viral titer virus replication viruses weight loss were used [DOI] 10.1371/journal.pgen.1005504 PMC 바로가기 [Article Type] Research Article
Heterologous Aggregates Promote De Novo Prion Appearance via More than One Mechanism이종 골재는 하나 이상의 메커니즘을 통해 De Novo Prion 모양을 촉진합니다.Research Article Published on 2015-01-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence aggregate aggregates aggregation appear appearance asparagine Cell cells cellular chaperone characteristic Colocalization conformational cytoplasm de novo detect disease domains eukaryotic form Glutamine Heterologous Interaction lack mechanisms molecular MOST neurodegenerative no interaction open overexpressed overexpression pathway periphery phenotypic phenotypic traits physical Polymer prevalent prion promote Protein Proteins PSI required seed stimulated the cell traits vacuole variant while yeast [DOI] 10.1371/journal.pgen.1004814 PMC 바로가기 [Article Type] Research Article
Unisexual Reproduction Drives Meiotic Recombination and Phenotypic and Karyotypic Plasticity in Cryptococcus neoformans단성 생식은 Cryptococcus neoformans에서 감수성 재조합과 표현형 및 핵형 가소성을 유도합니다Research Article Published on 2014-12-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele alleles analyzed Aneuploidy asexual asexual reproduction bisexual reproduction C. neoforman C. neoformans Candida albican Candida albicans characterized chromosomal chromosomal region chromosome chromosome 4 chromosomes collected comparison Cryptococcus Cryptococcus neoforman Cryptococcus neoformans diploid meiotic progeny drive duplication Evidence Evolution examined Frequency fungal fungal pathogen fungi heterozygosity implication initiated loss of heterozygosity MAT locus mating type mating types meiosis meiotic meiotic progeny meiotic recombination mitotic mitotic recombination mixing genetic material occur occurred Pathogenesis Pathogens phenotype phenotypic produced producing progeny quantification Quantitative Recombination recombination frequencies reflected Region regions reported reproduction sexual development sexual reproduction similarity spore spores thought undergo while [DOI] 10.1371/journal.pgen.1004849 PMC 바로가기 [Article Type] Research Article
A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach새로운 MMP12 유전자좌는 게놈 전체 발병 연령 정보 접근 방식을 사용하여 대동맥 죽상경화성 뇌졸중과 연관됩니다Research Article Published on 2014-07-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (atherosclerosis) affected affection age analyses Analysis approach arteries Artery association associations Atherosclerosis atherosclerotic carotid carotid artery chromosome chromosome 11 Conditioning controls covariate demonstrated detect disease disease risk European evaluate Evidence evidence of examined explain Fold change fraction genetic association genetic associations genetic component Genetic predisposition Genetic variant Genome-wide association studies global healthcare GWAS heterogeneity identify IMPROVE increased risk independent information Informed investigated ischaemic stroke large artery lead loci locus Meta-analysis MMP12 mRNA expression novel novel association novel associations overexpressed performed phenotype phenotypic plaque plaques power prevalence rate prevalence rates Regression regression analysis Replication risk significantly small vessel SNP association SNP associations stroke subtype Subtypes the disease variant variants was performed [DOI] 10.1371/journal.pgen.1004469 PMC 바로가기 [Article Type] Research Article
Extensive Diversity of Prion Strains Is Defined by Differential Chaperone Interactions and Distinct Amyloidogenic RegionsPrion 균주의 광범위한 다양성은 차등 샤페론 상호 작용 및 고유한 아밀로이드 생성 영역에 의해 정의됩니다Research Article Published on 2014-05-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] aggregate aggregates aggregation amyloid Analysis canonical chaperone cofactor cofactors complex conformation conformational conformational change consequence Critical determinant disease disease pathology Disease progression Diseases disorders Diversity domain element examined Extensive Factor help Host Hypothesis induce Interaction involved manifestation modulating molecular neurodegenerative pathology phenotypic phenotypic variation prion progression Propagation Protein Proteins provided PSI Region responsible stability strain Strains structures Support These data Transmission unique Variability variant variants Variation variety widespread yeast [DOI] 10.1371/journal.pgen.1004337 PMC 바로가기 [Article Type] Research Article
Heterogeneity in the Frequency and Characteristics of Homologous Recombination in Pneumococcal Evolution폐렴구균 진화에서 상동 재조합의 빈도와 특성의 이질성Research Article Published on 2014-05-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 폐렴구균 감염증, [키워드] a major acquisition adaptive Antibiotic resistance Bacteria bacterial cell Bacterial pathogens bacterium best carried Cell changes children described disease DNA epidemiological evade evaluate events Evolution Genome genomic data greater heterogeneous Homologous recombination Lineage lineages macro mathematical Mathematical models mechanism Meningitis morbidity morbidity and mortality pathogen Pathogens phenotypic pneumococcal pneumococcus Pneumonia pneumoniae Population dynamics populations Recombination respond S. pneumoniae serotype shown species Streptococcus pneumoniae transformation undergo Vaccines [DOI] 10.1371/journal.pgen.1004300 PMC 바로가기 [Article Type] Research Article
Genotypic and Functional Impact of HIV-1 Adaptation to Its Host Population during the North American Epidemic북미 전염병 동안 숙주 인구에 대한 HIV-1 적응의 유전형 및 기능적 영향Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate adaptation analyzed Antiviral antiviral immunity assessment average Boston cellular immunity changes in characterized circulating codon Cohort Consensus consequence detectable enrolled Epidemic ERAS escape mutation Evolution exhibiting explain Frequency functional Gag greater HIV HIV-1 HLA Host immune immune escape mutation immune escape mutations Impact implication in vitro Increases individual information median medians Mutation New York North North America Patient persistence phenotypic Phylogeny polymorphism Polymorphisms Population Protective Protein reconstructed reduce remained replication capacity residue Result San Francisco selected sequence specimen Spread subsequent suggested Support the epidemic the median Transmission unlikely Viral viral fitness Viral proteins virus [DOI] 10.1371/journal.pgen.1004295 PMC 바로가기 [Article Type] Research Article