Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane DiterpenesArticle Published on 2020-10-182022-10-30 Journal: Marine Drugs [Category] Coronavirus, MERS, SARS, [키워드] acute respiratory syndrome amide amides/esters antagonist antagonists assays bioactive diterpenes biological activity cellular Compound coronavirus COVID-19 Critical determinant diterpene flexible Infection Labdane labdane scaffold novel nucleus organism oxidized pharmacological pharmacological target plants receptor respiratory diseases SARS-CoV-2 sclareolide selective Structure-activity relationships synthesis terrestrial TRPV1 TRPV4 TRPV4 channel validation variety were assessed widespread [DOI] 10.3390/md18100519 PMC 바로가기 [Article Type] Article
Identification of Novel SARS-CoV-2 Drug Targets by Host MicroRNAs and Transcription Factors Co-regulatory Interaction Network Analysis호스트 MicroRNA 및 전사 인자 공동 조절 상호 작용 네트워크 분석에 의한 새로운 SARS-CoV-2 약물 표적 식별Genetics Published on 2020-10-142022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting Analysis Anti-viral anti-viral activity Anti-viral drugs anti-viral miRNAs approach biological processes coronavirus DNMT1 downregulated drug drug target Epigenetic epigenetic modification Factor FIVE GDF1 Gene Expression gene regulatory network Genes HMOX1 Host host gene host miRNA host response host responses host–microRNA hsa-miR-1-3p hsa-miR-15a-5p hsa-miR-17-5p hsa-miR-199a-3p hsa-miR-20a-5p hsa-miR-429 hub genes human miRNA human miRNAs identification identify immune system include Interaction interferon involved ITGB1 mechanism miRNA miRNAs Modification modulation network novel other respiratory virus Other respiratory viruses PLAT Protein–protein interaction Regulatory regulatory network reported repression respiratory Respiratory disease respiratory diseases SARS-CoV-2 SARS-CoV-2 genome severe acute respiratory syndrome Coronavirus T-cell differentiation target TFS transcription factor transcription factors understanding unique virulence virus virus infection virus replication viruses [DOI] 10.3389/fgene.2020.571274 PMC 바로가기 [Article Type] Genetics
Nebulized ivermectin for COVID-19 and other respiratory diseases, a proof of concept, dose-ranging study in ratsArticle Published on 2020-10-132022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] adipose adjusted Administered alveolar Anomaly antiparasitic drug assigned Biochemistry C max changes in Concentration conducted control group COVID-19 detectable dose drug delivery Drug development Efficacy enzyme experiment female females full blood count groups High-dose histological in vitro Ivermectin ivermectin dose low-dose lower dose lung lung tissue male nebulized Particle pharmacokinetic plasma plasma concentration post intervention Preclinical research Randomly RAT reached recent reduction required respiratory diseases RNA viruses Safe SARS-CoV-2 replication Seven subject therapy toxicology was determined [DOI] 10.1038/s41598-020-74084-y PMC 바로가기 [Article Type] Article
Contact Tracing during Coronavirus Disease Outbreak, South Korea, 2020Expedited Published on 2020-10-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus disease analyzed Contact Contact tracing coronavirus disease COVID-19 household contacts likelihood measure Patient Pneumonia Protective reduce reported respiratory diseases SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 social distancing South Korea tracing Transmission viruses zoonoses [DOI] 10.3201/eid2610.201315 PMC 바로가기 [Article Type] Expedited
Coronavirus Disease among Persons with Sickle Cell Disease, United States, March 20–May 21, 2020Expedited Published on 2020-10-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] Affect African American black coronavirus coronavirus disease COVID-19 died disease hemoglobin Hospitalized organ damage Person reduced reported respiratory diseases SARS-CoV-2 SCD severe acute respiratory syndrome coronavirus 2 Sickle Sickle cell disease the United State United States viruses zoonoses [DOI] 10.3201/eid2610.202792 PMC 바로가기 [Article Type] Expedited
Culture-Competent SARS-CoV-2 in Nasopharynx of Symptomatic Neonates, Children, and AdolescentsExpedited Published on 2020-10-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus disease acute respiratory syndrome Adolescent adolescents children coronavirus coronavirus disease COVID-19 in vitro Neonates respiratory diseases SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Switzerland symptomatic Transmission viral shedding virus viruses zoonoses [DOI] 10.3201/eid2610.202403 PMC 바로가기 [Article Type] Expedited
Effect of COVID-19 on Tuberculosis Notification, South KoreaExpedited Published on 2020-10-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus disease Adequate Bacteria coronavirus disease COVID-19 diagnose Effect highest Infectious disease measure notification Prevent raised respiratory diseases SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 significantly South Korea Tuberculosis tuberculosis and other mycobacteria viruses zoonoses [DOI] 10.3201/eid2610.202782 PMC 바로가기 [Article Type] Expedited
Cardiothoracic surgery during the Covid-19 pandemic: Perioperative care, safety, and surgical resultsArticle Published on 2020-10-012023-07-06 Journal: Journal of cardiac surgery [Category] SARS, [키워드] cardiovascular diseases COVID-19 respiratory diseases Surgical procedures [DOI] 10.1111/jocs.14857 PMC 바로가기
With Corona Outbreak: Nature Started Hitting the Reset Button GloballyPublic Health Published on 2020-09-242022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] Button caused contagious Corona coronavirus COVID-19 environmental health Environmental pollution Health healthcare help impacts Local lockdown measure Nature offer organizations other disease pandemic Pathways positive provided representing respiratory diseases SARS virus Spread Started virus [DOI] 10.3389/fpubh.2020.569353 PMC 바로가기 [Article Type] Public Health
COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?Pharmacology Published on 2020-09-232022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] adjuvant Allium benefit/risk assessment Clinical data collected conditions coronavirus (2019-nCoV) COVID-19 COVID-19 pandemic COVID-19 patient current disease drug drugs Echinacea Efficacy and safety EMA Eucalyptus globulus evaluated Evidence expected Fever flu Frame glycyrrhiza healthy Hedera helix Herbal herbal medicine herbal medicines IMPROVE include indicated Magnolia Medicine Mikania Mild offer Paracetamol Patient Pelargonium positive Preclinical Prevent recommendation respiratory diseases Result safety margin Sambucus selected Self-isolation Self-management Symptom the WHO therapeutic approaches Treatment underlying conditions while widespread Zingiber [DOI] 10.3389/fphar.2020.581840 PMC 바로가기 [Article Type] Pharmacology