Pregnant women with severe or critical coronavirus disease 2019 have increased composite morbidity compared with nonpregnant matched controlsMulticenter Study Published on 2021-05-012023-07-12 Journal: American journal of obstetrics and gynecology [Category] SARS, [키워드] coronavirus Critical disease disease course intensive care intubation Maternal morbidity pandemic Pregnancy Preterm birth Respiratory distress syndrome Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 severe disease [DOI] 10.1016/j.ajog.2020.11.022 PMC 바로가기 [Article Type] Multicenter Study
Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic면역 체계 강화에 Nagella sativa(블랙 커민)의 잠재적인 영향: COVID-19 전염병을 늦추기 위한 희망Review Published on 2021-05-012022-08-31 Journal: Phytomedicine : international journal of phytother [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory distress syndrome Anti-inflammatory antioxidant ARDS benefit black Black seed component components coronavirus COVID-19 COVID-19 pandemic COVID-19 patient Critical Cytokines disease severity Effect Evidence FDA approved Drugs human body immune immune modulation immune regulation immune response immune system immunomodulation indicated infected with COVID-19 intensive care intensive care unit modulation molecular molecular docking Molecular docking study Mortality Nagella sativa New coronavirus Nigella Sativa Nigellidine Obstructive pandemic pathophysiology Patient Potential pro-inflammatory cytokine pro-inflammatory cytokines provided respiratory respiratory disorders respiratory distress Respiratory distress syndrome severe cases severity Symptom the disease thymoquinone treat Treatment Vaccine α-hederin α-hederin. [DOI] 10.1016/j.phymed.2020.153277 PMC 바로가기 [Article Type] Review
Treating exuberant, non-resolving inflammation in the lung; Implications for acute respiratory distress syndrome and COVID-19폐의 무성하고 해결되지 않는 염증을 치료합니다. 급성호흡곤란증후군과 코로나19에 대한 시사점Review Published on 2021-05-012022-09-11 Journal: Pharmacology & therapeutics [Category] 임상, [키워드] acute respiratory distress acute respiratory distress syndrome added aetiology age anti-inflammatory agent ARDS COVID-19 death driven by driving drug effective Efficacy elevated highlight Host immune response immune responses impairing increasing age Infection Inflammation inflammatory pathway inflammatory pathways Inflammatory response inhibit innate immune response lack likelihood lung; older patients p38 MAP kinase. pathogen Pathogens pathway Prevalence regimen respiratory distress Respiratory distress syndrome SARS-CoV-2 seasonal flu suggested susceptible syndrome the disease treating Treatment Vaccine vaccine efficacy while [DOI] 10.1016/j.pharmthera.2020.107745 PMC 바로가기 [Article Type] Review
High value of mid-regional proadrenomedullin in COVID-19: A marker of widespread endothelial damage, disease severity, and mortalityCOVID-19에서 중부 프로아드레노메둘린의 높은 가치: 광범위한 내피 손상, 질병 중증도 및 사망률의 지표Article Published on 2021-05-012022-08-31 Journal: Journal of medical virology [Category] Fulltext, MERS, 바이오마커, 진단, [키워드] Acute cardiac injury Acute kidney injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADM adrenomedullin ARDS best cardiac injury characteristic clinically coronavirus COVID-19 cut-off value disease severity Disruption dysfunction endothelial damage enrolled evaluate evaluated high mortality identify inflammatory status Intensive Ischemic Stroke laboratory data lead Liver damage marker Mortality mortality risk MR-proADM Multiorgan dysfunction multiple organ dysfunction multiple organ dysfunction syndrome organ organ dysfunction syndrome Patient patients died presenting respiratory respiratory distress Respiratory distress syndrome responsible risk SARS virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 Septic shock severe acute respiratory syndrome Coronavirus significantly higher stroke syndrome Therapeutic approach vascular leakage widespread [DOI] 10.1002/jmv.26676 PMC 바로가기 [Article Type] Article
Krebs von den Lungen 6 (KL-6) as a marker for disease severity and persistent radiological abnormalities following COVID-19 infection at 12 weeksKrebs von den Lungen 6(KL-6)은 12주에 COVID-19 감염 후 질병 중증도 및 지속적인 방사선 이상에 대한 마커입니다.Observational Study Published on 2021-04-292022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 바이오마커, 임상, [키워드] abnormal CT scans abnormality absence acute COVID-19 acute infection acute respiratory distress acute respiratory distress syndrome Admission age ARDS association Asymptomatic baseline breathlessness cell injury clinical manifestation clinical manifestations Clinical severity Cohort Complication convalescent correlation COVID-19 infection CT scan CXR deconditioning determine disease severity Dyspnoea epithelial cell fibrosis finding Follow up appointment glycoprotein help hospital include Infection initial Injury Lung fibrosis male marker median medium mucin no significant difference observational study on admission oxygen Patient patients persistence presence or absence proportion Prospective pulmonary epithelial cell radiological abnormalities radiological abnormality Research question respiratory distress Respiratory distress syndrome Result severity significant difference significantly higher syndrome with COVID-19 [DOI] 10.1371/journal.pone.0249607 PMC 바로가기 [Article Type] Observational Study
Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational studyObservational Study Published on 2021-04-222022-10-04 Journal: Infection [Category] MERS, SARS, 임상, [키워드] 95% CI acute respiratory distress Adequate Admission adult COVID-19 patient affected analysed Artificial respiration Care Characteristics clinical Clinical course Cohort concentrations Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 nucleic acid testing described disease trajectories duration of hospitalisation duration of symptom enrolled European First wave Healthcare systems hospitalised hospitalised COVID-19 patient hypertension identify IMV Invasive mechanical ventilation IQR knowledge less management mechanical ventilation Patient patients per day prospective observational study Prospective Study required resource Respiratory distress syndrome Result risk factor SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe disease short duration strained supplementary material Symptom Symptom assessment syndrome the SARS-CoV-2 Viral concentration viral kinetics Viral load Virological [DOI] 10.1007/s15010-021-01594-w PMC 바로가기 [Article Type] Observational Study
Increased Serum Levels of Soluble TNF-α Receptor Is Associated With ICU Mortality in COVID-19 Patients가용성 TNF-α 수용체의 증가된 혈청 수준은 COVID-19 환자의 ICU 사망률과 관련이 있습니다Immunology Published on 2021-04-222022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus Admission age ARDS Biomarker cause Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 disease cytokine Cytokine storm death determinant determinants disease disease severity ELISA ESR Future greater healthy control healthy subjects ICU ICU patient ICU Patients Increased intensive care intensive care unit Iran laboratory-confirmed Laboratory-confirmed COVID-19 Level Mild Mortality non-ICU non-ICU patient non-ICU patients objective Older outcome Patient positively correlated receptor recruited respiratory respiratory distress Respiratory distress syndrome Result SARS-CoV-2 serum Serum level serum levels severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe COVID-19 disease severe COVID-19 patient severe COVID-19 patients severe disease significantly higher soluble TNF-α subject syndrome Tehran the healthy TNF-α TNF-α Ventilation [DOI] 10.3389/fimmu.2021.592727 PMC 바로가기 [Article Type] Immunology
A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trialSARS-CoV-2 유발 급성 호흡곤란 증후군에 대한 정맥내 혈장 정제 알파-1 항트립신의 무작위 이중 맹검 위약 대조 파일럿 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-192022-09-10 Journal: Trials [Category] 임상, [키워드] 24 hours active malignancy acute kidney Acute kidney injury acute respiratory distress syndrome addition Administered administration adverse event adverse events AEs age Alpha alpha-1 antitrypsin Amendment Anti-viral Antibiotics anticipated antitrypsin antivirals approval approved ARDS ARMS authority bacterial pneumonia baseline Berlin criteria blinded to treatment Blinding BMI body weight Cancer changes in Child-Pugh score chloride Chronic kidney disease chronic liver disease circulating class clinical Clinical outcome clinical trial Combination commenced Committee comparator Complete conducted Consent Controlled trial correction COVID-19 Culture cytokine level cytokine levels Data collection defined determine Diagnosis diagnosis of ARDS dialysis dissemination DNAR double-blind Echocardiogram Effect Effectiveness elapsed element ELISA enrolled EudraCT excluded exclusion exclusion criteria facilitate Follow-up followed by for inclusion group Health Products regulatory Authority hospital Hospital admission hypertension ICU IgA deficiency IL-10 IL-1β IL-6 IL-8 incidence inclusion criteria individual information intensive care unit intensive care units interim analysis interleukin interleukin-10 interleukin-1β interleukin-6 interleukin-8 interpreter Intervention intravenous intravenous infusion intravenously invasive investigational medicinal product investigator Ireland Kidney disease Laboratory laboratory-confirmed life Local maintain major trauma malignancy mandatory marker mechanical ventilation Microscopy moderate moderate to severe Mortality Non-invasive non-invasive mechanical ventilation non-invasive ventilation number objective occur Organ failure outcome outcome measure PaO participant Patient patient recruitment patients with moderate PCR-confirmed Phase 2 physician Placebo placebo-controlled plasma plasma analysis plasma concentration plasma concentrations pregnant preparation product protocol provided Pulmonary embolism pulmonary hypertension purified Radiographic randomisation randomisation list randomised randomised controlled trial rationale readmission REC receiving receptor recruited recruitment reduce Regulatory removal renal renal replacement therapy replacement therapy reported required Research Research Ethics Research Ethics Committee research nurse research nurses respiratory respiratory distress Respiratory distress syndrome resulting Resuscitation SAE SAEs Sample size SARS-CoV-2 secondary secondary bacterial pneumonia Secondary objective Secondary objectives Secondary outcomes secretion Sequential Organ Failure Assessment Serious Adverse Event Serious Adverse Events severe ARDS Shock single dose skin cancer Sodium chloride SOFA Standard statistician stratified study participation Study protocol subject submitted supplementary material Support sustained TNF TNF-α Tolerability trauma Treatment treatment allocation Trial trial protocol Trial registration vasopressors ventilator verbal Version Volume website WHO Withdrawal writing [DOI] 10.1186/s13063-021-05254-0 PMC 바로가기 [Article Type] Letter
Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort studyCOVID-19 유무에 관계없이 ICU 환자의 숙주 내피, 상피 및 염증 반응의 비교: 전향적 관찰 코호트 연구Observational Study Published on 2021-04-192022-09-11 Journal: Critical Care [Category] MERS, 바이오마커, 임상, [키워드] Acute kidney injury acute phase acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amyloid A angiopoietin biological pathway Biomarker Blood both groups cause cell injury characteristic collected Concentration coronavirus COVID-19 Critical Critical illness Critically ill demographics diagnose diagnoses end products endothelial Endothelial dysfunction enrolled epithelial epithelial cell evaluate followed by groups Host host response ICU admission ICU patient ICU Patients in both group in-hospital mortality Inflammation Inflammatory biomarker Inflammatory response interleukin interleukin 6 Invasive mechanical ventilation involved marker Mortality Necrosis Non-COVID-19 non-COVID-19 patient Non-COVID-19 patients not different Pathways Patient plasma biomarker Pneumonia positive proportion prospective observational cohort Protein receptor respiratory respiratory distress Respiratory distress syndrome Respiratory failure Result resulting SAA SARS-CoV-2 SARS-COV-2 infection Sepsis serum amyloid severe acute respiratory syndrome Coronavirus severe COVID-19 significantly higher significantly lower sTNFR study enrollment supplementary material syndrome target targets Therapeutics Tumor tumor necrosis tumor necrosis factor Viral viral infection while [DOI] 10.1186/s13054-021-03547-z PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 Serum Neutralization Assay: A Traditional Tool for a Brand-New VirusSARS-CoV-2 혈청 중화 분석: 새로운 바이러스에 대한 전통적인 도구Article Published on 2021-04-102022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome Algorithm Analysis anti-SARS-CoV-2 IgG antibody Antibody-mediated immunity automated characteristic collected convalescent COVID-19 patient convalescent plasma correlation COVID-19 patients cutoff value determine develop Donor donors FIVE gold gold standard IgA IgM Immunity individual ineligible Laboratory large sample live SARS-CoV-2 Microneutralization test MNT MONITOR NAb NAb titer NAbs Neutralizing antibodies neutralizing antibody Patient plasma presenting protective immunity receiver receiver operating characteristic respiratory distress Respiratory distress syndrome ROC SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 NAb serology Serum Neutralization serum sample serum samples SmaRT symptom onset syndrome tested titers Traditional vaccinated individuals Viral Viral antigen viral antigens were measured [DOI] 10.3390/v13040655 PMC 바로가기 [Article Type] Article