Educational Attainment Decreases the Risk of COVID-19 Severity in the European Population: A Two-Sample Mendelian Randomization Study교육 성취는 유럽 인구의 COVID-19 심각성 위험 감소: 2표본 멘델식 무작위 배정 연구Public Health Published on 2021-06-032022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 유전자 메커니즘, [키워드] 95% confidence interval Analysis approach association attainment condition COVID-19 COVID-19 Host Genetics Initiative COVID-19 severity data set data sets decrease educational attainment epidemiological European European population Evidence evidence of Genetic genetic association Genome-wide association studies Genome-wide association study GWAS GWASs increase in initiative instrumental variable instrumental variables investigated lower risk measure mechanism mechanisms mendelian randomization MR study observational studies observational study Odds ratio outcome participant physical physical conditions polymorphism reported risk risk of COVID-19 SARS-CoV-2 Science Sensitivity analyses sensitivity analysis severity severity of COVID-19 significantly single-nucleotide Single-nucleotide polymorphisms SNP SNPs socioeconomic status Standard deviation was obtained was performed years of schooling [DOI] 10.3389/fpubh.2021.673451 PMC 바로가기 [Article Type] Public Health
Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization studyCOVID-19 Host Genetics Initiative의 비타민 D 및 COVID-19 감수성 및 심각성: 멘델식 무작위 배정 연구Research Article Published on 2021-06-012022-08-13 Journal: PLoS Medicine [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] 2-sample MR 25-hydroxy vitamin D 25OHD 25OHD level 25OHD levels 95% CI analyses Analysis association associations circulating confounder confounders confounding variables Control control group control groups controlled trials controls COVID-19 COVID-19 case COVID-19 cases COVID-19 Host Genetics Initiative COVID-19 susceptibility deficiency described determined by ecological Ecological studies European Evidence General population Genetic genetic determinant genetic determinants genetic evidence genetic instrument genetic instruments Genetic variant genetic variants Genome-wide association study Guillaume GWAS GWASs had no horizontal pleiotropy Hospitalization IMPROVE in some in vitro Increased individual individuals with COVID-19 initiative instrument bia instrumental variables inverse-weighted MR Laboratory testing large-scale vitamin D randomized trials limit logarithmic scale mendelian randomization Mendelian randomization studies Mendelian randomization study meta-analytic methods observational studies observé Odds ratio Other outcome outcomes participant Population predicted PROTECT provide provided Randomized controlled trial Randomized controlled trials randomized trials rationale reduce reflected removal researcher risk SARS-CoV-2 positivity Sensitivity analyses sensitivity analysis severe disease severity Standard deviation Support supported susceptibility therapeutic therapy trials UK biobank variant variants Vitamin D vitamin D deficiency vitamin D level vitamin D levels Vitamin D Mendelian randomization vitamin D Mendelian randomization studies Vitamin D supplementation vitamin D supplementation randomized trials was determined were used with COVID-19 worsened [DOI] 10.1371/journal.pmed.1003605 PMC 바로가기 [Article Type] Research Article
Biomarkers and outcomes of COVID-19 hospitalisations: systematic review and meta-analysisCOVID-19 입원의 바이오마커 및 결과: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-06-012022-08-31 Journal: BMJ evidence-based medicine [Category] MERS, SARS, 바이오마커, [키워드] 2019-nCoV 95% CI Admission Alanine alanine aminotransferase ALT aspartate Aspartate aminotransferase association AST Biomarker Biomarkers C reactive protein clinical decision Composite Consensus coronavirus COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity creatine creatine kinase creatinine Critical Critical care CRP D-dimer Decision making Diseases elevated English evaluate evidence-based practice forest plot forest plots global health healthcare heterogeneity high-risk patient High-risk patients higher risk hospitalised patient Hospitalised patients IMPROVE In-hospital include independent Infectious disease infectious disease medicine Infectious diseases intensive care intensive care unit admission Invasive mechanical ventilation Laboratory laboratory findings Lactate lactate dehydrogenase LDH lymphocyte lymphopenia management medical subject heading Medical Subject Headings meta-analyses Meta-analysis MOOSE Mortality nCoV observational studies observational study outcome outcomes oxygen oxygen saturation pandemic PCT Platelets procalcitonin Prognosis Publication bia publication bias Random-effects models resource resources SARS-CoV-2 selected sensitivity analysis severe disease Severity of disease systematic review thrombocytopenia Web of Science were assessed [DOI] 10.1136/bmjebm-2020-111536 PMC 바로가기 [Article Type] Meta-Analysis
Aligning SARS-CoV-2 indicators via an epidemic model: application to hospital admissions and RNA detection in sewage sludge전염병 모델을 통한 SARS-CoV-2 지표 정렬: 병원 입원 및 하수 슬러지 RNA 검출에 적용Article Published on 2021-06-012022-09-11 Journal: Health care management science [Category] SARS, 치료기술, [키워드] 95% confidence interval Admission Analysis average Concentration coronavirus COVID-19 COVID-19 hospital admissions direction distribution Epidemic epidemic curve Epidemic indicators Epidemiology hospital Hospital admission Hospital admissions Hospitalization incidence Infection Inference inferences likelihood Maximum likelihood outbreak probability distribution probability distributions Probability model public health repeated reproductive researcher rising risk of infection RNA RNA concentration RNA concentrations SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 RNA sensitivity analysis sewage Sewage sludge Sewage sludge viral RNA concentration shape shown time lag total population translate Transmission dynamics Transmission model Viral RNA wastewater wastewater epidemiology [DOI] 10.1007/s10729-020-09525-1 PMC 바로가기 [Article Type] Article
Serial markers of coagulation and inflammation and the occurrence of clinical pulmonary thromboembolism in mechanically ventilated patients with SARS-CoV-2 infection; the prospective Maastricht intensive care COVID cohortResearch Published on 2021-05-312022-10-29 Journal: Thrombosis Journal [Category] COVID-19, [키워드] addition adjusted age analysed Anticoagulants average Biomarker body mass index C-reactive protein cardiac thrombus clinical Coagulation Cohort Computed tomography Concentration COVID COVID-19 CRP CTPA D-dimer eight excluded ferritin fibrinogen hypothesise incidence Inflammation intensive care Linear regression model Lower marker mechanically ventilated patient Occurrence on mechanical ventilation outcome Patient positive Prospective Study Protein pulmonary angiography Pulmonary embolism pulmonary thrombosis Result risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient sensitivity analysis Sex significantly statistical significance supplementary material therapy Thromboembolism thrombus formation tissue plasminogen activator vessels were measured [DOI] 10.1186/s12959-021-00286-7 PMC 바로가기 [Article Type] Research
Modelling the Transmission Dynamics of COVID-19 in Six High-Burden CountriesResearch Article Published on 2021-05-272022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] Canada children China compartmental model correlation coefficient country COVID-19 COVID-19 case COVID-19 disease Critical death Dynamics highest identify impacted incidence Infection information Italy Ministry of Health Older opposite pandemic parameter Prevalence provided recommendation reported sensitivity analysis Spain Spread susceptibility susceptible Transmission transmission rate USA [DOI] 10.1155/2021/5089184 PMC 바로가기 [Article Type] Research Article
Modelling the Transmission Dynamics of COVID-19 in Six High-Burden CountriesResearch Article Published on 2021-05-272022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] Canada children China compartmental model correlation coefficient country COVID-19 COVID-19 case COVID-19 disease Critical death Dynamics highest identify impacted incidence Infection information Italy Ministry of Health Older opposite pandemic parameter Prevalence provided recommendation reported sensitivity analysis Spain Spread susceptibility susceptible Transmission transmission rate USA [DOI] 10.1155/2021/5089184 PMC 바로가기 [Article Type] Research Article
Systemic Corticosteroid Administration in Coronavirus Disease 2019 Outcomes: An Umbrella Meta-Analysis Incorporating Both Mild and Pulmonary Fibrosis–Manifested Severe DiseasePharmacology Published on 2021-05-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] administration adverse event AEs Analysis association benefit caution Clinical improvement Clinical practice Confidence intervals coronavirus coronavirus disease Corticosteroid Corticosteroids COVID-19 COVID-19 patient critically ill/pulmonary fibrosis manifested database dose Effect effect size Efficacy Egger’s test eligible evaluated Evidence fixed hospital Hospital stay Hospitalization ICU intensive care intervals mechanical ventilation Mortality Negative conversion outcome Patient pulmonary Random-effects models reduction in mortality risk reduction searched sensitivity analysis systemic Treatment UMBRELLA umbrella meta-analysis virus clearance [DOI] 10.3389/fphar.2021.670170 PMC 바로가기 [Article Type] Pharmacology
The epidemiological impact of the NHS COVID-19 app Research Published on 2021-05-122022-10-05 Journal: Nature [Category] 치료법, [키워드] 95% confidence interval complementary Contact Contact tracing COVID-19 COVID-19 pandemic England epidemiological event Evidence fraction help increase in index case individual Local National Health Service NHS Population positive Prevent public health reduced remained SAR secondary attack rate sensitivity analysis Spread statistical statistical analysis Support supported Symptom tested the disease total population Vaccines was used [DOI] 10.1038/s41586-021-03606-z [Article Type] Research
COVID-19 and air pollution in Vienna—a time series approachOriginal Article Published on 2021-05-062022-10-29 Journal: Wiener Klinische Wochenschrift [Category] COVID-19, SARS, [키워드] Acute effects Analysis applied approach association Concentration coronavirus disease COVID-19 COVID-19 mortality death defined implication Infection infection risk infectious agents Interaction irritant gas logarithm Mortality nitrogen dioxide not affect Particle Particulate matter per day performed Poisson regression pollutant positively correlated retrieved risk risk of infection SARS-CoV-2 sensitivity analysis Vienna [DOI] 10.1007/s00508-021-01881-4 PMC 바로가기 [Article Type] Original Article