Retrospective analysis of severe COVID-19 pneumonia patients treated with lopinavir/ritonavir: A comparison with survivor and non-survivor patientsOriginal Research Published on 2020-12-212022-10-28 Journal: Southern African Journal of Infectious Diseases [Category] COVID-19, [키워드] 1.26 95% confidence interval advanced age affecting age analysed Analysis arrhythmia Aspartate transaminase AST C-reactive protein C-reactive protein (CRP changes in comorbid disease Comorbidity congestive heart failure Coronary artery disease COVID-19 D-dimer determine diabete diabetes disease Efficacy Factor female hypertension increased mortality Laboratory lactate dehydrogenase LDH Lopinavir male Mortality neutrophil non-survivor Patient patients patients treated Result Ritonavir Severe COVID-19 pneumonia severe pneumonia smoking statistically survivor treated treatment for COVID-19 [DOI] 10.4102/sajid.v35i1.233 PMC 바로가기 [Article Type] Original Research
SARS-CoV-2 Is Not Detected in the Cerebrospinal Fluid of Encephalopathic COVID-19 PatientsNeurology Published on 2020-12-112022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] ACE2 receptor addition Brain cell type Central nervous system cerebrospinal fluid COVID-19 COVID-19 patient CSF diagnosed diagnostic domain Encephalopathy etiology Evidence expressed host cells Infection manifestation mechanism mechanisms mRNA nasopharyngeal Nasopharyngeal swab neurologic novel coronavirus SARS-CoV-2 Patient positive required RNA-seq dataset robust RT-PCR SARS-CoV-2 SARS-COV-2 infection Severe COVID-19 pneumonia TMPRSS2 transmembrane serine protease unlikely viral entry viral infection virus [DOI] 10.3389/fneur.2020.587384 PMC 바로가기 [Article Type] Neurology
The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome더 나쁜 결과를 초래할 수 있는 심각한 COVID-19 폐렴에서 조절되지 않는 선천성 면역 반응Controlled Clinical Trial Published on 2020-12-032022-08-13 Journal: Journal of Translational Medicine [Category] MERS, SARS, 임상, [키워드] acute respiratory distress syndrome Analysis baseline CCL20 CCL5 Characteristics classical clinical coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL10 cytokine cytokine response Cytokines dysregulated dysregulated immune response enrolled G-CSF GM-CSF IL-10 IL-15 IL-1β IL-2 IL-6 IL-8 immune modulation immune response Immunopathogenesis Inflammatory cytokine Inflammatory cytokines innate immune response intensive care mechanical ventilation multivariate regression analysis Non-COVID-19 non-COVID-19 and COVID-19 patients non-COVID-19 patient Non-COVID-19 patients outcome outcomes plasma plasma concentration plasma concentrations Pneumonia Principal component principal component analysis required respiratory respiratory severity Result severe COVID-19 Severe COVID-19 pneumonia severe pneumonia significantly single center T cell T cell phenotype T-cell exhaustion target TGF-β therapeutic therapeutic targets TNF-α unique [DOI] 10.1186/s12967-020-02646-9 PMC 바로가기 [Article Type] Controlled Clinical Trial
Observational study of therapeutic bronchoscopy in critical hypoxaemic ventilated patients with COVID-19 at Mediclinic Midstream Private Hospital in Pretoria, South AfricaPulmonology Published on 2020-12-012022-10-28 Journal: African Journal of Thoracic and Critical Care Medicine [Category] COVID-19, [키워드] airway average caused COVID-19 Critical demonstrated Diagnosis diagnostic enrolled evaluate FFB hypoxaemia hypoxaemic hypoxaemic respiratory failure inflammatory parameter intensive care Laboratory management mechanical ventilation mechanically ventilated patient Midstream objective observational study pathophysiological Patient phenotype plugs Private Respiratory failure Respiratory tract diseases respond Result Severe COVID-19 pneumonia significantly South Africa therapeutic Therapeutic bronchoscopy therapy Ventilated ventilated patient ventilated patients Viral; Lung Diseases. Parasitic Viral; Pneumonia with COVID-19 [DOI] 10.7196/AJTCCM.2020.v26i4.119 PMC 바로가기 [Article Type] Pulmonology
Lung Ultrasound in Severe COVID-19 Pneumonia in the Sub-Intensive Care Unit: Beyond the Diagnostic PurposeCase report Published on 2020-11-272022-10-05 Journal: Respiratory Medicine Case Reports [Category] 진단, [키워드] arterial blood gase assist clinical evolution Clinical management Clinical sign conditions consolidation COVID-19 CPAP diagnostic employment lung failure Lung ultrasound management non-invasive ventilation Pneumonia severe COVID-19 disease Severe COVID-19 pneumonia the timing Ultrasound worsening [DOI] 10.1016/j.rmcr.2020.101307 [Article Type] Case report
COVID-19 infection: epidemiological, clinical, and radiological expression among adult populationResearch Published on 2020-11-252022-10-31 Journal: The Egyptian Journal of Radiology and Nuclear Medicine [Category] COVID-19, [키워드] Admission age backbone Bilateral both group chest pain Computed tomography Coronavirus infection COVID-19 COVID-19 infection COVID-19 pandemic D-dimer D-dimer level Diagnosis diagnostic Dyspnea elevated epidemiological evaluated expression Fever Follow-up Gender GGOs Ground glass opacity Home isolation Hospitalization HRCT hypertension ICU Increasing intensive care Laboratory Lung fibrosis male negative correlation Non-severe case Outbreaks outcome oxygen saturation oxygen support Patient Pneumonia polymerase chain radiological Result risk factor RT-PCR sensitivity Serum ferritin Severe case Severe COVID-19 pneumonia severe group severity Significant smoking transcriptase Treatment troponin levels [DOI] 10.1186/s43055-020-00341-9 PMC 바로가기 [Article Type] Research
A Risk Prediction Model for Evaluating the Disease Progression of COVID-19 PneumoniaMedicine Published on 2020-11-052022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome age Algorithm Analysis caused China Cohort cohorts Comorbidities coronavirus coronavirus disease COVID 19 COVID-19 CREA diabetes Disease progression enrolled Epidemic evaluate Evaluating Factor Fever help hospital hypertension identify Infection Laboratory LDH Logistic Logistic regression men Meta-analysis Model neutrophil count Patient Pneumonia prediction progression risk risk factor Risk prediction model SARS-CoV2 Severe COVID-19 pneumonia shown significantly sSARS—CoV-2 table the disease the median validation cohort validation cohorts was performed with COVID-19 women Wuhan [DOI] 10.3389/fmed.2020.556886 PMC 바로가기 [Article Type] Medicine
Clinical features and multidisciplinary treatment outcome of COVID-19 pneumonia: A report of three casesCase report Published on 2020-11-012022-10-05 Journal: Journal of the Formosan Medical Association = Taiw [Category] SARS, 치료법, [키워드] acute respiratory syndrome Antiviral ARDS bronchitis caused clinical Clinical outcome Comorbidities coronavirus COVID pneumonia COVID-19 COVID-19 patient COVID-19 pneumonia patient diabete diagnosed feature female global public health highlight male moderate mortality risk factors Multidisciplinary therapeutic approach novel coronavirus disease pandemic Patient Pneumonia Psychological intervention SARS-CoV-2 Severe case Severe COVID-19 pneumonia Support the patient Therapeutic approach Treatment Treatment outcome [DOI] 10.1016/j.jfma.2020.04.008 [Article Type] Case report
Can steroids reverse the severe COVID-19 induced “cytokine storm”?Observational Study Published on 2020-11-012022-10-05 Journal: Journal of medical virology [Category] 임상, [키워드] acute lung injury acute respiratory distress administration Admission ARDS Can case sery characterized Clinical outcome coronavirus disease Corticosteroid Corticosteroids Course COVID-19 COVID-19 patient cytokine Cytokine storm discharged Evidence hospital hyper-inflammatory syndrome. Hyperreactivity immune IMPROVE intensive care intubation Laboratory median Patient Proinflammatory cytokine reported resolved resulting severe COVID-19 Severe COVID-19 pneumonia severe pneumonia steroid syndrome treated viral clearance [DOI] 10.1002/jmv.26165 PMC 바로가기 [Article Type] Observational Study
Outcome of early-stage combination treatment with favipiravir and methylprednisolone for severe COVID-19 pneumonia: A report of 11 cases중증 코로나19 폐렴에 파비피라비르·메틸프레드니솔론 초기 병용치료 결과: 11건 보고Case Reports Published on 2020-11-012022-09-11 Journal: Respiratory investigation [Category] SARS, 치료법, 치료제, [키워드] Blood oxygen saturation Clinical outcome Combination combination treatment coronavirus disease Coronavirus disease 2019 Corticosteroids COVID-19 COVID-19 pneumonia Critical case critical cases Favipiravir Health Organization indicated management Methylprednisolone novel Novel coronavirus novel coronavirus disease Novel coronavirus disease 2019 oxygen Oxygen administration oxygen supplementation Patient required room air Severe case severe cases severe COVID-19 Severe COVID-19 pneumonia severe illness steroid steroid therapy therapy treated Treatment use of corticosteroid ventilator World Health Organization [DOI] 10.1016/j.resinv.2020.08.001 PMC 바로가기 [Article Type] Case Reports