A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells당뇨병 환경은 인간 신장 오르가노이드 및 환자 세포에서 SARS-CoV-2 감염에 대한 ACE2 발현 및 세포 감수성을 증가시킵니다Article Published on 2022-06-072022-09-11 Journal: Cell Metabolism [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 ACE2 expression aerobic aerobic glycolysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biopsy Cell cells cellular condition COVID-19 COVID-19 pathogenesis Critical develop diabete diabetes diabetes 2 Diabetic diabetic kidney diabetic patient diabetic patients dichloroacetate door energy metabolism enzyme exhibited Glycolysis hallmark human kidney human kidney organoids. increase individual inhibitor Intervention kidney Kidney disease kidney organoid kidney organoids metabolism mitochondrial Organoid organoids Patient prevented programming reduced resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe COVID-19 susceptibility Viral detection Viral load [DOI] 10.1016/j.cmet.2022.04.009 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Accessory Protein ORF8 Decreases Antibody-Dependent Cellular CytotoxicitySARS-CoV-2 액세서리 단백질 ORF8은 항체 의존성 세포 세포 독성을 감소시킵니다Article Published on 2022-06-072022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Accessory accessory protein accessory proteins ADCC addition antibody-dependent cellular cytotoxicity bind CD16 CD8+ T cell coronavirus decrease disease evade Fc-mediated effector function help host immune responses humoral responses identify immune evasion monocyte Monocytes mononuclear cell mutate nanomolar affinity Neutralizing antibodies NK cells ORF8 PBMC Peripheral blood Protein reduce reducing SARS-CoV-2 SARS-CoV-2-infected cell significantly spike susceptibility [DOI] 10.3390/v14061237 PMC 바로가기 [Article Type] Article
Smaller, Stronger, More Stable: Peptide Variants of a SARS-CoV-2 Neutralizing Miniprotein더 작고, 더 강하고, 더 안정적: SARS-CoV-2 중화 미니단백질의 펩타이드 변이체Article Published on 2022-06-042022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] amino acids antiviral activity approach breadth characterized complex de novo Degradation dissect full-length IMPROVE incorporation miniprotein Modification Mutation neutralization Neutralizing neutralizing capacity non-proteinogenic amino acids peptide peptide mimics peptides potency protein expression proteolytic RBD Receptor binding domain Recombinant protein reported resulting retained SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant Smaller Spike protein stability strength structure-based design susceptibility synthetic peptides the RBD the SARS-CoV-2 therapy variant virus virus variant VoC [DOI] 10.3390/ijms23116309 PMC 바로가기 [Article Type] Article
The Correlation Between Immune Invasion and SARS-COV-2 Entry Protein ADAM17 in Cancer Patients by Bioinformatic AnalysisArticle Published on 2022-06-032023-07-09 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] ADAM17 Cancer SARS-CoV-2 small molecule susceptibility Therapeutics [DOI] 10.3389/fimmu.2022.923516 PMC 바로가기
Beyond GWAS-Could Genetic Differentiation within the Allograft Rejection Pathway Shape Natural Immunity to COVID-19?GWAS를 넘어 동종이식 거부 경로 내 유전적 분화가 COVID-19에 대한 자연 면역을 형성할 수 있습니까?Article Published on 2022-06-032022-09-11 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Allograft allograft rejection Analysis annotation antiviral immunity applied Biomarker Biomarkers chromosome chromosome 6 chromosomes clinical presentation component components COVID-19 COVID-19 infection COVID-19 infections cumulative demonstrated differentiation disease Factor Genetic genetic variants genetics Genome-wide association study genomic GWAS Health help hospitalisation Host identify immune response immune responses immune system immunisation Infection investigated KEGG KEGG pathways Linear model majority mapped metabolic pathway metabolic pathways natural nucleotide outcome pathway Pathways Patient rejection resistance risk Risk assessment self Sequencing severe COVID-19 Severe COVID-19 Infection shape single nucleotide Single nucleotide polymorphism single variant SNP SNPs susceptibility Treatment variant whole genome Whole genome sequencing [DOI] 10.3390/ijms23116272 PMC 바로가기 [Article Type] Article
A country-specific model of COVID-19 vaccination coverage needed for herd immunity in adult only or population wide vaccination programme성인 전용 또는 전체 인구 백신 프로그램에서 집단 면역에 필요한 국가별 COVID-19 예방 접종 범위 모델Article Published on 2022-06-012022-09-11 Journal: Epidemics [Category] 변종, [키워드] addition Adults age Age structure booster calculate Care children Contact country Coverage COVID-19 vaccination demographics effective Effectiveness extension Herd herd immunity Immunity Impact IMPROVE Infection Measures Next generation matrix population level pre-vaccination proportion relative infectivity reproduction Reproduction number required Seroprevalence susceptibility symptomatic infection symptomatic infections vaccination Vaccine variant [DOI] 10.1016/j.epidem.2022.100581 PMC 바로가기 [Article Type] Article
Lysozyme Protects Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Inflammation in Human Corneal Epithelial Cells리소자임은 인간 각막 상피 세포의 중증 급성 호흡기 증후군 코로나바이러스 2 감염 및 염증으로부터 보호합니다Article Published on 2022-06-012022-09-11 Journal: Investigative ophthalmology & visual science [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Against analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 cell entry Cell toxicity characterized Corneal coronavirus coronavirus 2 Effect entry of SARS-CoV-2 enzyme epithelial cell epithelial cells expressed expression Human IL-6 Infection Inflammatory cytokine Inflammatory response luciferase lysozyme MCP-1 Pathogens pro-inflammatory molecule pro-inflammatory molecules proinflammatory molecule proinflammatory molecules PROTECT protective effect Protective effects pseudotyped respiratory robust RT-PCR SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection secretion Serine Spike protein Spike proteins stimulated suggested susceptibility tears TMPRSS2 TNF-α Toxicity transmembrane serine protease was measured was tested western blotting [DOI] 10.1167/iovs.63.6.16 PMC 바로가기 [Article Type] Article
Vaccination coverage rates and attitudes towards mandatory vaccinations among healthcare personnel in tertiary-care hospitals in Greece그리스 3차병원 의료진의 예방접종률과 필수 예방접종에 대한 태도Article Published on 2022-06-012023-06-01 Journal: Expert review of vaccines [Category] B형 간염, 두창, 백일해, 수두, 파상풍, 홍역, [키워드] Greece healthcare personnel Healthcare workers hospitals Immunity immunization susceptibility vaccination vaccination coverage [DOI] 10.1080/14760584.2022.2063118
Understanding the omicron variant (B.1.1.529) of SARS-CoV-2: Mutational impacts, concerns, and the possible solutionsReview article Published on 2022-06-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 변종, [키워드] addition antibody-based therapy B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Care change changes Consequences COVID-19 COVID-19 pandemic Delta Efficiency effort examined fertile globe Health immunocompromised individual impacts Infection International measure Mutation omicron Omicron variant Omicron variant (B.1.1.529) pre-existing immunity producing question raise raised SARS-CoV-2 severity susceptibility the SARS-CoV-2 the spike protein Transmissibility Travel understanding vaccination vaccination rate Vaccine variant variant of concern (VOC) variants virus VoC [DOI] 10.1016/j.amsu.2022.103737 [Article Type] Review article
COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trialsCOVID-19 및 비타민 D(Co-VIVID 연구): 무작위 대조 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-06-012022-09-11 Journal: Expert review of anti-infective therapy [Category] 임상, [키워드] 95% CI Area cholecalciferol ClinicalTrials Cochrane Library conducted Controlled trial COVID-19 COVID-19 patient COVID-19 patients COVID-19 susceptibility databases evaluate events Evidence expert group ICU admission indicated Intervention intervention group literature Meta-analysis Mortality outcome outcomes performed placebo group PROSPERO Randomized Randomized controlled trial Randomized controlled trials RCT RCTs Registered Relative risk reported risk RT-PCR SARS-CoV-2 severity significantly susceptibility systematic review Vitamin Vitamin D vitamin D levels with COVID-19 [DOI] 10.1080/14787210.2022.2035217 PMC 바로가기 [Article Type] Meta-Analysis