Development of a Broadly Accessible Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine PlatformVaccines and Antiviral Agents Published on 2018-03-142022-10-30 Journal: Journal of Virology [Category] Coronavirus, Fulltext, MERS, SARS, 조류인플루엔자, [키워드] addition Affect Aged antigen expression approach approaches biosafety BSL2 candidate vaccine condition coronavirus coronavirus development disease effective Efficacy Epidemics Heterologous heterologous challenge human populations in vivo Laboratory majority mice microbial model systems norovirus Norovirus outbreak outcome Particle Pathogens platform provide public health recombinant proteins replicon reported reservoir robust Safe Taking utility vaccination Vaccine vaccine platform vaccine strain VEE replicon Venezuelan equine encephalitis virus virus virus-like particles viruses VRP while wild-type [DOI] 10.1128/JVI.00027-18 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
Strong Selection at MHC in Mexicans since Admixture혼합 이후 멕시코의 MHC에서 강력한 선택Research Article Published on 2016-02-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence admixture African allele Analysis average coefficient Cohort credibility datasets dbGaP debate detect deviate difficulty European Europeans flexibility genetic difference Genome Genome-wide association study hallmark Haplotype humans inaccuracy Latino Local medical history Mexican Mexicans MHC performed populations Region reported Selection significantly statistical model Strong subject Taking the strongest [DOI] 10.1371/journal.pgen.1005847 PMC 바로가기 [Article Type] Research Article
Genome-Wide Association Mapping in Dogs Enables Identification of the Homeobox Gene, NKX2-8 , as a Genetic Component of Neural Tube Defects in Humans개의 게놈 전반에 걸친 연관 매핑을 통해 인간의 신경관 결함의 유전적 구성 요소인 호메오박스 유전자 NKX2-8 식별 가능Research Article Published on 2013-07-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition affected Analysis animal animal models Author birth defects Brain canine Care caused Central nervous system chromosome closure codon Combination comparable complex component condition contribute costly defect develop disease dog during pregnancy dysraphism embryonic ENCODE environmental factors etiology Evidence ExoN exons expected explain expressed failure found frameshift frameshift mutation general term Genes Genetic Genetic studies genetics Genome genome-wide association genomic region home environment Homeobox Human human population human populations humans identification identify in addition to interactions lead malformation mapped mapping mechanism Medical care molecular basis morbidity and mortality multifactorial Mutation Neural neural tube Neural tube defect Neural tube defects NKX2 NKX2-8 NTD NTDs occur pathology Patient performed predicted Pregnancy premature stop codon Protein rare variant Rare variants receive Regulatory regulatory gene reported resulting secondary to sequenced Sequencing significantly skin Soft tissue spina bifida spinal cord spinal dysraphism Structure Taking tissue tissues tube vertebral column Weimaraner [DOI] 10.1371/journal.pgen.1003646 PMC 바로가기 [Article Type] Research Article