Early indicators of microbial strain dysbiosis in the human gastrointestinal microbial community of certain healthy humans and hospitalized COVID-19 patients Research Published on 2022-04-212022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, 치료법, [키워드] Analysis Bacteroide Cluster colonization resistance Community COVID-19 detect Dysbiosis eight examined Fecal sample Gut healthy high-density hospitalized COVID-19 patient hospitalized patient Human individual individuals intrinsic KEGG majority metabolic pathway metabolism metagenomic microbes microbial microbial community Pathogens Patient patients hospitalized PKS selected unique Variation with COVID-19 [DOI] 10.1038/s41598-022-10472-w [Article Type] Research
Development and validation of cost-effective one-step multiplex RT-PCR assay for detecting the SARS-CoV-2 infection using SYBR Green melting curve analysisSYBR Green Melting Curve 분석을 이용한 SARS-CoV-2 감염 검출을 위한 비용 효율적인 1단계 다중 RT-PCR 분석법 개발 및 검증Article Published on 2022-04-202022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] combinations COVID-19 diagnosis detect development Diagnostic method E gene extracted RNA Host house Inc. Infection initial initial stage Internal control melting curve analysis multiplex Multiplex assay optimization PCR PCR reaction primer provided purification randomly selected sample ranged RdRP RdRp gene RdRp genes RNA extraction RT-PCR RT-PCR assay SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 virus sensitivity specificity subset SYBR Green TaqMan TaqMan probe the SARS-CoV-2 the SARS-CoV-2 virus Validity Variation Viral RNA were used β-actin [DOI] 10.1038/s41598-022-10413-7 PMC 바로가기 [Article Type] Article
Responses of aquatic organisms downstream from WWTPs to disinfectants and their by-products during the COVID-19 pandemic, Wuhan코로나19 팬데믹 기간 동안 WWTP에서 소독제 및 그 부산물에 대한 수중 생물의 반응, 우한Article Published on 2022-04-202022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, [키워드] accumulated Bacterial community Benthic macroinvertebrates benthos Chinese chlorinated chlorine Concentration correlated COVID-19 COVID-19 pandemic DBP density dichloromethane disinfectant Disinfection Disinfection residue Diversity downstream drinking water ecosystem Efficiency fluctuation fluctuations functional group highest impacted indirect effect investigated involved metabolism occurred organism outbreak Phytoplankton plankton ranged reduction Residual chlorine resource response river River ecosystem significantly surface runoff the SARS-CoV-2 Total Treatment trichloromethane Variation variations water Water treatment Wuhan zooplankton Zooplankton. [DOI] 10.1016/j.scitotenv.2021.151711 PMC 바로가기 [Article Type] Article
MALVIRUS: an integrated application for viral variant analysisMALVIRUS: 바이러스 변이체 분석을 위한 통합 애플리케이션Article Published on 2022-04-192022-09-11 Journal: BMC Bioinformatics [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis assist available data being Complete COVID-19 pandemic dataset demonstrated Effectiveness Efficiency Genotype genotyped genotyping GISAID globe Illumina Lineage Lineage classification NCBI produced provided recall required SARS-CoV-2 SARS-CoV-2 strain Sequence analysis sequencing data Spread supported Test the SARS-CoV-2 variant variants Variation variations viral strain viral strains viral variant virus [DOI] 10.1186/s12859-022-04668-0 PMC 바로가기 [Article Type] Article
Inter-individual variation in objective measure of reactogenicity following COVID-19 vaccination via smartwatches and fitness bands Research Published on 2022-04-192022-10-05 Journal: NPJ Digital Medicine [Category] 바이오마커, 유전자 메커니즘, 치료기술, 치료법, [키워드] Analysis baseline change changes confounding factors COVID-19 COVID-19 test COVID-19 vaccination detect detectable dose Evidence first dose greater helping identify immune response increase in individual individuals information initial Moderna mRNA vaccine participant peaked platform positive provided reactogenicity reported Research returned second dose significantly Standard deviation Symptoms tested trajectory vaccination Vaccine Vaccine development vaccine dose vaccine-induced immune response Variation Volunteer [DOI] 10.1038/s41746-022-00591-z [Article Type] Research
Variation in the COVID-19 infection-fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis백신 이전 시대의 연령별, 시기별, 지역별 코로나19 감염-치명률 변화: 체계적 분석Article Published on 2022-04-162022-09-11 Journal: Lancet (London, England) [Category] COVID19(2023년), SARS, 변종, [키워드] a metric accounted adjusted African age age distribution Analysis Asian baseline Bayesian Care caused Clinical practice comorbid condition comorbid conditions country covariate covariates COVID-19 COVID-19 disease COVID-19 mortality death decrease determinant determinants disease Diseases distribution effort elevated estimate Evolution excluded exclusion criteria Factor foundation Geography Greece group health system health-care health-care system help heterogeneity Hierarchical highest hotspot identify IFR implication in some include indicate individual infections Infectious diseases interquartile range Intervention introduced Japan likelihood Local location lowest measure median Melinda Gate Melinda Gates meta-regression metric Mortality mortality rate mortality risk Moss obesity observation occurred Oman outbreak parameter pathogen physical distancing measures Population population prevalence Portugal post-hoc analysis Potential predictor Prevalence progression provide Regression reported Research resulting risk risk stratification SARS-CoV-2 virus sensitivity Seroprevalence seroprevalence survey Seven severe cases severity of COVID-19 Spain systematic analysis the disease the median the SARS-CoV-2 virus Transmission treatment for COVID-19 understanding USA Vaccine variants Variation widespread with COVID-19 [DOI] 10.1016/S0140-6736(21)02867-1 PMC 바로가기 [Article Type] Article
Human SARS-CoV-2 has evolved to increase U content and reduce genome size인간 SARS-CoV-2는 U 함량을 증가시키고 게놈 크기를 줄이기 위해 진화했습니다Article Published on 2022-04-152022-09-11 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid caused collected conducted content contributed coronavirus current Delta Evolution Evolution of SARS-CoV-2 Genome Health help Human in-depth analysis less lineages mutability Mutation no significant difference nucleotide omicron Omicron variants reduce reducing Replication SARS-CoV-2 significant difference Transmission understanding variant Variation variations virulent virus virus sample virus samples [DOI] 10.1016/j.ijbiomac.2022.02.034 PMC 바로가기 [Article Type] Article
The determinants of COVID-19 morbidity and mortality across countries Research Published on 2022-04-072022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] activities acute respiratory syndrome aggravate Characteristics combating country COVID-19 deaths determinant explain Factor Factors female GDP Government healthcare help identify increase Infection Infectious disease male-to-female ratio mitigate morbidity morbidity and mortality Mortality outcomes pandemic reduce Satisfaction severity of COVID-19 significantly temperature Variation [DOI] 10.1038/s41598-022-09783-9 [Article Type] Research
Mutational scanning of spike RBD protein for enhanced ACE2 affinity emerging Southeast Asia in the late transmission phase후기 전송 단계에서 동남아시아 신흥 ACE2 친화력 향상을 위한 스파이크 RBD 단백질의 돌연변이 스캐닝Article Published on 2022-04-072022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] ACE2 ACE2 binding analyzed Asia binding changed Cluster conserved coronavirus COVID-19 COVID-19 pandemic Deleterious Diversity dominant effective Epitopes evaluate facilitate higher affinity hotspot Human Human Security in silico MD simulations measure mutated Mutation Neutralizing Outbreaks Protein Quality of life RBD mutation RBD protein RBD region Salt Bridge SARS-CoV-2 SARS-CoV-2 virus stability the disease the RBD the SARS-CoV-2 virus Transmission transmitted Treatment vaccination Variation virus [DOI] 10.1038/s41598-022-09999-9 PMC 바로가기 [Article Type] Article
SARS‐CoV‐2 variants and vulnerability at the global levelReview Published on 2022-04-052022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] acute respiratory syndrome Alter antibody center Control coronavirus COVID‐19 decrease defined Delta plus variant delta variant extreme Features Immunity immunological Impact induce Modification Mutation neutralization Numerous observation Omicron variant prevention SARS‐CoV‐2 SARS‐CoV‐2 susceptibility susceptible vaccination variant variants of concern variants of interest Variation viral variant virus VoC [DOI] 10.1002/jmv.27717 PMC 바로가기 [Article Type] Review