Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)Immunology Published on 2020-06-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Administered Antiviral antiviral action antiviral property Ascorbate ascorbic acid caused convalescent plasma coronavirus COVID-19 COVID-19 patient Critically ill death develop Efficacy Evidence flavonoids Health healthcare high-risk population immune system immunomodulatory property Immunonutrition imperative Intervention investigated overlapping pandemic pharmacological agent pharmacological treatment prevention Prophylaxis quercetin respiratory SARS-CoV-2 shown Stress synergistic the disease Treatment Vitamin Vitamin C [DOI] 10.3389/fimmu.2020.01451 PMC 바로가기 [Article Type] Immunology
Adding Colchicine to the Antiretroviral Medication – Lopinavir/Ritonavir (Kaletra) in Hospitalized Patients with Non-Severe Covid-19 Pneumonia: A Structured Summary of a Study Protocol for a Randomized Controlled TrialLetter Published on 2020-06-052022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 added Adding anti-inflammatory effect Antibiotics anticipated antioxidant antioxidants antiretroviral blinded both group CDC center change Clinical course Clinical improvement Colchicine component Consensus Controlled COVID-19 COVID-19 infection COVID-19 patients digoxin dissemination dosage double blind double-blind study element enrolled equation estimate Final GFR glomerular filtration rate group help Hospital stay hospitalized COVID-19 patients hypersensitivity hypoxic in both group infected with COVID-19 Inflammation inflammatory disorders Inpatient interleukin-8 intubation invasive Iran Kaletra kidney transplant recipients Lopinavir/ritonavir lung Lung CT MDA mechanism Minerals Nasopharyngeal swab National number objective outcome oxidative stress Oxygenation pandemic parallel group participant pathologic pathway Patient patients percentage Pneumonia positive Prospective protocol QTc randomised randomised controlled trial randomization Randomized Rate Ratio receive recruited recruitment reducing reduction Registered RT -PCR Sample size serum creatinine status Tehran time tomography Trace element treat treated Treatment two group two groups Vitamin website WHO guideline with COVID-19 [DOI] 10.1186/s13063-020-04455-3 PMC 바로가기 [Article Type] Letter
Virtual screening and repurposing of FDA approved drugs against COVID-19 main proteaseResearch article Published on 2020-06-012022-10-05 Journal: Life sciences [Category] SARS, 신약개발, 치료제, [키워드] 2019 New Coronavirus 2019-nCoV2019 New Coronavirus 3-C-like protease 3CLpro3-C-like protease acting addition Antiviral approved Comparisons Coronavirus disease 2019 CoV COVID COVID-19 COVID-19coronavirus disease 2019 CoVs dataset docking drug drugs EEnvelope envelope Epidemics FDA approved drug investigated knowledge material membrane protein MERS MERS CoVMiddle East Respiratory Syndrome Coronavirus Middle East respiratory syndrome Coronavirus Mmembrane protein MPro nicotinamide NNucleocapsid nucleocapsid open reading frames ORFopen reading frames Phylogenetic phylogenetics protease provided Research resolved ribavirin Safe SARS CoV SARSSevere Acute Respiratory Syndrome CoV sequence Severe Acute Respiratory Syndrome CoV Significance Spike protein Sspike protein systemically Treatment Virtual screening virus Vitamin vitamin B12 Wuhan, China [DOI] 10.1016/j.lfs.2020.117627 [Article Type] Research article
Vitamin D Deficiency and Air Pollution Exacerbate COVID-19 Through Suppression of Antiviral Peptide LL37비타민 D 결핍과 대기 오염은 항바이러스 펩티드 LL37의 억제를 통해 COVID-19를 악화시킵니다Public Health Published on 2020-05-282022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 치료제, [키워드] acquisition Action African American age Air pollution airway carbon nanoparticles Cathelicidin cathelicidin/LL37 citrullination of peptide cleaved co-morbid condition co-morbid conditions COVID-19 COVID19 cytokine cytokine signaling demonstrated effective exposure to expression generate Genes immune immune system Infection infections influence insufficiency interfere Lung disease microbe microbes modulate modulating modulation morbidity morbidity and mortality outcome Particle Pollution public health threat reduce reduced reducing respiratory Respiratory tract infections risk risk factor Risk factors Safe SARS-CoV-2 severity severity of COVID-19 shown Signaling skin pigmentation smoke stimulate suppression synthesis the disease tobacco smoke Transcription VDD Viral virus viruses Vitamin Vitamin D vitamin D deficiency weakened while [DOI] 10.3389/fpubh.2020.00232 PMC 바로가기 [Article Type] Public Health
A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology AnalysisPerspective Published on 2020-04-242022-10-30 Journal: Nutrients [Category] COVID-19, [키워드] acid acquisition acting activate applied approach biological processe Biology Combination conducted coronavirus coronavirus CoV CoV infection Curcumin Cytokine storm dietary supplements excessive inflammatory response Genome glycyrrhizic acid Health immune immune response in vitro in vivo experiment Inflammation Inflammatory response Inflammatory responses inhibit inhibiting innate immune response interferon KEGG Kyoto MAPK signaling modulating network analysis NF-κB novel Ontology pathway pathway enrichment Pathways Prevent promote provide regulate Research response responses signaling pathway System System biology T-cells target therapy Vitamin Vitamin C [DOI] 10.3390/nu12041193 PMC 바로가기 [Article Type] Perspective
Oral vitamin A supplementation of porcine epidemic diarrhea virus infected gilts enhances IgA and lactogenic immune protection of nursing pigletsResearch Article Published on 2019-11-292022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] Acetate antibody secreting cell boost Cell correlated Critical determine diarrhea ENhance epidemic diarrhea gestation Gut homing IgA IgA antibody immune protection immune system Immunity inoculated intestinal lactation lactogenic lymphocyte mucosal immune oral PEDV pleiotropic effect Pregnancy pregnant RNA serum survival rate virus Vitamin vitamin A [DOI] 10.1186/s13567-019-0719-y PMC 바로가기 [Article Type] Research Article
Modeling the transboundary risk of feed ingredients contaminated with porcine epidemic diarrhea virusResearch Article Published on 2016-03-122022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] antimicrobial Beijing carrier China chloride choline condition Control corn diarrhea effective Epidemic epidemic diarrhea evaluate events fatty ingredient inoculated lysine lysine hydrochloride medium methionine modeling organized PEDV plant Porcine representing Result risk risk factor San Francisco Shanghai Soybean meal subset temperature tested Transboundary Transport treated Treatment USA viability virus Vitamin Vitamin D [DOI] 10.1186/s12917-016-0674-z PMC 바로가기 [Article Type] Research Article
Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia글리신과 엽산은 선천적 철모구성 빈혈의 모델을 개선합니다.Research Article Published on 2016-01-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 5-Ala 5-aminolevulinic acid addition Anemia anemic autosomal recessive biosynthetic pathway Blood blood cell Blood Transfusion Cell congenital congenital sideroblastic anemia derivative determine downstream effective exogenous glycine exogenously family member folate glycine glycine cleavage system Hem25 heme heme biosynthetic pathway heme synthesis hemoglobin homolog humans identify inherited anemia inherited anemias iron iron chelation knowledge metabolite Mitochondria mitochondrial mitochondrial glycine importer mitochondrial glycine importers mitochondrial glycine transporter mitochondrial glycine transporters Model molecular Mutation Patient precursors Protein red blood cell red blood cells required restore hemoglobin level restore hemoglobin levels Safe sideroblastic anemia Sideroblastic anemias SLC25 SLC25A38 synthesis the disease Tolerability Treatment Vitamin while yeast yeast cell yeast cells Ymc1 zebrafish [DOI] 10.1371/journal.pgen.1005783 PMC 바로가기 [Article Type] Research Article