Immunohistochemistry for detection of avian infectious bronchitis virus strain M41 in the proventriculus and nervous system of experimentally infected chicken embryosResearch Published on 2009-02-052022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] addition Affect age Allantoic fluid Antigen Brain bronchitis Cell chorioallantoic collected detected Diagnosis diagnostic different disease Embryo embryonic embryos fixed found gastrointestinal tract generate IBV IBV infection IHC immunohistochemistry induce Infected Infection Infectious Bronchitis Virus inoculated kidney kidneys liver lung M41 membrane MOST Myocardial nasal epithelium nervous system Neuron oviduct Pathogenesis PI Respiratory system Result sensitivity spleen strain Strains tissue tissue tropism vasculature virulence virus virus isolation [DOI] 10.1186/1743-422X-6-15 PMC 바로가기 [Article Type] Research
A Novel Replication-Competent Vaccinia Vector MVTT Is Superior to MVA for Inducing High Levels of Neutralizing Antibody via Mucosal VaccinationResearch Article Published on 2009-01-132022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Antigen Chinese dissemination doses Efficacy experiments generate genomic location Head-to-head comparison implication Inducing inoculated intramuscular intranasal Level maintain mice mucosal neutralizing antibody novel offer Prevent protective immune response response S gene SARS-CoV SARS-CoV neutralizing antibody spike glycoprotein Superior Tian vaccination Vaccine vaccine candidate vaccinia variant vector Viral transmission Viral vector was used wild-type [DOI] 10.1371/journal.pone.0004180 PMC 바로가기 [Article Type] Research Article
The expression and antigenicity of a truncated spike-nucleocapsid fusion protein of severe acute respiratory syndrome-associated coronavirusResearch Article Published on 2008-11-282022-10-28 Journal: BMC Microbiology [Category] Coronavirus, [키워드] absence analyzed antibody Antigen antigenicity antiviral efficacy assays BALB/c mice cloned coronavirus cross-reactivity determined diagnostic effective drugs effective vaccine ELISA Escherichia coli evaluate expressed expression expression vector fluorescent fusion protein HCoV 229E human coronavirus human coronaviruses humoral IFA immunization immunized mice immunoblot induce inhibit injected injection intranasally Laboratory test management mice National neutralization nucleocapsid OC43 Protein Quantitative reactivity Result RT-PCR SARS patient SARS virus Sensitivity and specificity sera T cell proliferation T-cell analysis T-cell Response vaccine candidate Viral load virus replication was performed [DOI] 10.1186/1471-2180-8-207 PMC 바로가기 [Article Type] Research Article
Antigenic characterization of severe acute respiratory syndrome-coronavirus nucleocapsid protein expressed in insect cells: The effect of phosphorylation on immunoreactivity and specificityArticle Published on 2007-05-112022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Analysis Antigen antigenic antigenicity assay baculovirus coronavirus correlation cross-reactivity determine diagnostic E. coli expressed facilitate immunoreactivity insect cell insect cells involved mAb molecular MOST N protein nucleocapsid nucleocapsid protein pathology phosphorylated Phosphorylation produced Protein protein phosphatase 1 reduced Research SARS infection SARS-CoV SARS-CoV N SARS-CoV N protein serum Severe acute respiratory syndrome specificity treated were expressed [DOI] 10.1016/j.virusres.2007.03.019 PMC 바로가기 [Article Type] Article
S1 gene sequence analysis of a nephropathogenic strain of avian infectious bronchitis virus in EgyptResearch Published on 2006-09-202022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] alignment alimentary tract Amino acid Analysis antibody Antigen bronchitis changes in characterized contagious country criteria cross-protective disease Endemic gene sequence genotyped histopathological Histopathology homology IBV include Infected Infectious Bronchitis Virus inoculation isolate kidney mass Massachusett moderate Mortality oviduct performed protection raise related renal respiratory tract tissues Result RT-PCR sequence sequence homology Serologically serotype strain the disease the S1 protein tonsil tracheal tropism Vaccine virus [DOI] 10.1186/1743-422X-3-78 PMC 바로가기 [Article Type] Research
Preparation and characterization of a novel monoclonal antibody specific to severe acute respiratory syndrome-coronavirus nucleocapsid proteinArticle Published on 2006-08-302022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Antigen assays C-terminus Cell coronavirus cross-reactivity Diagnosis diagnostic early diagnosis epitope expressed FIVE found generate Host IgG immune Infection insect cell linear epitopes mAb modulation monoclonal antibody N protein N proteins N-terminus nucleocapsid nucleocapsid protein pathology phosphorylated preparation Protein reactivity related SARS-CoV SARS-CoV N selected severe Severe acute respiratory syndrome suggested viral pathogenesis virus replication [DOI] 10.1016/j.virusres.2006.07.004 PMC 바로가기 [Article Type] Article
Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape MutantsResearch Article Published on 2006-07-042022-10-29 Journal: PLoS Medicine [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome Administered affected against SARS-CoV Alter Amino acid anti-SARS-CoV antibody antibody antibody concentration Antigen antigens approach arising Bacteria binding blocked Blood breadth carried caused center China close contact close person-to-person contact Combination complementary Concentration Control convalescent SARS patient coronavirus Coverage CR3014 CR3022 died different disease disease severity dose Effect effective Epidemic Epidemics epitope escape experiment feasible ferret ferrets finding generate glycoprotein Guangdong Health healthy Hong Kong Human human cell human cells human macrophage Human monoclonal antibody humans immune Immune escape immunization immunize in vitro individual effects Infected infecting Infection infectious Infectious disease information interact Interaction International killing Laboratory less limit lung damage Lung pathology mAb mAbs measure monoclonal monoclonal antibody Mutation neutralization neutralized NO organism Patient pharyngeal Prevent prevented prevention producing Prophylaxis provided quarantine recognize recognizing reduce reduction repeated replicated required Research researcher residue responsible SARS epidemic SARS-CoV SARS-CoV infection screened shown sick Spread strain suppress synergistic synergistic fashion synergy tested the disease the receptor-binding domain Travel treat variant variants viral escape viral spread virus virus Virus neutralization virus strain virus-neutralizing viruses website Wikipedia World Health Organization [DOI] 10.1371/journal.pmed.0030237 PMC 바로가기 [Article Type] Research Article