Intravenous methylprednisolone pulse as a treatment for hospitalised severe COVID-19 patients: results from a randomised controlled clinical trial입원한 중증 COVID-19 환자를 위한 치료제로서의 정맥내 메틸프레드니솔론 펄스: 무작위 대조 임상 시험의 결과Randomized Controlled Trial Published on 2020-12-242022-08-13 Journal: The European Respiratory Journal [Category] 임상, [키워드] 1:1 95% CI administration Analysis attending physician Block randomisation Clinical improvement clinical trial conducted Controlled clinical trial Corticosteroid Corticosteroids COVID-19 COVID-19 patient COVID-19 patients death demonstrated eligible patient hazard ratio hospitalised hospitalised patient Immunosuppressive treatment Inflammation Inflammatory marker inflammatory markers initiation of treatment intention-to-treat Intravenous injection Iran ITT log-rank test Methylprednisolone methylprednisolone group mortality rate oxygen oxygen saturation Patient pulmonary involvement pulse randomisation randomised controlled Randomly receive reduce respiratory Respiratory system Result safety analysis severe adverse event severe adverse events severe COVID-19 severe COVID-19 patient significantly increased significantly lower single-blind standard care standard care group suggested survival survival time therapeutic therapeutic agent Treatment Two patient two patients was done were excluded [DOI] 10.1183/13993003.02808-2020 PMC 바로가기 [Article Type] Randomized Controlled Trial
Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS‐CoV‐2 in the respiratory tractReview Published on 2020-12-232023-06-14 Journal: Pharmacology Research & Perspectives [Category] MERS, [키워드] Adjunctive therapy clinical trial COVID‐19 Proteases SARS‐CoV‐2 [DOI] 10.1002/prp2.698 PMC 바로가기 [Article Type] Review
Current Status and Future Prospects of Perinatal Stem Cells주산기 줄기세포 현황 및 향후 전망Review Published on 2020-12-232022-09-10 Journal: Genes [Category] MERS, SARS, 임상, [키워드] Allogeneic amniotic fluid/membrane Birth Blood candidate carried Cell Cell therapy cell type cell types Characteristics chorion circulatory systems clinical settings clinical trial clinical trials contribute Cord blood COVID-19 COVID19 pneumonia current decidua described feature fetus Future gestation growth hematological immunological disorder independent individual intrinsic Mesenchymal stromal cells mother nanomedicine non-hematopoietic cell non-hematopoietic cells organ Other Pathologies Perinatal perinatal tissue perinatal tissues phenotypical Placenta Pneumonia primary source regenerative regenerative medicine status STEM stem cell stem cells stromal cell stromal cells therapeutic therapy these cell These cells tissue tissue engineering tissues treat trials umbilical cord tissue/blood unique [DOI] 10.3390/genes12010006 PMC 바로가기 [Article Type] Review
Obstacles and Considerations Related to Clinical Trial Research During the COVID-19 PandemicMedicine Published on 2020-12-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] affecting approvals arising article Cancer catastrophic caused clinical Clinical research clinical trial Clinical trial design clinical trials Community compassionate use Confusion control groups COVID-19 COVID-19 crisis COVID-19 pandemic Data analysis data integrity Diseases effective Efficiency effort endpoints ethical concern Ethics Factor faster feasibility flexible fraction Health help include information maintain media medications misinformation multicenter trials obstacle off-label pandemic press Prospective clinical trial raised randomization released releases remote monitoring Research SARS-CoV-2 Scientific community subject Treatment Trial urgency virus [DOI] 10.3389/fmed.2020.598038 PMC 바로가기 [Article Type] Medicine
A cost/benefit analysis of clinical trial designs for COVID-19 vaccine candidatesCOVID-19 백신 후보에 대한 임상 시험 설계의 비용/편익 분석Research Article Published on 2020-12-232022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 임상, [키워드] adaptive Analysis best calibrated candidate Candidates clinical trial Clinical trial design clinical trials Combination Course COVID-19 vaccine death determine effective epidemiological expected greater Infection pandemic pandemic spread parameters provide randomized clinical trial Trial trials unique [DOI] 10.1371/journal.pone.0244418 PMC 바로가기 [Article Type] Research Article
COVID-19: A Global Challenge with Old History, Epidemiology and Progress So FarCOVID-19: 오래된 역사, 역학 및 지금까지의 발전을 통한 글로벌 도전Review Published on 2020-12-232022-09-10 Journal: Molecules [Category] MERS, SARS, 치료제, [키워드] acute respiratory disease acute respiratory diseases acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approved bat bats caused challenge clinical trial clinical trials Combination contagious coronavirus COVID-19 COVID-19 disease COVID-19 pandemic death death rate diagnostic disease doubling effective vaccine Effective vaccines epidemiological evaluated globe history Human human-to-human transmission humans Inclusion Infection management manuscript Mask Masks mechanism mechanism of action MERS MERS-CoV Middle East Middle East respiratory syndrome mode mortalities Novel coronavirus novel coronaviruses Occurrence outbreak pandemic Pandemics pathogenic coronaviruses pathogenicity Patient Patient management problem Progress reservoir respiratory respiratory diseases respiratory tract infection responsible SARS-CoV-1 SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread syndrome therapeutic Therapeutics these viruses transmitted Treatment Vaccine Viral viral infection viral outbreak viruses Wuhan Wuhan, China zoonotic [DOI] 10.3390/molecules26010039 PMC 바로가기 [Article Type] Review
The Need for Antiviral Drugs for Pandemic Coronaviruses From a Global Health PerspectiveMedicine Published on 2020-12-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Administered Antiviral antiviral drugs antiviral therapy caused clinical study clinical trial conserved coronavirus Coronaviruses COVID-19 COVID-19 pandemic creating Dexamethasone disease stage drug Drug discovery drugs early treatment effective global health hospital hospitalized patients Infection influenza viruses Interaction investigated majority Mortality outbreak preparedness pandemic pharmacotherapy Prevent recovery Remdesivir respiratory respiratory viral infection respiratory virus SARS-CoV-2 solidarity Stage symptom duration target product profile the disease the United State Treatment viral dynamics Viral load Viral pneumonia Viral protein widespread [DOI] 10.3389/fmed.2020.596587 PMC 바로가기 [Article Type] Medicine
Infections and Immunotherapy in Lung Cancer: A Bad Relationship?Review Published on 2020-12-222022-10-29 Journal: International Journal of Molecular Sciences [Category] B형 간염, COVID-19, MERS, [키워드] administration affecting Analysis Antibiotic therapy anticancer Antiretroviral therapy Bacterial infections Cancer cancer patient Clinical practice clinical trial complex correlation COVID-19 described disease Evidence excluded HBV HCV Hepatitis HIV Immune checkpoint inhibitors immune system Immunotherapy impairing implication Infection Infectious disease lung cancer lung cancer patient lung cancer patients management microbiota Mortality Non-small cell lung cancer outcome Patient patient subgroup patients patients treated performed Prognosis prognostic Prospective trial reported retrospective risk of COVID-19 safety profile suggested therapy Thoracic toxicities Treatment trials viral infection viral infections virus with HIV [DOI] 10.3390/ijms22010042 PMC 바로가기 [Article Type] Review
Regulators, Pivotal Clinical Trials, and Drug Regulation in the Age of COVID-19I. How are the COVID-19 Vaccines Being Approved? An International Review Published on 2020-12-212022-10-30 Journal: International journal of health services : plannin [Category] Coronavirus, [키워드] approval clinical clinical trial COVID-19 Critical cultures drug drug regulators drugs European Medicines Agency food Food and Drug Administration Health Canada implication information Medicine pivotal trials Regulatory Treatment Trial Vaccine [DOI] 10.1177/0020731420979824 PMC 바로가기 [Article Type] I. How are the COVID-19 Vaccines Being Approved? An International Review
Improving clinical trial outcomes in amyotrophic lateral sclerosis Reviews Published on 2020-12-182022-10-05 Journal: Nature reviews. Neurology [Category] 바이오마커, 신약개발, 임상, [키워드] accelerate addition advance ALS biological processe biological processes Biomarker Care clinical trial Clinical trial design Critical diagnosed disease Disease progression effective effective therapy environmental factor Evolution facilitate genetic mutations Improving individual individuals initial lack outcome pathogenic pathophysiology Patient Precision Progress promote review Stratification target the disease therapeutic approaches Therapeutic benefit Therapies therapy translation Treatment [DOI] 10.1038/s41582-020-00434-z [Article Type] Reviews