A pocket guide on how to structure SARS-CoV-2 drugs and therapiesSARS-CoV-2 약물 및 치료법을 구성하는 방법에 대한 포켓 가이드Review Published on 2020-12-182022-09-11 Journal: Biochemical Society Transactions [Category] SARS, 신약개발, 치료제, [키워드] clinical trial clinical trials Community COVID-19 COVID19 defined disease Drug discovery FIVE homologue identify Informing Intervention MERS MERS-CoV Replication Research resolved SARS-CoV SARS-CoV-2 SARS-CoV-2 drug SARS-CoV-2 proteins SARS-CoV-2 virus Stage structural biology Structure the SARS-CoV-2 virus Therapeutics therapy Treatment vaccination Viral viral replication virus [DOI] 10.1042/BST20200396 PMC 바로가기 [Article Type] Review
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial Research Published on 2020-12-172022-10-05 Journal: Nature Medicine [Category] SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory syndrome Adenovirus Adults antibody production Antibody Response antigen-specific T cell AZD1222 caused CD4+ T cell CD8+ T cells cell-mediated immune cell-mediated immune response ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine characterized clinical trial contribute coronavirus COVID-19 cytokine secretion Cytotoxic T cell disease effective vaccine Efficacy Exploratory analysis expressing full-length SARS-CoV-2 global pandemic host cell humoral IgG1 IgG3 Immune profile immune response immunogenicity data infected with SARS-CoV-2 interferon-γ neutralizing antibody Patient phase 2/3 trial Phenotypes progression Protective protective role reduce reported Safe SARS-CoV-2 SARS-CoV-2 vaccine single dose Spike protein Strong suggested T cell T cell response the SARS-CoV-2 Trial tumor necrosis factor-α two-dose regimen vaccination Vaccine vaccine candidate [DOI] 10.1038/s41591-020-01194-5 [Article Type] Research
Effects of curcumin-piperine co-supplementation on clinical signs, duration, severity, and inflammatory factors in patients with COVID-19: a structured summary of a study protocol for a randomised controlled trialCOVID-19 환자의 임상 징후, 기간, 중증도 및 염증 요인에 대한 커큐민-피페린 공동 보충제의 효과: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-12-172022-09-10 Journal: Trials [Category] 임상, [키워드] 1:1 age analyses anticipated Anticoagulant anticoagulant drugs assigned Blinding calculated Capsule clinical Clinical signs Clinical symptoms clinical trial clinical trials Co-supplementation completion conducted control group coronavirus coronavirus disease COVID-19 Curcumin Curcumin-piperine Diagnosis dinner disease Disease duration dissemination double-blind drugs Effect Efficacy element Enrollment exclusion criteria female Gender hospital hospital ward Hospital wards ICU include independent Inflammatory factor inflammatory factors inflammatory mediator Inflammatory mediators Inpatient intensive care intensive care unit Intervention Iran less male maltodextrin matching placebo mediators Medical Sciences number objective outcome Outpatient packaged Parallel Arm participant Patient patients PCR test piperine Placebo placebo-controlled placebo-controlled clinical trial protocol provided randomised randomised controlled trial Randomized Randomly receive Registered registration date registry researcher Sample size sealed sensitivity sequence severity status Stratification Study protocol supplementary material title total sample size Trial Trial registration turmeric university Version Warfarin website [DOI] 10.1186/s13063-020-04924-9 PMC 바로가기 [Article Type] Letter
Hydroxychloroquine as a Chemoprophylactic Agent for COVID-19: A Clinico-Pharmacological ReviewPharmacology Published on 2020-12-172022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] affecting agent airway epithelial cells Analysis animal model Asymptomatic carrier candidate drug Chemoprophylaxis clinical trial Concentration coronavirus coronavirus disease 19 COVID-19 COVID-19 pandemic dissect dose Efficacy Endolysosomes Evidence Factor HCQ HCW healthcare high-risk population Hydroxychloroquine in vivo inhibit inhibitory effect observational study pharmacokinetic pharmacological Postexposure Prophylaxis presymptomatic transmission Prophylactic Prophylaxis PROTECT replicate responsible reveal review SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 TMPRSS2 Transmissibility Transport Vero Cell viral entry [DOI] 10.3389/fphar.2020.593099 PMC 바로가기 [Article Type] Pharmacology
Drug Repurposing for Prevention and Treatment of COVID-19: A Clinical LandscapeReview Article Published on 2020-12-162022-11-01 Journal: Discoveries [Category] COVID-19, [키워드] accelerate accumulate addition affected approval approved candidate caused clinical clinical trial clinically coronavirus COVID-19 COVID-19 patient COVID-19 vaccine distribution drug drug repositioning Effect effective expected FDA help Infection information lack landscape Mutation Novel coronavirus outbreak pandemic pandemic of COVID-19 phases Potential treatment prevention Remdesivir repurposing Research resource respond responsible SARS-CoV-2 suggested Therapeutics therapy treat Treatment USA Vaccine Vaccines viral infection virus [DOI] 10.15190/d.2020.18 PMC 바로가기 [Article Type] Review Article
Two-year outcomes of the treat-and-extend regimen using aflibercept for treating diabetic macular oedemaArticle Published on 2020-12-162022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] analysed baseline changes clinical trial comparable Diabetic Diseases dosing regimens Efficacy eye FIVE fixed flexible Health care injection Injections intravitreal injection Medical research multicentre oedema outcome Patient patients reduced regimen severity single-arm visual acuity visual impairment was performed [DOI] 10.1038/s41598-020-78954-3 PMC 바로가기 [Article Type] Article
The Large Action of Chlorpromazine: Translational and Transdisciplinary Considerations in the Face of COVID-19Pharmacology Published on 2020-12-162022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Action activity acute respiratory syndrome addition anti-SARS-CoV-2 activities Antipsychotics Antiviral antiviral activity antiviral medication antiviral properties Care caused Cell cell entry chlorpromazine clathrin Clathrin-mediated endocytosis clinical trial clinical trials coronavirus Coronavirus disease 2019 Course COVID-19 COVID-19 patient CPZ Critical defined described dosage drug early stage Efficacy evaluated event face good quality Health Human Infection information Interaction Largactil maintain mechanism of action medication Neuropsychiatric pandemic phenothiazine professional provided psychiatrist psychiatry psychotropic drug regimen Research protocol SARS-CoV-2 second wave Side effects Spread treat Treatment viral entry virus [DOI] 10.3389/fphar.2020.577678 PMC 바로가기 [Article Type] Pharmacology
Evidence and implications of pre‐existing humoral cross‐reactive immunity to SARS‐CoV‐2SARS-CoV-2에 대한 기존 체액 교차 반응성 면역의 증거 및 의미Original Research Published on 2020-12-152022-09-10 Journal: Immunity, Inflammation and Disease [Category] MERS, SARS, 진단, 치료법, [키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody Antigen approach approaches building clinical trial collected coronavirus coronavirus disease Coronavirus disease 2019 Critical Elecsy healthcare healthy humoral Immunity Immunoglobulin immunoglobulins implication investigated knowledge nucleocapsid pandemic reactive reactivity respiratory respond Result SARS‐CoV‐2 sera serological severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 subject tested Vaccine Volunteer [DOI] 10.1002/iid3.367 PMC 바로가기 [Article Type] Original Research
Importance of Pediatric Inclusion in COVID-19 Therapeutic TrialsCOVID-19 치료 시험에서 소아 포함의 중요성Article Published on 2020-12-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, [키워드] age children clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 Ethics excluded Importance include Inclusion Patient Pediatric patients pediatrics rationale SARS-CoV-2 therapeutic therapeutic trials Trial trials [DOI] 10.1093/cid/ciaa656 PMC 바로가기 [Article Type] Article
Equipoise, Trust, and the Need for Cardiologists to Randomly Assign Patients Into Anticoagulation Trials in the Time of COVID코로나 시대에 심장 전문의가 환자를 항응고 시험에 무작위로 배정해야 하는 균형, 신뢰, 필요성Article Published on 2020-12-152022-09-11 Journal: Circulation [Category] Fulltext, MERS, 임상, [키워드] Abstract cardiologist clinical trial clinical trial protocols Controlled trial COVID COVID-19 heparin Post-exposure prophylaxis Randomized controlled trial time Trust [DOI] 10.1161/CIRCULATIONAHA.120.052069 PMC 바로가기 [Article Type] Article