Chloroquine in fighting COVID-19: good, bad, or both?COVID-19와 싸우는 클로로퀸: 좋은 것, 나쁜 것 또는 둘 다?Article Published on 2020-12-012022-09-11 Journal: Autophagy [Category] MERS, SARS, 임상, 진단, [키워드] anti-malarial drug autophagy Chloroquine clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 develop drug elevated Evidence Hydroxychloroquine mortality rate pandemic progression SARS-CoV-2 [DOI] 10.1080/15548627.2020.1796014 PMC 바로가기 [Article Type] Article
Clinical stage molecule PT150 is a modulator of glucocorticoid and androgen receptors with antiviral activity against SARS-CoV-2임상 단계 분자 PT150은 SARS-CoV-2에 대한 항바이러스 활성이 있는 글루코코르티코이드 및 안드로겐 수용체의 조절제입니다.Article Published on 2020-12-012022-09-11 Journal: Cell cycle (Georgetown, Tex.) [Category] SARS, 치료제, [키워드] ACE2 activity androgen Androgen receptor Anti-SARS-CoV-2 Activity antidepressant Antiviral antiviral activities antiviral activity Cell cellular clinical clinical trial Concentration cortisol COVID-19 COVID-19 progression downregulation effective epithelial lining glucocorticoid Glucocorticoid antagonist Glucocorticoid receptor glucocorticoid receptor (GR immunomodulatory effect IND inhibitory member modulating modulation molecules Phase 1 Phase 2 phase 2 clinical trials platform predominant PT150 receptor safety profile SARS-CoV-2 suggested tested therapeutic TMPRSS2 TMPRSS2 expression variety virus [DOI] 10.1080/15384101.2020.1859752 PMC 바로가기 [Article Type] Article
Use of hydroxychloroquine and chloroquine in COVID-19: How good is the quality of randomized controlled trials?COVID-19에서 하이드록시클로로퀸과 클로로퀸의 사용: 무작위 대조 시험의 품질은 어느 정도입니까?Review Published on 2020-12-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 임상, [키워드] adjusted Adverse adverse events baseline Biase biases can not Care Chloroquine classification clinical trial clinical trials cohort of patients Comorbidities Comorbidity CONSORT coronavirus Coronavirus 2019 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic criteria Critical database deviation disease severity dismissal Effectiveness estimate evaluated Evidence extension Harm reporting HCQ Health Health care Hydroxychloroquine identify inclusion criteria Intervention lead many cases non-randomized non-randomized trial outcome patients with COVID-19 randomization Randomized randomized trial randomized trials recruited reported Reporting resources resulting risk risk of bia searched selective Standard Treatment Trial trials was used were used [DOI] 10.1016/j.ijid.2020.09.1470 PMC 바로가기 [Article Type] Review
Rapid Adaptation of a Surgical Research Unit to Conduct Clinical Trials During the COVID-19 PandemicCOVID-19 전염병 동안 임상 시험을 수행하기 위한 외과 연구 단위의 신속한 적응Article Published on 2020-12-012022-09-11 Journal: The Journal of surgical research [Category] 임상, [키워드] adaptation approach Azithromycin benefit clinical Clinical research Clinical studies clinical trial clinical trials Clinical trials unit coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Department division drug effective Efficacy endpoints Hydroxychloroquine impacted include mitigate morbidity morbidity and mortality observational studies observational study pandemic participant patients with COVID-19 randomized control trial Randomized control trials Rapid recent Regulatory Remdesivir Research Safe SARS-CoV-2 standstill Study participants surgery Surgical Research. Therapeutic treatment Trial unit [DOI] 10.1016/j.jss.2020.06.049 PMC 바로가기 [Article Type] Article
Known drugs and small molecules in the battle for COVID-19 treatmentReview article Published on 2020-12-012022-10-05 Journal: Genes & Diseases [Category] 치료법, 치료제, [키워드] Chloroquine clinical trial Combination components controlled trials coronavirus COVID-19 death drug drugs enzyme Famotidine FIVE hospital human cells Ivermectin knowledge lack Nicotine occurred other diseases outbreak pandemic Placebo Randomized Remdesivir replicate Replication SARS-CoV2 small molecule Transport treat Treatment virus while World Health Organization zinc ion [DOI] 10.1016/j.gendis.2020.06.007 [Article Type] Review article
Mining the past to treat the present, ever mindful of the future: Low-dose radiotherapy and COVID-19 pneumoniaEditorial Published on 2020-12-012023-07-12 Journal: Cancer [Category] SARS, [키워드] ARDS clinical trial COVID-19 Pneumonia Radiation [DOI] 10.1002/cncr.33201 PMC 바로가기 [Article Type] Editorial
Completion of clinical trials in light of COVID-19COVID-19에 비추어 임상 시험 완료Article Published on 2020-12-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] SARS, 임상, [키워드] clinical trial completion COVID-19 [DOI] 10.1016/S2213-2600(20)30460-4 PMC 바로가기 [Article Type] Article
A score combining early detection of cytokines accurately predicts COVID-19 severity and intensive care unit transfer사이토카인의 조기 발견을 결합한 점수는 COVID-19 심각도와 중환자실 이송을 정확하게 예측합니다Article Published on 2020-12-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] 95% CI AUC Care clinical trial clinical trials collected Combination contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity Critically ill critically ill patients cutoff value cytokine cytokine profile Cytokines diagnosed disease severity five group five groups form highest Hospital admission ICU IL-10 IL-6 IL-8 IMPROVE Inflammatory cytokines intensive care intensive care unit mechanical ventilation Non-severe case non-severe cases PaO2 PaO2/FiO2 ratio parameter Patient patient triage predict prediction Predictive Prognosis progression SARS-COV-2 infection sensitivity Serum level serum levels serum sample serum samples severity specificity the disease therapeutic strategy transfer [DOI] 10.1016/j.ijid.2020.10.003 PMC 바로가기 [Article Type] Article
Sex Differences in Reported Adverse Drug Reactions to COVID-19 Drugs in a Global Database of Individual Case Safety Reports개별 사례 안전성 보고서의 글로벌 데이터베이스에서 보고된 COVID-19 약물에 대한 보고된 약물 부작용의 성별 차이Article Published on 2020-12-012022-09-11 Journal: Drug safety [Category] 신약개발, 진단, 치료제, [키워드] (azithromycin abdominal pain acute respiratory syndrome acute respiratory syndrome coronavirus ADR ADRS Adverse Adverse drug reaction Algorithm Azithromycin Chloroquine clinical trial Combination coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19-specific treatment COVID-19-specific treatments database diarrhoea difference drug drug reaction drugs Effectiveness electrocardiogram evaluate event females fixed Frequency Health Organization Hepatitis Hydroxychloroquine identify indication indications individual International investigated Lopinavir Lopinavir/ritonavir male males nausea Non-COVID-19 Numerous Other pandemic pattern performed reaction Remdesivir remdesivir) renal report reported respiratory review Ritonavir Safety Sex Sex difference solidarity the disease therapeutic Treatment treatment of COVID-19 Trial vomiting World Health Organization Wuhan Wuhan, China [DOI] 10.1007/s40264-020-01000-8 PMC 바로가기 [Article Type] Article
Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposingReview article Published on 2020-12-012022-10-05 Journal: Pharmacology & therapeutics [Category] 신약개발, [키워드] Anti-cancer therapy antimalarial drug Artemisinin artemisinins artesunate Cancer class clinical trial daily dose death disease Drug repurposing greater income indicated majority middle occur oncology pandemic Pathways significantly targeting therapeutic Tolerability Treatment unique variety [DOI] 10.1016/j.pharmthera.2020.107706 [Article Type] Review article